Tramadol Induced Seizure: A Case Report

Year 2015, Volume: 40 Issue: 1, 174 - 177, 10.09.2015

Seyran Bozkurt Ataman Köse Cüneyt Ayrık Deniz Gökkıyas Hüseyin Narcı

https://doi.org/10.17826/cutf.51757

Cited By: 1

Abstract

Tramadol is widely consumed in the market, due to the increased use as analgesic and low potential of addiction. In cases of poisoning is rare, but serious complications can be seen as a seizure. It is reported that the smallest dose of tramadol associated seizure is 500 mg. In our case, the seizure was at a lower dose. In this study; we aimed to present case that was brought in emergency deparment with convulsions complaint after using 350 mg of tramadol.Tramadol should be questioned in patients who previously without a history of epilepsy and presenting to the emergency department with complaints of seizures

Keywords

Tramadol, seizures, toxicity

Tramadol Kullanımına Bağlı Nöbet: Olgu Sunumu

Abstract

Tramadolün bağımlılık potansiyelinin düşük olması ve analjezik olarak kullanımın artması nedeni ile piyasada yaygın olarak tüketilmektedir. Zehirlenme olgularında nadir, ancak ciddi komplikasyon olarak nöbet görülebilmektedir. Konvülziyon için bildirilen en düşük doz 500 mg olarak rapor edilmiştir. Bizim vakamızda ise daha düşük dozda nöbet görülmüştür. Bu çalışmamızda 350 mg tramadol alımını takiben konvülziyon yakınması ile acil servisimize getirilen olguyu sunmayı amaçladık. Daha önceden epilepsi öyküsü olmayıp nöbet geçirme yakınması ile acil servise başvuran hastalarda tramadol kullanımı sorgulanmalıdır

Keywords

Tramadol, nöbet, toksisite

References

• Shadnia S, Soltaninejad K, Heydari K, Sasanian G, Abdollahi M. Tramadol intoxication: a review of 114 cases. Hum Exp Toxicol. 2008;27:201–5
• Yıldırım GB, Kocaman B, Özyurt Y, Sezen ÖK, Gezer
• A, Arıkan Z. Yüksek doz tramadol:olgu sunumu. Kartal Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2002;1:56-7
• Mugunthhan N, Davoren P. Danger of hypoglycemia due to acute tramadol poisoning. Endocr Pract. 2012;18:151-2.
• Decker KD, Cordonnier J, Jacobs W, Coucke V, Schepens P, Jorens PG. Fatal intoxication due to tramado alone case report and review of the literature. Forensic Sci Int. 2008;175:79–82
• Spiller, HA, Gorman, SE, Villalobos, D, Benson, BE, Ruskosky, DR, Stancavage, MM, et al. Prospective multicenter evaluation of tramadol exposure. J Toxicol Clin Toxicol. 1997;35:361–4.
• Randall C, Crane J. Tramadol deaths in Northern Ireland: A review of cases from 1996 to 2012. J Forensic Leg Med. 2014;23:32-6.
• Talaie H, Panahandeh R, Fayaznouri MR, Asadi Z, Abdollahi M. Dose-independent occurrence of seizure with tramadol. J Med Toxicol. 2009;5:63-7.
• Shadnia S, Brent J, Fatemi KM, Hafezi P, Soltaninejad K. Recurrent seizures in tramadol intoxication: implications for therapy based on 100 patients. 2012;111:133–6.
• Gholami M, Saboory E, Milani SH. Proconvulsant effects of tramadol and morphine on pentylenetetrazol-induced seizures in adult rats using different routes of administration. Epilepsy Behav. 2014;36:90–6
• Sanaei-Zadeh H.Is prophylactic administration of the anticonvulsants necessary in tramadol-intoxicated patients after an initialseizure? Daru. 2013;21:60-1.