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Adipose-Derived Stem Cells and Application Areas

Year 2015, Volume: 40 Issue: 3, 399 - 408, 30.09.2015
https://doi.org/10.17826/cutf.44976

Abstract

The use of stem cells derived from adipose tissue as an autologous and self-replenishing source for a variety of differentiated cell phenotypes, provides a great deal of promise for reconstructive surgery. The secret of the human body, stem cells are reserved. Stem cells are undifferentiated cells found in the human body placed in any body tissue characteristics that differentiate and win ever known to cross the tissue instead of more than 200 diseases and thus improve and, rejuvenates the tissues. So far, the cord blood of newborn babies are used as a source of stem cells, bone marrow, and twenty years after tooth stem cells in human adipose tissue, scientists studied more than other sources of stem cells in adipose tissue and discovered that. Increase in number of in vitro studies on adult stem cells, depending on many variables is that the stem cells directly to the desired soybean optimization can be performed.. We will conclude by assessing potential avenues for developing this incredibly promising field. The aim of this paper is to review the existing literature on applications of harvest, purification, characterization and cryopreservation of adipose-derived stem cells (ASCs).

References

  • Gunes AM. Kök hücre plastisitesi ve tıptaki kullanım
  • alanları. Güncel Pediatri. 2005;3:36-42.
  • Kansu E. Kök hücre biyolojisi ve plastisitesinde
  • güncel kavramlar. Hacettepe Tıp Dergisi. 2005;36:19- 7.
  • TÜBA Kök Hücre Çalışma Grubu.Kök Hücre Araştırmalarında Güncel Kavramlar. Sayı 7, Ankara: Türkiye Bilimler Akademisi Raporları; 2004.
  • Rama P, Matuska S, Paganoni G, et al. Limbal stem- cell therapy and long-term corneal regeneration. N Engl J Med. 2010;36382:147-155.
  • Hayani A, Lampeter E, Viswanatha D, et al. First report of autologous cord blood transplantation in the treatment of a child with leukemia. Pediatrics. 2007;119:296-300. 6. Kadereit S. Stem Cells and Self-Renewal. http://www.isscr. org/public/SC_self-renewal.pdf.
  • Kök Hücre Biyolojisi ve Klinik Uygulamalar. 1,
  • Ankara: Türkiye Bilimler Akademisi, 2009.
  • Matur İ, Solmaz S. Current Approaches in Stem Cell Production. Archives
  • Medical Review Journal 2011;20:168-186.
  • Svendsen CN, Ebert AD (editors). Encyclopedia of Stem Cell Research. USA: SAGE Publications, 2008.
  • Wobus AM, Boheler KR (editors). Stem Cells. Handbook of Experimental Pharmacology, , Berlin and Heidelberg: Springer-Verlag, 2008:416.
  • NIH Stem Cells Information Home Page. Erişim: http://stemcells.nih.gov/index, 2013. Erişim tarihi: 02.08.2013.
  • Im GI. Adipose stem cells and skeletal repair. Histol Histopathol 2013;28:557-64.
  • Choi YS, Dusting GJ, Stubbs S, et al. Differentiation of human adipose-derived stem cells into beating cardiomyocytes. J Cell Mol Med. 2010;14:878-89.
  • Ning H, Lin G, Lue TF, et al. Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells. Differentiation. 2006;74:510-8
  • Wilson A, Butler PE, Seifalian AM. Adipose-derived stem cells for clinical applications: a review. Cell Prolif 2011;44:86-98.
  • Karoui S, Badri T, Benmously R, Ben Brahim E, et al. 2011;103:343-5. skin. Pathologica.
  • Zanetti AS, Sabliov C, Gimble JM, Hayes DJ. Human adipose-derived stem cells and three- dimensional scaffold constructs: A review of the biomaterials and models currently used for bone regeneration. J Biomed Mater Res B Appl Biomater 2013;101:187-99.
  • Phull MK, Eydmann T, Roxburgh J, et al. Novel macro-microporous gelatin scaffold fabricated by particulate leaching for soft tissue reconstruction with adipose-derived stem cells. J Mater Sci Mater Med. 2013;24:461-7.
  • Takashima Y, Era T, Nakao K, et al. Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell. 2007;129:1377-88.
  • Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322:583-6.
  • Huang H, Song TJ, Li X, et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci. 2009;106:12670-5.
  • Laudes M. Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes. J Mol Endocrinol. 2011;46:65-72.
  • Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature
  • Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454:1000-4.
  • Kajimura S, Seale P, Kubota K, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP- beta transcriptional complex. Nature. 2009;460:1154- 8.
  • Kapur SK, Wang X, Shang H, et al. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as 2012;4:025004. Biofabrication.
  • Bourin P, Bunnell BA, Casteilla L, et al. Stromal cells from the adipose tissuederived stromal vascular fraction and culture expanded adipose tissuederived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 2013;15:641-8.
  • Skalnikova H, Motlik J, Gadher SJ, Kovarova H. Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines. Proteomics. 2011;11:691-708.
  • Peinado JR, Pardo M, de la Rosa O, Malagon MM, Proteomic constituents, a necessary step for understanding adipose tissue complexity. Proteomics. 2012;12:607- 20. of adipose tissue
  • Türkiye Biyoetik Derneği Kök Hücre Araştırmaları ve Uygulamaları Kurulu Kök Hücre Araştırmalarının Etik ve Hukuk Boyutuna İlişkin Rapor Mart 2009.
  • Lopatina T, Kalinina N, Karagyaur M, et al. Adipose- derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS 10.1371/journal.pone.0017899. doi:
  • Rev Bras Cir Cardiovasc.
  • Zhang Y, Wang Y, Wang L, et al. Effects of Rehmannia glutinosa oligosaccharide on human adipose-derived mesenchymal stem cells in vitro. Life Sci 2012;91:1323-7.
  • Pak J. Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads. Pain Physician 2012;15:75e85.
  • Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol 2011;50:280-9.
  • Yang JJ, Yang X, Liu ZQ, Hu SY, Du ZY, Feng LL, et al. Transplantation of adipose tissue-derived stem cells overexpressing heme oxygenase-1 improves functions and remodeling of infarcted myocardium in rabbits. Tohoku J Exp Med. 2012;226:231-41.
  • Liu G, Cheng Y, Guo S, et al. Transplantation of adipose-derived stem cells for peripheral nevre repair. Int J Mol Med. 2011;28:565-72.
  • Razavi S, Ahmadi N, Kazemi M, Mardani M, Esfandiari E. Efficient transdifferentiation of human adipose-derived stem cells into Schwann-like cells: a promise for treatment of demyelinating diseases. Adv Biomed Res 2012;1:12.
  • Huang H, Liu N, Wang JH, et al. The effects of adipose-derived stem cells transplantation on the expression of TGF-β1 in rat brain after cerebral ischemia. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:872-5.
  • Wang JH, Liu N, Du HW, et al. Effects of adipose- derived stem cell transplantation on the angiogenesis and the expression of bFGF and VEGF in the brain post focal cerebral ischemia in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:958-61.
  • Kojima T, Kanemaru S, Hirano S, et al. Regeneration of radiation damaged salivary glands with adipose-derived stromal cells. Laryngoscope.
  • Lin G, Yang R, Banie L, et al. Effects of transplantation of adipose tissue-derived stem cells on prostate tumor. Prostate. 2010;70:1066-73.
  • Kucerova L, Matuskova M, Hlubinova K, Altanerova V, Altaner C. Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer. 2010;9:129.
  • Cho JA, Park H, Lim EH, et al. Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional myofibroblasts. Gynecol Oncol. 2011;123:379-86. of tumor-supporting
  • Josiah DT, Zhu D, Dreher F, Olson J, McFadden G, Caldas H. Adipose- derived stem cells as therapeutic delivery vehicles glioblastoma. Mol Ther. 2010;18:377-85.
  • oncolytic virus for
  • GuiZhu W, YanFeng S, Xiu Z, ZhongQing J. Adipose-derived stromal cell transplantation for treatment of stress urinary incontinence. Tissue and Cell. Tissue and Cell. 2011;43:246–53.
  • Sinna R, Delay E, Garson S, Delaporte T, Toussoun G. Breast fat grafting (lipomodelling) after extended latissimus dorsi flap breast reconstruction: a preliminary report of 200 consecutive cases. J Plast Reconstr Aesthet Surg 2010;63:1769–77.
  • Babovic S. Complete breast reconstruction with autologous fat graft – a case report. J Plast Reconstr Aesthet Surg. 2010;63:561–3.
  • Sterodimas A, Huanquipaco J, de Souza Filho S, Bornia FA, Pitanguy I . Autologous fat transplantation for the treatment of Parry-Romberg syndrome. J Plast Reconstr Aesthet Surg. 2009;62:424–6.
  • Pinsolle V, Chichery A, Grolleau JL, Chavoin JP. Autologous fat injection in Poland’s syndrome. J Plas. Reconstr Aesthet Surg. 2008;61:784–91.
  • Nelson L, Stewart K. Experience in the treatment of HIV-associated lipodystrophy. J Plast Reconstr Aesthet Surg. 2008;61:366–71.
  • Weber B, Emmert MY, Hoerstrup SP. Stem cells for heart valve 2012;142:13622. Swiss Med Wkly.
  • Robert WC, Michael FC. Recent advances in cancer stem cells. Current Opinion in Genetics & Development 2008;18:48–53.

Adipoz Kaynaklı Kök Hücreler ve Uygulama Alanları

Year 2015, Volume: 40 Issue: 3, 399 - 408, 30.09.2015
https://doi.org/10.17826/cutf.44976

Abstract

Kompleks bir canlı olan insan, olağanüstü bir koruma mekanizması geliştirerek zararlı olabilecek etkenlerden mümkün olduğunca kendini uzak tutar ve bunu başarabilmek için de bazı farklılaşmamış hücreleri kullanır. Yani her türlü doku kayıplarında yeniden fonksiyon gösterebilmesinin sırrı sahip olduğu kök hücrelerde saklıdır. Vücudumuzda farklılaşmamış bir hücre olarak bulunan kök hücreler herhangi bir organa yerleştirildiklerinde farklılaşıp o dokunun özelliklerini kazanarak şimdiye kadar bilinen oldukça fazla dokunun yerine geçebilmekte ve bu sayede hastalıkları iyileştirip, dokuları yenileyebilmektedir. Kök hücre kaynağı olarak kullanılan, kordon kanı, kemik iliği ve yirmi yaş dişinden sonra bilim adamları insan yağ dokusunda da kök hücre araştırdılar ve yağ dokusunda diğer kaynaklardan çok daha fazla kök hücre bulunduğunu keşfettiler. Bu hücreler üzerinde yapılan in vitro çalışmalar şunu gösteriyor ki bu hücrelerden birçok değişkene bağlı istenen soya yönelik doğrudan kök hücre optimizasyonu yapılabilmektedir. Bu derlemede de, adipoz kaynaklı kök hücrelerin saflaştırılması ve uygulamalarda kullanılması ile ilgili mevcut literatür gözden geçirilerek bilim dünyasına katı sağlaması amaçlanmıştır.

References

  • Gunes AM. Kök hücre plastisitesi ve tıptaki kullanım
  • alanları. Güncel Pediatri. 2005;3:36-42.
  • Kansu E. Kök hücre biyolojisi ve plastisitesinde
  • güncel kavramlar. Hacettepe Tıp Dergisi. 2005;36:19- 7.
  • TÜBA Kök Hücre Çalışma Grubu.Kök Hücre Araştırmalarında Güncel Kavramlar. Sayı 7, Ankara: Türkiye Bilimler Akademisi Raporları; 2004.
  • Rama P, Matuska S, Paganoni G, et al. Limbal stem- cell therapy and long-term corneal regeneration. N Engl J Med. 2010;36382:147-155.
  • Hayani A, Lampeter E, Viswanatha D, et al. First report of autologous cord blood transplantation in the treatment of a child with leukemia. Pediatrics. 2007;119:296-300. 6. Kadereit S. Stem Cells and Self-Renewal. http://www.isscr. org/public/SC_self-renewal.pdf.
  • Kök Hücre Biyolojisi ve Klinik Uygulamalar. 1,
  • Ankara: Türkiye Bilimler Akademisi, 2009.
  • Matur İ, Solmaz S. Current Approaches in Stem Cell Production. Archives
  • Medical Review Journal 2011;20:168-186.
  • Svendsen CN, Ebert AD (editors). Encyclopedia of Stem Cell Research. USA: SAGE Publications, 2008.
  • Wobus AM, Boheler KR (editors). Stem Cells. Handbook of Experimental Pharmacology, , Berlin and Heidelberg: Springer-Verlag, 2008:416.
  • NIH Stem Cells Information Home Page. Erişim: http://stemcells.nih.gov/index, 2013. Erişim tarihi: 02.08.2013.
  • Im GI. Adipose stem cells and skeletal repair. Histol Histopathol 2013;28:557-64.
  • Choi YS, Dusting GJ, Stubbs S, et al. Differentiation of human adipose-derived stem cells into beating cardiomyocytes. J Cell Mol Med. 2010;14:878-89.
  • Ning H, Lin G, Lue TF, et al. Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells. Differentiation. 2006;74:510-8
  • Wilson A, Butler PE, Seifalian AM. Adipose-derived stem cells for clinical applications: a review. Cell Prolif 2011;44:86-98.
  • Karoui S, Badri T, Benmously R, Ben Brahim E, et al. 2011;103:343-5. skin. Pathologica.
  • Zanetti AS, Sabliov C, Gimble JM, Hayes DJ. Human adipose-derived stem cells and three- dimensional scaffold constructs: A review of the biomaterials and models currently used for bone regeneration. J Biomed Mater Res B Appl Biomater 2013;101:187-99.
  • Phull MK, Eydmann T, Roxburgh J, et al. Novel macro-microporous gelatin scaffold fabricated by particulate leaching for soft tissue reconstruction with adipose-derived stem cells. J Mater Sci Mater Med. 2013;24:461-7.
  • Takashima Y, Era T, Nakao K, et al. Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell. 2007;129:1377-88.
  • Tang W, Zeve D, Suh JM, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322:583-6.
  • Huang H, Song TJ, Li X, et al. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci. 2009;106:12670-5.
  • Laudes M. Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes. J Mol Endocrinol. 2011;46:65-72.
  • Seale P, Bjork B, Yang W, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature
  • Tseng YH, Kokkotou E, Schulz TJ, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008;454:1000-4.
  • Kajimura S, Seale P, Kubota K, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP- beta transcriptional complex. Nature. 2009;460:1154- 8.
  • Kapur SK, Wang X, Shang H, et al. Human adipose stem cells maintain proliferative, synthetic and multipotential properties when suspension cultured as 2012;4:025004. Biofabrication.
  • Bourin P, Bunnell BA, Casteilla L, et al. Stromal cells from the adipose tissuederived stromal vascular fraction and culture expanded adipose tissuederived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 2013;15:641-8.
  • Skalnikova H, Motlik J, Gadher SJ, Kovarova H. Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines. Proteomics. 2011;11:691-708.
  • Peinado JR, Pardo M, de la Rosa O, Malagon MM, Proteomic constituents, a necessary step for understanding adipose tissue complexity. Proteomics. 2012;12:607- 20. of adipose tissue
  • Türkiye Biyoetik Derneği Kök Hücre Araştırmaları ve Uygulamaları Kurulu Kök Hücre Araştırmalarının Etik ve Hukuk Boyutuna İlişkin Rapor Mart 2009.
  • Lopatina T, Kalinina N, Karagyaur M, et al. Adipose- derived stem cells stimulate regeneration of peripheral nerves: BDNF secreted by these cells promotes nerve healing and axon growth de novo. PLoS 10.1371/journal.pone.0017899. doi:
  • Rev Bras Cir Cardiovasc.
  • Zhang Y, Wang Y, Wang L, et al. Effects of Rehmannia glutinosa oligosaccharide on human adipose-derived mesenchymal stem cells in vitro. Life Sci 2012;91:1323-7.
  • Pak J. Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads. Pain Physician 2012;15:75e85.
  • Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol 2011;50:280-9.
  • Yang JJ, Yang X, Liu ZQ, Hu SY, Du ZY, Feng LL, et al. Transplantation of adipose tissue-derived stem cells overexpressing heme oxygenase-1 improves functions and remodeling of infarcted myocardium in rabbits. Tohoku J Exp Med. 2012;226:231-41.
  • Liu G, Cheng Y, Guo S, et al. Transplantation of adipose-derived stem cells for peripheral nevre repair. Int J Mol Med. 2011;28:565-72.
  • Razavi S, Ahmadi N, Kazemi M, Mardani M, Esfandiari E. Efficient transdifferentiation of human adipose-derived stem cells into Schwann-like cells: a promise for treatment of demyelinating diseases. Adv Biomed Res 2012;1:12.
  • Huang H, Liu N, Wang JH, et al. The effects of adipose-derived stem cells transplantation on the expression of TGF-β1 in rat brain after cerebral ischemia. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011;27:872-5.
  • Wang JH, Liu N, Du HW, et al. Effects of adipose- derived stem cell transplantation on the angiogenesis and the expression of bFGF and VEGF in the brain post focal cerebral ischemia in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008;24:958-61.
  • Kojima T, Kanemaru S, Hirano S, et al. Regeneration of radiation damaged salivary glands with adipose-derived stromal cells. Laryngoscope.
  • Lin G, Yang R, Banie L, et al. Effects of transplantation of adipose tissue-derived stem cells on prostate tumor. Prostate. 2010;70:1066-73.
  • Kucerova L, Matuskova M, Hlubinova K, Altanerova V, Altaner C. Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer. 2010;9:129.
  • Cho JA, Park H, Lim EH, et al. Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional myofibroblasts. Gynecol Oncol. 2011;123:379-86. of tumor-supporting
  • Josiah DT, Zhu D, Dreher F, Olson J, McFadden G, Caldas H. Adipose- derived stem cells as therapeutic delivery vehicles glioblastoma. Mol Ther. 2010;18:377-85.
  • oncolytic virus for
  • GuiZhu W, YanFeng S, Xiu Z, ZhongQing J. Adipose-derived stromal cell transplantation for treatment of stress urinary incontinence. Tissue and Cell. Tissue and Cell. 2011;43:246–53.
  • Sinna R, Delay E, Garson S, Delaporte T, Toussoun G. Breast fat grafting (lipomodelling) after extended latissimus dorsi flap breast reconstruction: a preliminary report of 200 consecutive cases. J Plast Reconstr Aesthet Surg 2010;63:1769–77.
  • Babovic S. Complete breast reconstruction with autologous fat graft – a case report. J Plast Reconstr Aesthet Surg. 2010;63:561–3.
  • Sterodimas A, Huanquipaco J, de Souza Filho S, Bornia FA, Pitanguy I . Autologous fat transplantation for the treatment of Parry-Romberg syndrome. J Plast Reconstr Aesthet Surg. 2009;62:424–6.
  • Pinsolle V, Chichery A, Grolleau JL, Chavoin JP. Autologous fat injection in Poland’s syndrome. J Plas. Reconstr Aesthet Surg. 2008;61:784–91.
  • Nelson L, Stewart K. Experience in the treatment of HIV-associated lipodystrophy. J Plast Reconstr Aesthet Surg. 2008;61:366–71.
  • Weber B, Emmert MY, Hoerstrup SP. Stem cells for heart valve 2012;142:13622. Swiss Med Wkly.
  • Robert WC, Michael FC. Recent advances in cancer stem cells. Current Opinion in Genetics & Development 2008;18:48–53.
There are 57 citations in total.

Details

Primary Language English
Journal Section Review
Authors

Müjde Kıvanç This is me

Şamil Öztürk

Sevtap Gökalp This is me

İlhan Özdemir This is me

İbrahim Tuğlu This is me

Publication Date September 30, 2015
Published in Issue Year 2015 Volume: 40 Issue: 3

Cite

MLA Kıvanç, Müjde et al. “Adipose-Derived Stem Cells and Application Areas”. Cukurova Medical Journal, vol. 40, no. 3, 2015, pp. 399-08, doi:10.17826/cutf.44976.