Akut mesenterik iskeminin erken dönemlerinde ortalama platelet hacmi ve iskemi modifiye albümin düzeylerinin rolü: bir deneysel çalışma

Year 2019, Volume: 44 Issue: 1, 154 - 159, 31.03.2019

Güvenç Cantilav Tuna Bilecik Nurullah Bülbüller

https://doi.org/10.17826/cumj.453571

Abstract

Amaç: Bu çalışmanın amacı akut mezenterik sikeminin (AMİ) erken tanısında ortalama trombosit hacminin (MPV) ve iskemi modifiye albümin (IMA) dğzeylerinin rolünü belirlemekti.

Gereç ve Yöntem: Bu çalışmada, 18 Wistar Albino cinsi sıçan, her grupta 6 sıçan olacak şekilde 3 deney grubuna rasgele olarak ayrıldı; laparotomisiz şam grubu, laparotomi yapılan control grubu ve mezenterik iskemi grubu. Trombosit sayısı, MPV ve IMA, AMI grubunda 120. dk.lık superior mezenterik arter tıkanıklığının sonunda ve aynı zamanda diğer gruplarda çalışıldı.

Bulgular: AMI grubunda MPV ve IMA değerleri diğer 2 gruba göre anlamlı derecede yüksekti; trombosit sayısı anlamlı olarak düşüktü. Kontrol ve şam grupları arasında bu parametreler açısından istatistiksel olarak anlamlı bir fark yoktu.

Sonuç: AMI hızlı tanı konulmazsa oldukça mortal olabilen bir hastalıktır. Bu nedenle erken tanıda bu parametrelerin rolünü tanımlamak için daha fazla klinik çalışma gereklidir.

Keywords

Akut mezenter iskemi, Ortalama trombosit hacmi, İskemi modifiye albumin

The role of mean platelet volume and ischemia modified albumin levels in early periods of acute mesenteric ischemia: an experimental study

Abstract

The aim of this study was to determine the role of mean platelet volume (MPV) and ischemia modified albumin (IMA) in early diagnosis of acute mesenteric ischemia (AMI).

Materials and Methods: In this study, 18 Wistar Albino rats were randomly assigned to 3 experimental groups with 6 rats in each group as; sham group without laparotomy, control group with laparotomy and mesenteric ischemia-induced group. Platelet count, MPV and IMA were studied at the end of the 120th min of superior mesenteric artery obstruction in AMI group and at the same time in other groups.  

Results: In AMI group MPV and IMA values were significantly higher compared with other 2 groups, while platelet count was significantly lower . There was not any statistically significant difference between control and sham groups regarding these parameters. 

Conclusion: Further clinical studies are required to define the role of these parameters in early diagnosis of AMI since AMI is a highly mortal disease if not diagnosed promptly

Keywords

Acute mesenteric ischemia, mean platelet volume, ischemia modified albumin

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