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Mantar zehirlenmesinde akut karaciğer yetmezliğinin yordayıcısı olarak nötrofil-lenfosit oranının rolü

Year 2019, Volume: 44 Issue: 2, 566 - 571, 30.06.2019
https://doi.org/10.17826/cumj.455701

Abstract

Amaç: Çalışmamızda mantar zehirlenmeleri sonucunda karaciğer yetmezliği veya transplantasyon ihtiyacını önceden tahmin edilmesinde nötrofil/lenfosit oranı (NLO) ve demografik özelliklerin birlikte değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Hastalar cinsiyet, yaş, hastaneye başvuru ayı, acil servise başvuru semptomları, vital bulgular, laboratuvar değerleri, ilk semptomlarına göre zehirlenme ciddiyet skoru (ZCS), şikayetlerinin başlama zamanı açısından değerlendirildi. Hastalar karaciğer fonksiyon testlerinin bozulup bozulmamasına göre iki gruba ayrıldı.  ZCS’ye göre ve akut karaciğer yetmezliğinin olup olmamasına göre NLO değerlendirildi.

Bulgular: Yaşları 16-85 arasında olmak üzere 84 hasta çalışmaya dahil edildi.  NLO karaciğer fonksiyon testleri bozulmuş hastalarda (10.82±8.7), karaciğer fonksiyon testleri normal olanlara (5.66±4.71) göre istatistiksel olarak anlamlıydı. NLO’nun akut karaciğer yetmezliği gelişen hastalarda (17.77±9.44) şifa ile taburcu edilen hastalara göre (5.72±4.64) anlamlı derecede yüksek olduğu gözlendi. Cut-off değerinin 9.65 olduğu görüldü.

Sonuç: Mantar zehirlenmeleri sonucunda gelişebilecek karaciğer yetmezliği veya transplantasyon ihtiyacını erken tahmin edilmesinde NLO’nun  faydalı olabileceğini düşünmekteyiz.


References

  • Referans1: Zhou DC, Zhang H, Luo ZM, Zhu QX, Zhou CF. Prognostic value of hematological parameters in patients with paraquat poisoning. Sci Rep. 2016 Nov 8;6:36235
  • Referans2: Sun W, Zhang L, Luo M, Hu G, Mei Q, Liu D, Long G, Hu G. Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Head Neck. 2016;38:332-40
  • Referans3: Dundar ZD, Ergin M, Koylu R, Ozer R, Cander B, Gunaydin YK Neutrophil-lymphocyte ratio in patients with pesticide poisoning. J Emerg Med. 2014 ;47:286-93.

The role of neutrophil-lymphocyte ratio as a predictor of acute hepatic failure in mushroom poisoning

Year 2019, Volume: 44 Issue: 2, 566 - 571, 30.06.2019
https://doi.org/10.17826/cumj.455701

Abstract

Purpose: This study aimed to evaluate the value of neutrophil/lymphocyte ratio (NLR) together with the demographic characteristics in predicting liver insufficiency or transplantation need following mushroom poisoning. 

Materials and Methods: The patients were evaluated in terms of various parameters including gender, age, the month of admission, symptoms on emergency service admission, vital findings, laboratory findings, poisoning severity score (PSS) according to initial symptoms, and onset time of symptoms. The patients were divided into two groups according to whether the liver function tests were deteriorated or not. NLR was assessed according to PSS in patients with and without acute liver failure.

Results: A total of 84 patients, aged 16-85 years, were included in the study. Neutrophil/lymphocyte ratio was 10.82±8.7 in patients with impaired liver function tests and statistically significant compared to the patients with normal liver function tests (5.66±4.71). NLR was statistically significantly higher in patients who developed acute liver failure and in those with high poisoning severity score. The cut-off value was founded as 9.65.

Conclusion: NLR may be a useful predictor of liver failure or transplantation need, which develops as a result of mushroom poisoning.

References

  • Referans1: Zhou DC, Zhang H, Luo ZM, Zhu QX, Zhou CF. Prognostic value of hematological parameters in patients with paraquat poisoning. Sci Rep. 2016 Nov 8;6:36235
  • Referans2: Sun W, Zhang L, Luo M, Hu G, Mei Q, Liu D, Long G, Hu G. Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Head Neck. 2016;38:332-40
  • Referans3: Dundar ZD, Ergin M, Koylu R, Ozer R, Cander B, Gunaydin YK Neutrophil-lymphocyte ratio in patients with pesticide poisoning. J Emerg Med. 2014 ;47:286-93.
There are 3 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research
Authors

Bengü Gülhan Aydın 0000-0002-1324-6144

Gamze Küçükosman 0000-0001-5224-0258

Özcan Pişkin 0000-0003-3538-0317

Dilek Okyay 0000-0002-0520-7532

Bilgehan Açıkgöz 0000-0002-1405-5841

Hilal Ayoğlu This is me

Publication Date June 30, 2019
Acceptance Date November 21, 2018
Published in Issue Year 2019 Volume: 44 Issue: 2

Cite

MLA Aydın, Bengü Gülhan et al. “The Role of Neutrophil-Lymphocyte Ratio As a Predictor of Acute Hepatic Failure in Mushroom Poisoning”. Cukurova Medical Journal, vol. 44, no. 2, 2019, pp. 566-71, doi:10.17826/cumj.455701.