The relationship between neutrophil lymphocyte ratio and clinical outcomes after snakebite in pediatric patients

Year 2019, Volume: 44 Issue: 3, 1040 - 1045, 30.09.2019

Nagehan Aslan , Dinçer Yıldızdaş , Özden Özgür Horoz Faruk Ekinci Didar Arslan Sevcan Bilen , Hayri Levent Yılmaz

https://doi.org/10.17826/cumj.493805

Cited By: 2

Abstract

Purpose: Snake venom has serious cardiotoxic, neurotoxic, nephrotoxic effects. The neutrophil-to-lymphocyte ratio (NLR) is a new biomarker of inflammation and can be used as an indicator and prognositic marker of inflammation. In this study we aimed to analyze the association with clinical outcomes of pediatric patients with snakebite envenomation, and NLR.

Materials and Methods: A total of 61 pediatric patients with snakebite who admitted to a tertiary university hospital and a children’s hospital between July 2012 and July 2017 were included in the study. Demographic features, clinical findings and complications of snakebite, length of stay in hospital, NLR at admission (NLR1), and NLR at the twelfth hour (NLR2) and NLR at the discharge (NLR3) and mean platelet volume (MPV) were retrospectively reviewed and recorded.

Results: There was a positive correlation between NLR1 and the length of hospital stay. We found that as the level of NLR1 increased, the length of hospitalization was prolonged. NLR1 level increased as the disease stage progressed, but it was not statistically significant. Our study showed that when the severity of the illness increased, the length of hospital stay was significantly prolonged.

Conclusion: The study revealed a positive correlation with NLR and severity of the illness. We claim that NLR at admission can be a useful marker for predicting severe clinical course and prolonged hospital length of stay for pediatric patients with snake envenomation.

Çocuk hastalarda yılan sokması sonrası nötröfil lenfosit oranının klinik sonuçlarla ilişkisi

Abstract

Amaç: Yılan zehirinin ciddi kardiyotoksik, nörotoksik, nefrotoksik etkileri  mevcuttur. Nötrofil-lenfosit oranı inflamasyonun tanınmasında ve progresyonunda kullanılabilen yeni bir biyomarkerdır. Biz burada yılan sokması nedeni ile izlediğimiz hastaların klinik sonuçları ve nötrofil-lenfosit oranları (NLO) arasındaki ilişkiyi incelemek istedik.

Gereç ve Yönetem: Üçüncü basamak üniversite hastanesi ve bir çocuk hastanesinin çocuk acil ve çocuk yoğun bakım birimlerine, Temmuz 2012-Temmuz 2017 yılları arasında başvuran toplam 61 hastanın demografik özellikleri, klinik bulguları ve komplikasyonları, hastanede yatış süreleri retrospektif olarak tarandı. Başvurudaki (NLO1), 12.saatteki (NLO2), taburculuktaki (NLO3) nötrofil-lenfosit oranı ve mean platelet volüme (MPV) değerleri kaydedildi.

Bulgular: Hastanede yatış süresi ile NLO1 arasında pozitif korelasyon saptandı. NLO1 arttıkça hastanede yatışın uzadığını  ve yılan sokmasının evresinin arttığını saptadık. Yılan sokmasının evresi arttıkça hastanede yatış süresinin uzadığını görülmüştür.

Sonuç: Çalışmamız NLO ile hastalık ciddiyeti arasında pozitif korelasyon tespit etmiştir. Buradan yola çıkarak biz, başvuruda yüksek NLO değerleri olan yılan sokmalarında kötü klinik gidiş ve uzamış hastane yatışının öngörülebileceğini düşünmekteyiz. 

Keywords

pediatric, snake, envenomation bite

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