The evaluation of the early and intermediate age-related macular degeneration with optical coherence tomography angiography

Year 2020, Volume: 45 Issue: 1, 331 - 337, 31.03.2020

Emine Çiloğlu

https://doi.org/10.17826/cumj.659396

Abstract

Purpose: To investigate superficial and deep retinal vessels, foveal avascular zone in patients affected by age-related macular degeneration (AMD) to find whether any association between features on retinal vessel density and stage of AMD.
Materials and Methods: Ninety-four patients enrolled in the study. Patients were divided according to AMD stages. Grade 1, no AMD; grade 2, early AMD; grade 3, intermediate AMD; grade 4 geographic atrophy (GA); and Grade 5, choroidal neovascularization (CNVM). All patients underwent an ophthalmologic evaluation, including optical coherence tomography angiography (OCTA). The main outcome measures were superficial vessel density, deep vessel density, foveal avascular zone (FAZ).
Results: In grade 3 AMD eyes; the deep vessel density values were lower than grade 1 and grade 2 eyes. The fellow eyes of the patients with CNVM, the deep vessel density values were lower in grade 3 eyes than grade 1 and 2 eyes, the other parameters were not statistically different. The fellow eyes of the patients with grade 3, the vessel density, FAZ, AI did not show significant difference.
Conclusion: Changes in retinal capillary vessel density, which can be detected with OCTA, begin at the intermediate stage AMD. 

Keywords

Age related macular degeneration, superficial vessel density

Erken ve orta evre yaşa bağlı makula dejenerasyonunun optik koherens tomografi anjografi ile değerlendirilmesi

Abstract

Amaç: Yaşa bağlı makula dejenerasyonu (YBMD) olan hastalarda yüzeyel ve derin kapiller pleksus ve foveal avasküler zonu değerlendirmek, YBMD evresi ile kapiller damar yoğunluğu arasında ilişki olup olmadığını araştırmak.
Gereç ve Yöntem: Çalışmaya 94 hasta dahil edildi. Hastalar YBMD evresine göre sınıflandırıldı. Evre 1: YBMD yok, Evre 2: erken YBMD, Evre 3: orta evre YBMD, Evre 4: jeografik atrofi, Evre 5: koroidal neovaskülarizasyon (KNVM) evresi. Tüm hastalar optik koherens tomografi anjiografiyi de içeren tam oftalmolojik muayeneden geçirildi. Yüzeyel ve derin pleksuslarda vasküler yoğunluk, foveal avasküler zon ana ölçüm değerleri olarak belirlendi.
Bulgular: Evre 3 YBMD hastalarında derin pleksusta vasküler yoğunluk evre 1 ve 2 ye göre azalmış olarak tespit edildi. KNVM hastalarının diğer gözlerinde evre 3 YBMD tespit edilenlerde derin pleksusta kapiller yoğunluk evre 1 ve 2 ye göre daha düşük düzeylerde idi. Diğer parametrelerde farklılık yoktu. Evre 3 YBMD olan hastaların diğer gözlerinde kapiller yoğunluk ve foveal avasküler zon değerleri arasında farklılık saptanmadı.
Sonuç: OKTA ile tespit edilen retinal kapiller damarlarda değişiklikler intermediate YBMD aşamasında başlamaktadır.

Keywords

Yaşa bağlı makula dejenerasyonu

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