Antalya’da kolorektal kanser insidans ve sağkalım hızları, 2002–2016: topluma dayalı bir kayıt çalışması

Year 2020, Volume: 45 Issue: 4, 1346 - 1354, 27.12.2020

Oya Dirican Ünal Hülür

https://doi.org/10.17826/cumj.725299

Abstract

Amaç: Bu çalışma, Antalya İl Sağlık Müdürlüğü Kanser Kayıt Merkezi’nin 2002–2016 yılları arasını kapsayan verileri kullanarak ileri yaştaki kolorektal kanser tanılı hastaların insidans ve sağkalım hızlarını incelemeyi amaçlamıştır.
Gereç ve Yöntem: Antalya İl Sağlık Müdürlüğü bünyesinde aktif olarak sahadan veri toplayan topluma dayalı Kanser Kayıt Merkezi kayıtları kullanılarak, kolorektal kanser tanılı vakaların insidansları ile sağkalım hızları hesaplanmıştır.
Bulgular: Antalya’da 2002 – 2016 arasında genel insidans kadınlarda yüzbinde 19,5 ve erkeklerde yüzbinde 11,6 olarak bulunmuştur. Tanı konduğu sırada vakaların %75,0’i localize evreyi geçmiş durumda, %25,0’i uzak yayılım göstermektedir. Genel sağkalım süresi 6,0 ± 0,1 yıl olarak saptanmış ve 65 yaş öncesinde tanı almış olanlarda rölatif olarak daha uzun yaşam süresi olduğu görülmüştür. Rektum yerine kolonda yerleşmiş kanserlerin ile orta düzeyde diferansiye olanlar daha yüksek oranda 10-yıllık kümülatif sağkalım süresine sahiptir. Kolorektal kanser tanısını 65 yaşından önce almış olanların, daha sonra tanı almış olanlara göre 1,25 kez, cerrahi yolla tedavi edilenlerin, diğer yöntemlerle tedavi uygulananlara göre 7,53 kez daha iyi prognoza sahip oldukları görülmüştür.
Sonuç: Çalışma sonuçlarımıza göre, Antalya'da tanı anında kolorektal kanserin tespit edilen evresi ileri evredir ve bu nedenle sağkalım süresini uzatan cerrahi tedavi şansı daha az olmaktadır. Tanı sırasındaki tedavi türü prognozunu etkilediğinden erken tanı önem kazanmaktadır.

Keywords

kolorektal kanser, kolorektal kanser insidansı, kolorektal kanser sağkalım hızı

Supporting Institution

YOKTUR

Project Number

YOKTUR

Incidence of colorectal cancer and survival rates of older patients in Turkey, 2002 – 2016: a population - based registry study

Abstract

Purpose: This study aimed to investigate the incidence and survival rates of advanced colorectal cancer patients using data from 2002 to 2016 of the Antalya Provincial Health Directorate Cancer Registry Center.
Materials and Methods: The incidence and survival rates of cases diagnosed with colorectal cancer were calculated by using the community-based Cancer Registry Center records that actively collect data from the field within the Antalya Provincial Health Directorate.
Results: In Antalya, between 2002 and 2016, the overall incidence was found to be 19.5 per hundred thousand for women and 11.6 per hundred thousand for men. At the time of diagnosis, 75.0% of the cases have passed the localized phase, and 25.0% show distant spread. The overall survival time was 6.0 ± 0.1 years, and patients aged < 65 years old at diagnosis had a relatively longer survival time. The colon cancer and moderately differentiated groups had a higher 10-year cumulative survival. Patients aged < 65 years old at diagnosis had a better prognosis (1.25 times) than older patients, and patients treated surgically had a better prognosis (7.53 times) than those treated with other treatments.
Conclusion: According to our study results, the stage of colorectal cancer is more advanced at the time of diagnosis in Antalya, and therefore there is less chance of surgical treatment that extends the survival time more. Early diagnosis gains importance as the type of treatment during diagnosis affects its prognosis.

Keywords

colorectal cancer, colorectal cancer incidence, colorectal cancer survival rate

Project Number

YOKTUR

References

• Referans1 Bosman FT. WHO World Cancer Report 2014. Colorectal cancer, 1st edition. (Eds Stewart BW, Wild CP Lyon). International Agency for Research on Cancer. 2014; 392-403.
• Referans2 Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67(3):177-93.
• Referans3 Pilleron S, Sarfati D, Janssen-Heijnen M, Vignat J, Ferlay J, Bray F, et al. Global cancer incidence in older adults, 2012 and 2035: A population-based study. Int J Cancer. 2019;144(1):49-58.
• Referans4 Feletto E, Yu XQ, Lew JB, St John DJB, Jenkins MA, Macrae FA, et al. Trends in colon and rectal cancer incidence in Australia from 1982 to 2014: analysis of data on over 375,000 cases. Cancer Epidemiol Biomarkers Prev. 2019;28(1):83-90.
• Referans5 Wang MY, Lin GZ, Li Y, Dong H, Liao YH, Liu HZ, et al. Knowledge, attitudes, preventive practices and screening intention about colorectal cancer and the related factors among residents in Guangzhou, China. Asian Pac J Cancer Prev. 2017;18(12):3217-23.
• Referans6 Brændegaard WS, Baatrup G, Pfeiffer P, Qvortrup C, Academy of Geriatric Cancer Research (AgeCare). Trends in colorectal cancer in the elderly in Denmark, 1980-2012. Acta Oncol. 2016;55(1):29-39.
• Referans7 International Agency for Research on Cancer. Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018. 2018. (Internet) Available from: https://www.iarc.fr/featured-news/latest-global-cancer-data-cancer-burden-rises-to-18-1-million-new-cases-and-9-6-million-cancer-deaths-in-2018/ (accessed 22.07.2020).
• Referans8 Papamichael D, Audisio RA, Glimelius B, Gramont A, Glynne-Jones R, Haller D, et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann Oncol. 2015;26(3):463-76.
• Referans9 TC. Sağlık Bakanlığı Halk Sağlığı Kurumu Kanser Daire Başkanlığı. Türkiye Kanser Kontrol Programı. 2016. https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/yayinlar/raporlar/Ulusal_Kanser_Kontrol_Plani_2013_2018.pdf (accessed 16.5.2019).
• Referans10 Ansa BE, Coughlin SS, Mensah EA, Smith SA. Evaluation of colorectal cancer incidence trends in the United States (2000–2014). J Clin Med. 2018;7(2):22.
• Referans11 Parkin DM. The evolution of the population-based cancer registry. Nat Rev Cancer. 2006;6(8):603-12.
• Referans12 Altman DG, Gore SM, Gardner MJ, Pocock SJ. Statistical guidelines for contributors to medical journals. Br Med J. (Clin Res Ed)1983;7:1489-93.
• Referans13 Rim SH, Seeff L, Ahmed F, King JB, Coughlin SS. Colorectal cancer incidence in the United States, 1999-2004: an updated analysis of data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program. Cancer. 2009;115(9):1967-76.
• Referans14 Awad H, Abu-Shanab A, Hammad N, Atallah A, Abdulattif M. Demographic features of patients with colorectal carcinoma based on 14 years of experience at Jordan University Hospital. Ann Saudi Med. 2018;38(6):427-32.
• Referans15 Joachim C, Véronique-Baudin J, Razanakaivo M, Macni J, Dorival MJ, Smith-Ravin J, et al. Trends in colorectal cancer in the Caribbean: A population-based study in Martinique, 1982-2011. Rev Epidemiol Sante Publique. 2017;65(3):181-8.
• Referans16 Douaiher J, Ravipati A, Grams B, Chowdhury S, Alatise O, Are C. Colorectal cancer-global burden, trends, and geographical variations. J Surg Oncol. 2017;115(5):619-30.
• Referans17 Poornakala S, Prema NS. A study of morphological prognostic factors in colorectal cancer and survival analysis. Indian J Pathol Microbiol. 2019;62(1):36-42. . Referans18 Cook E, Gershman S, Knowlton R. Cancers among the oldest old in Massachusetts from 2004-2014. J Registry Manag. 2018;45(1):21-7.
• Referans19 Samawi HH, Yin Y, Speers CH, Cheung WY. Sex disparities in outcomes of early stage colorectal cancer: a population-based study. Clin Colorectal Cancer 2018;17(4):e7117
• Referans20 Türkoğlu A, Çetinkaya Z, Girgin M, Ayten R, Kanat BH, Binnetoğlu K, et al. Kolorektal kanserlerde prognostic faktörler. Dicle Tıp Dergisi. 2014;41(4):724-31.
• Referans21 Eser S, Chang J, Charalambous H, Silverman B, Demetriou A, Yakut C, et al. Incidence patterns of colorectal cancers in four countries of the Middle East Cancer Consortium (Cyprus, Jordan, Israel, and İzmir, Turkey) compared with those in the United States Surveillance, Epidemiology, and End Results Program. Turk J Gastroenterol. 2018;29(1):36-44.
• Referans22 Joachim C, Godaert L, Dramé M, Véronique-Baudin J, Macni J, Smith-Ravin J, et al. Overall survival in elderly patients with colorectal cancer: a population-based study in the Caribbean. Cancer Epidemiol. 2017;48:85-91.
• Referans23 Yamano T, Yamauchi S, Kimura K, Babaya A, Hamanaka M, Kobayashi M, et al. Japanese Study Group for Postoperative Follow-up of Colorectal Cancer. Influence of age and comorbidity on prognosis and application of adjuvant chemotherapy in elderly Japanese patients with colorectal cancer: A retrospective multicentre study. Eur J Cancer. 2017;81:90-101.