İkinci trimester nukal fold kalınlığının maternal karakteristikleri ve doğum ağırlığı ile ilişkisi

Year 2020, Volume: 45 Issue: 4, 1444 - 1448, 27.12.2020

Mehmet Murat Işıkalan Haççe Yeniçeri Ali Acar

Abstract

Amaç: Bu çalışmanın amacı ikinci trimesterdaki sağlıklı gebelerde maternal karekteristiklerin nukal fold kalınlığına etkisini ve nukal fold kalınlığı ile doğum ağırlığı arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem: Bu prospektif longitudinal çalışmaya perinatoloji kliniğimize Temmuz - Eylül 2019 tarihleri arasında ikinci düzey ultrason taraması için başvuran 18-22 haftalık sağlıklı gebeler dahil edildi. Maternal karekteristikleri kaydedildikten sonra tüm gebelere anomali taraması yapıldı. Nukal fold kalınlığı ölçüldü. Hastalar doğuma kadar takip edildi.
Bulgular: Toplam 115 gebe değerlendirildi. Gebelerin yaş ortalaması 29.1±4.0 idi. Nukal fold kalınlığı ortalaması 4.1±0.7 olarak belirlendi. Çoklu regresyon analizinde beden kitle indeksi, maternal yaş, fetal prezentasyon, fetal cinsiyet, parite ve plasenta lokalizasyonlarının nukal fold kalınlığı üzerine prediktif etkisi saptanmadı. Gebelik haftasıyla nukal fold kalınlığı arasında pozitif korelasyon saptandı. Ortalama doğum ağırlığı 3057±664 idi. Nukal fold kalınlığı ile doğum ağırlığı arasında anlamlı bir korelasyon saptanmadı.
Sonuç: Kromozom anomalisi olmayan fetüslerde nukal fold kalınlığı maternal yaş, beden kitle indeksi, fetal cinsiyet, plasenta lokalizasyonu, fetal prezentasyon ve pariteden etkilenmemektedir. Nukal fold kalınlığı gebelik haftasıyla orantılı olarak artmaktadır. Nukal fold kalınlığı ile doğum ağırlığı arasında bir ilişki yoktur.

Keywords

nukal fold, doğum kilosu, ikinci trimester, nukal kalınlık

Relation of nuchal fold thickness with maternal characteristics and birth weight

Abstract

Purpose: The aim of this study was to investigate the effect of maternal characteristics on nuchal fold thickness and the relationship between nuchal fold thickness and birth weight in healthy pregnant women in the second trimester.
Materials and Methods: This prospective longitudinal study included healthy pregnant women at 18-22 weeks of gestation who applied to our perinatology clinic for a second level ultrasound scan between July - September 2019. After recording the maternal characteristics, anomaly screening was performed to all pregnant women. The nuchal fold thickness was measured. The patients were followed until delivery.
Results: A total of 115 pregnant women were evaluated. The average age of pregnant women was 29.1 ± 4.0. The average nuchal fold thickness was determined as 4.1 ± 0.7. The predictive effect of body mass index, maternal age, fetal presentation, fetal gender, parity and placental location on nuchal fold thickness was not revealed in the multiple regression analysis. A positive correlation was found between gestational age and nuchal fold thickness. The average birth weight was 3057 ± 664. There was no significant correlation between nuchal fold thickness and birth weight.
Conclusion: In fetuses without chromosomal anomaly, nuchal fold thickness is not affected by maternal age, body mass index, fetal gender, placental location, fetal presentation and parity. The nuchal fold thickness increases in proportion to the gestational age. No relation was found between nuchal fold thickness and birth weight

Keywords

Birth weight, nuchal fold, nuchal translucency

References

• 1. Hobbins JC, Lezotte DC, Persutte WH, DeVore GR, Benacerraf BR, Nyberg DA, et al. An 8‐center study to evaluate the utility of midterm genetic sonograms among high‐risk pregnancies. Journal of ultrasound in medicine. 2003;22(1):33-8.
• 2. Benacerraf BR, Laboda LA, Frigoletto FD. Thickened nuchal fold in fetuses not at risk for aneuploidy. Radiology. 1992;184(1):239-42.
• 3. Hackmon R, Librach C, Burwick R, Rodrigues N, Farine D, Berger H. Do Early Fetal Measurements and Nuchal Translucency Correlate With Term Birth Weight? Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC. 2017;39(9):750-6.
• 4. Gluckman P, Liggins G. Regulation of fetal growth. Fetal physiology and medicine: Elsevier; 1984. p. 511-57.
• 5. Kalem Z, Ellibeş Kaya A, Bakırarar B, Namlı Kalem M. Fetal nuchal translucency: is there an association with birthweight and neonatal wellbeing? Turkish journal of obstetrics and gynecology. 2019;16(1):35-40.
• 6. Ben-Ami M, Perlitz Y, Mukary M, Peleg D. Nuchal fold thickness at 14-16 weeks' gestation as measured by transvaginal sonography. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2002;19(1):60-1.
• 7. Lee PR, Won HS, Chung JY, Shin HJ, Kim A. The variables affecting nuchal skin-fold thickness in mid-trimester. Prenatal diagnosis. 2003;23(1):60-4.
• 8. Cho JY, Kim KW, Lee YH, Toi A. Measurement of nuchal skin fold thickness in the second trimester: influence of imaging angle and fetal presentation. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2005;25(3):253-7.
• 9. Singh C, Biswas A. Impact of gestational age on nuchal fold thickness in the second trimester. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2014;33(4):687-90.
• 10. Kazemi K, Adibi A, Hovsepian S. Reference values of nuchal fold thickness in an Iranian population sample. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2018;23:94.
• 11. Boucoiran I, Djemli A, Taillefer C, Rypens F, Delvin E, Audibert F. First-trimester prediction of birth weight. American journal of perinatology. 2013;30(08):665-72.
• 12. Weissmann-Brenner A, Weisz B, Lerner-Geva L, Gindes L, Achiron R. Increased nuchal translucency is associated with large for gestational age neonates in singleton pregnancies. Journal of perinatal medicine. 2011;39(3):305-9.
• 13. Pihl K, Sørensen TL, Nørgaard-Pedersen B, Larsen SO, Nguyen TH, Krebs L, et al. First-trimester combined screening for Down syndrome: prediction of low birth weight, small for gestational age and pre-term delivery in a cohort of non-selected women. Prenatal Diagnosis. 2008;28(3):247-53.
• 14. Kokanali D, Coskun B, Kokanali MK, Tasci Y. ASSOCIATION BETWEEN FIRST-TRIMESTER ANEUPLOIDY MARKERS AND BIRTH WEIGHT. JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE. 2017;8:125-8.
• 15. Cho JY, Kim K, Lee Y, Toi A. Measurement of nuchal skin fold thickness in the second trimester: influence of imaging angle and fetal presentation. Ultrasound in Obstetrics and Gynecology: The Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2005;25(3):253-7.
• 16. Lee PR, Won HS, Chung JY, Shin HJ, Kim A. The variables affecting nuchal skin-fold thickness in mid-trimester. Prenatal Diagnosis. 2003;23(1):60-4.
• 17. Aagaard‐Tillery KM, Flint Porter T, Malone FD, Nyberg DA, Collins J, Comstock CH, et al. Influence of maternal BMI on genetic sonography in the FaSTER trial. Prenatal Diagnosis: Published in Affiliation With the International Society for Prenatal Diagnosis. 2010;30(1):14-22.