Endometriozis tanısı almış infertil hastalarda D vitamin düzeyinin değerlendirilmesi

Year 2020, Volume: 45 Issue: 4, 1672 - 1678, 27.12.2020

Berin Bayat Bekir Kahveci Ghanim Khatib İbrahim Ürünsak Yılmaz Atay

Abstract

Amaç: Bu çalışmanın amacı endometriozisi olan infertil hastalarda, endometirozis ve D vitamin düzeyi arasındaki ilişkiyi değerlendirmektir.
Gereç ve Yöntem: Çalışma grubunu, endometriozisi olan infertil hastalar, kontrol grubunu ise endometriozis dışı infertilite nedeni olan hastalar oluşturmaktadır. Çalışma grubuna sadece histopatolojik endometriozis tanısı bulunan hastalar dikkate alınmıştır. Hastaların yaşı, vücut kitle indeksi, infertilite süresi, ilk adet yaşı, sigara içme geçmişi, infertilite faktörü ve gebelik öyküsü ve anti-müllerian hormon düzeyleri gibi sosyodemografik ve klinik özellikleri ile laboratuvar değerleri ünitemizin kayıtlarından elde edildi.
Bulgular: Çalışmaya toplam 100 hasta dahil edildi. Çalışma ve kontrol gruplarında D vitamini düzeyleri karşılaştırıldığında, sırasıyla; 12,0 ± 8,6 ng/mL karşılık 14,7 ± 10,6 ng/mL ve AMH düzeyleri karşılaştırıldığında, sırasıyla; 2,0 ± 1,8 ng/mL karşılık 2,6 ± 2,3 ng/mL olarak tespit edildi. Grupların alt grup analizlerinde, sadece yaş dilimine göre 15-25 yaş arası olan hastalarda D vitamini seviyeleri arasındaki fark anlamlı bulunmuştur (5,8 ± 2,4 ng/mL karşılık 15,0 ± 8,5 ng/mL;.
Sonuç: D vitamini eksikliği olan endometriozisli genç kadınlarda D vitamini takviyesi faydalı olabilir.

Keywords

D vitamini, infertilite, endometriozis

Supporting Institution

yok

Project Number

yok

Evaluation of vitamin D levels in infertile patients diagnosed with endometriosis

Abstract

Purpose: The aim of this study was to evaluate the relationship between endometriosis and vitamin D level in infertility patients with endometriosis.
Materials and Methods: The study group consisted of infertile patients with endometriosis, while the control group consisted of infertile patients with causes other than endometriosis. Only patients diagnosed with histopathological endometriosis were considered in the study group. The sociodemographic, clinical features and laboratory values of the patients such as age, body mass index, duration of infertility, first menstrual age, smoking history, infertility factor, gestational history and anti-mullerian hormone levels were obtained from unit records.
Results: Totally 100 patients were included in the study. When vitamin D levels were compared in the study and control groups, respectively; 12.0 ± 8.6 ng / mL versus 14.7 ± 10.6 ng / mL, and AMH levels were compared, respectively; It was determined as 2.0 ± 1.8 ng / mL versus 2.6 ± 2.3 ng / mL. In the sub-analysis of the groups, only the difference in vitamin D levels of patients aged 15-25 (5.8 ± 2.4 ng / mL versus 15.0 ± 8.5 ng / mL) was significantly different.
Conclusion: Using vitamin D supplements in young women with endometriosis who have vitamin D deficiency could be beneficial.

Keywords

vitamin D, endometriosis

Project Number

yok

References

• 1. Albayrak E, Günay O. State and trait anxiety levels of childless women in Kayseri, Turkey. Eur J Contracept Reprod Health Care. 2007;12(4):385-90.
• 2. Vayena E, Rowe P, Griffin P. Current practices and controversies in assisted reprudiction: report of a meeting on medical, ethical and social aspets of assisted reprodiction held at WHO headquarters In; 2002 17-21 September 2001; Geneva, Switzerland; 2002.
• 3. Enstitüsü HÜNE, Sağlığı SBAÇ, Müdürlüğü APG. Başbakanlık Devlet Planlama Teşkilatı Müsteşarlığı ve TÜBİTAK. Türkiye Nüfus ve Sağlık Araştırması. 2008:149-69.
• 4. American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee. Female age-related fertility decline. Committee Opinion No. 589. Fertil Steril. 2014;101(3):633-4.
• 5. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-49.
• 6. Prescott J, Farland LV, Tobias DK, Gaskins AJ, Spiegelman D, Chavarro JE, et al. A prospective cohort study of endometriosis and subsequent risk of infertility. Hum Reprod. 2016;31(7):1475-82.
• 7. Penckofer S, Kouba J, Byrn M, Estwing Ferrans C. Vitamin D and depression: where is all the sunshine?. Issues Ment Health Nurs. 2010;31(6):385-93.
• 8. Colonese F, Laganà AS, Colonese E, Sofo V, Salmeri FM, Granese R, et al. The pleiotropic effects of vitamin D in gynaecological and obstetric diseases: an overview on a hot topic. Biomed Res Int. 2015;2015:1-11.
• 9. Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014;99(6):1137-45.
• 10. Firouzabadi RD, Rahmani E, Rahsepar M, Firouzabadi MM. Value of follicular fluid vitamin D in predicting the pregnancy rate in an IVF program. Arch Gynecol Obstet. 2014;289(1):201-6.
• 11. Franasiak JM, Molinaro TA, Dubell EK, Scott KL, Ruiz AR, Forman EJ, et al. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol. 2015;212(3):315.e1-6.
• 12. Pacis MM, Fortin CN, Zarek SM, Mumford SL, Segars JH. Vitamin D and assisted reproduction: Should vitamin D be routinely screened and repleted prior to ART? A systematic review. J Assist Reprod Genet. 2015;32(3):323-5.
• 13. Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: A systematic review. Eur J Endocrinol. 2012;166(5):765-78.
• 14. Pagliardini L, Vigano’P, Molgora M, Persico P, Salonia A, Vailati SH, et al. High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. Nutrients. 2015;7(12):9972-84.
• 15. Mariko M, Kaori K, Gentaro I, Fusako S, Tomoko M, Ayumi T, et al. Miyuki Harada Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis. J Clin Endocrinol Metab. 2016;101(6):2371-9.
• 16. Nnoaham KE, Webster P, Kumbang J, Kennedy SH, Zondervan KT. Is early age at menarche a risk factor for endometriosis? A systematic review and meta analysis of case- control studies. Fertil Steril. 2012;98(3):702-12.
• 17. Eskenazi B, Warner ML. Epidemiology of endometriosis. Obstet Gynecol Clin North Am. 1997;24(2):235-58.
• 18. Peterson CM, Johnstone EB, Hammoud AO, Stanford JB, Varner MW, Kennedy A, et al. Risk factors associated with endometriosis: importance of study population for characterizing disease in the ENDO Study. Am J Obstet Gynecol. 2013;208(6):451.e1-11.
• 19. Shah DK, Correia KF, Vitonis AF, Missmer SA. Body size and endometriosis: results from 20 years of follow-up within the Nurses’Health Study II prospective cohort. Hum Reprod. 2013;28(7):1783-92.
• 20. Zhong Y, Carmella SG, Upadhyaya P, Hochalter JB, Rauch D, Oliver A, et al. Immediate consequences of cigarette smoking: rapid formation of polycyclic aromatic hydrocarbon diol epoxides. Chem Res Toxicol. 2011;24(2):246-52.
• 21. Sangi-Haghpeykar H, Poindexter AN 3rd. Epidemiology of endometriosis among parous women. Obstet Gynecol. 1995; 85(6):983-92.
• 22. Dunn PM. Francis Glisson (1597-1677) and the "discovery" of rickets. Arch Dis Child Fetal Neonatal Ed. 1998;78(2):154-5.
• 23. Bourlev V, Volkov N, Pavlovitch S, Lets N, Larsson A, Olovsson M. The relationship between microvessel density, proliferative activity and expression of vascular endothelial growth factor‐A and its receptors in eutopic endometrium and endometriotic lesions. Reproduction. 2006;132(3):501-9.
• 24. Yildirim B, Guler T, Akbulut M, Oztekin O, Sariiz G. 1‐alpha,25‐Dihydroxyvitamin D3 regresses endometriotic implants in rats by inhibiting neovascularization and altering regulation of matrix metalloproteinase. Postgrad Med. 2014;126(1):104-10.
• 25. Holly RH, Jorge EC, Susan M, Walter CW, Stacey A. Dairy-Food, Calcium, Magnesium, and Vitamin D Intake and Endometriosis: A Prospective Cohort Study. Missmer American Journal of Epidemiology. 2013;177(5):420-30.
• 26. Zemel MB, Sun X. Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr. 2008;138(6):1047-52.
• 27. Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr. 2010;105(3):459-67.
• 28. Parazzini F, Chiaffarino F, Surace M, Chatenoud L, Cipriani S, Chiantera V, et al. Selected food intake and risk of endometriosis. Hum Reprod. 2004;19(8):1755-9.
• 29. Olovsson M. Immunological aspects of endometriosis: an update. Am J Reprod Immunol. 2011;66(1):101-4.
• 30. Tariverdian N, Theoharides TC, Siedentopf F, Gutierrez G, Jeschke U, Rabinovich GA, et al. Neuroendocrine‐immune disequilibrium and endometriosis: an interdisciplinary appoach. Semin Immunopathol. 2007;29(2):193- 210.
• 31. Igarashi M, Ikuma K, Yamada Y, Abe Y, Igarashi S, Minegishi High T. CD44 content in ovarian endometriotic cysts. Fertil Steril. 2003;80(4):1065-6.
• 32. Miyashita M, Koga K, Izumi G, Sue F, Makabe T, Taguchi A, et al. Effects of 1, 25-dihydroxy vitamin D3 on endometriosis. J Clin Endocrino Metab. 2016;101(6):2371-9.
• 33. Halder SK, Osteen KG. Al-HendyVitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and-9 in human uterine fibroid cells. Hum. Reprod. 2013;28(9):2407-16.
• 34. Mariani M, Viganò P, Gentilini D, Camisa B, Caporizzo E, Di Lucia P, et al. The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 2012; 27(7):2010-9.
• 35. Abbas MA, Taha MO, Disi AM, Shomaf M. Regression of endometrial implants treated with vitamin D3 in a rat model of endometriosis. Eur J Pharmacol. 2013;715(1-3):72-5.