Comparison of the diagnostic accuracy of CKD-EPI cystatin-C, CKD-EPI creatinine and 24-hour creatinine clearance for estimating GFR: a preliminary study

Year 2021, Volume: 46 Issue: 1, 1 - 10, 31.03.2021

Süheyl Uçucu , Durmuş Ayan

Abstract

Purpose: Serum cystatin C level is a specific marker to estimate the glomerular filtration rate (GFR). Due to this specificity, we assume that GFR estimations based on cystatin C have higher diagnostic performances than GFR estimations using other biomarkers. In this study, we aimed to compared the diagnostic performances of CKD-EPI cystatin C equation, CKD-EPI creatinine equation and 24-hour creatinine clearance to estimate GFR.
Materials and Methods: A total of 130 participants who consisting of 101 acute and chronic renal disease patients and 29 healthy volunteers, who applied to the Nephrology Clinic, have been included in our study. Their urine creatinine levels and serum creatinine levels were measured by the colorimetric-Jaffe method, and cystatin C was by the nephelometric method.
Results: There was a statistically significant relationship between CKD-EPI cystatin C, between CKD-EPI creatinine and standard creatinine clearance. The Area Under the Receiver Operating Characteristics curve (AUROC) was found to be 1, 0.995, and 0.954 respectively.
Conclusion: According to the results, we think that serum cystatin C levels will present earlier findings in GFR decrease and may be a more effective marker than serum creatinine and standard creatinine clearance in the early period.

Thanks

We would like to thank dear Metin UÇUCU and Talha KARABIYIK for their support in the preparation of this article.

GFR tahmininde CKD-EPI sistatin-C, CKD-EPI kreatinin ve 24 saatlik kreatinin klirensinin tanısal doğruluğunun karşılaştırılması: bir ön çalışma

Abstract

Amaç: Serum sistatin C düzeyi, glomerüler filtrasyon hızını (GFH) tahmin etmek için spesifik bir belirteçtir. Bu özgüllük nedeniyle, sistatin C'ye dayalı GFH tahminlerinin, diğer biyobelirteçleri kullanan GFH tahminlerinden daha yüksek tanısal performanslara sahip olduğunu varsayıyoruz. Bu çalışmada, GFH'yi tahmin etmek için CKD-EPI sistatin C denklemi, CKD-EPI kreatinin denklemi ve 24 saatlik kreatinin klirensinin tanısal performanslarını karşılaştırmayı amaçladık.
Gereç ve Yöntem: Çalışmamıza Nefroloji Kliniğine başvuran akut ve kronik böbrek hastalarından oluşan 101 hasta ve 29 sağlıklı gönüllüden oluşan toplam 130 katılımcıdâhil edildi. İdrar kreatinin düzeyleri ve serum kreatinin düzeyleri kolorimetrik-Jaffe yöntemi ile ölçülürken, sistatin C nefelometrik yöntemle ölçüldü.
Bulgular: CKD-EPI sistatin C, CKD-EPI kreatinin ve standart kreatinin klirensi arasında istatistiksel olarak anlamlı bir ilişki vardı. Alıcı Çalışma Karakteristikleri eğrisinin (AUROC) Altındaki Alan sırasıyla 1, 0.995 ve 0.954 olarak bulundu.
Sonuç: Elde edilen sonuçlara göre, serum sistatin C düzeylerinin GFH azalmasında daha erken bulgular sunacağı ve erken dönemde serum kreatinin ve standart kreatinin klirensinden daha etkili bir belirteç olabileceği kanısındayız.

Keywords

Cystatin C, CKD, CKD-EPI, Glomerular Filtration Rate, creatinine, kidney failure

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