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Evaluation of the potential drug-drug interactions at orthopedics and traumatology outpatient clinics of a tertiary care hospital

Year 2021, Volume: 46 Issue: 2, 601 - 609, 30.06.2021
https://doi.org/10.17826/cumj.865824

Abstract

Purpose: The aim of the present study is to determine the frequency and severity of possible drug-drug interactions (DDIs) in the prescriptions of patients who admitted to the orthopedics and traumatology outpatient clinics.
Materials and Methods: This cross-sectional, retrospective study analyzed the prescription data of patients that admitted to orthopedics and traumatology outpatient clinics of a tertiary care hospital from January 1, 2020 to February 15, 2020. The severity of DDIs was interpreted using the Lexi-comp® drug interaction database. Relationship between the presence of DDIs and the number of prescribed drugs were evaluated.
Results: Out of 753 patient data evaluated, a total of 2248 drugs were prescribed. Among 669 polypharmacy patients, 293 (43.8%) patients had one or more potential DDIs. A total of 437 DDIs were detected of which 300 (68.6%) were D, 82 (18.8%) were X, 49 (11.2%) were C and 6 (1.4%) were B risk category interactions. The most common DDIs were between systemic Diclofenac and topical Diclofenac, (14.4%) The presence of potential DDIs was significantly associated with adult age and female gender.
Conclusion: Although, the severity of the potential DDIs in orthopedics and traumatology outpatient clinics were generally moderate and manageable, it is crutial for physicians to be aware of the interactions between the most frequently prescribed drugs in orthopedics and traumatology outpatient clinics, monitor patients for the safe use of drugs.

References

  • Reference1. Shah BM, Hajjar ER. Polypharmacy, adverse drug reactions, and geriatric syndromes. Clin Geriatr Med. 2012; 28(2):173-186. DOI: https://doi.org/10.1016/j.cger.2012.01.002.
  • Reference2. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatrics 2017; 17: 230. DOI: https://doi.org/10.1186/s12877-017-0621-2.
  • Reference3. Abdulraheem IS. Polypharmacy: A risk factor for geriatric syndrome, morbidity & mortality. Aging Sci 2013; 1(2): e103. DOI: https://doi.org/10.4172/2329-8847.1000e103
  • Reference4. Nusair MB, Al-Azzam SI, Arabyat RM, Amawi HA, Alzoubi KH, Rabah AA. The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan. Saudi Pharmaceutical Journal 2020; 28: 155–160. DOI: https://doi.org/10.1016/j.jsps.2019.11.009.
  • Reference5. Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, et al. Potential drug-drug and drug-disease interactions in well functioning community dwelling older adults. J Clin Pharm Ther. 2017; 42(2): 228–233. DOI: https://doi.org/10.1111/jcpt.12502.
  • Reference6. De Palencia Espinosa MAF, Carrasco MSD, Soler JLF, Merino GR, De la Rubia Nieto MA, Miro AE. Pharmacoepidemiological study of drug–drug interactions in onco-hematological pediatric patients. Int J Clin Pharm 2014; 36:1160–1169. DOI: https://doi.org/10.1007/s11096-014-0011-1
  • Reference7. Al-Ramahi R, Raddad AR, Rashed AO, Bsharat A, Abu-Ghazaleh D, Yasin E, et al. Evaluation of potential drug-drug interactions among Palestinian hemodialysis patients. BMC Nephrology 2016; 17:96. DOI: https://doi.org/10.1186/s12882-016-0317-4
  • Reference8. Noor S, Ismail M, Ali Z. Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives? BMC Pharmacology and Toxicology 2019; 20:45. DOI: https://doi.org/10.1186/s40360-019-0325-7
  • Reference9. Morales-Rios O, Jasso-Gutierrez L, Reyes-Lopez A, Garduño-Espinosa J, Muñoz-Hernandez O. Potential drug-drug interactions and their risk factors in pediatric patients admitted to the emergency department of a tertiary care hospital in Mexico. PLoS ONE 2018; 13(1): e0190882. DOI: https://doi.org/10.1371/journal.pone.0190882.
  • Reference10. Fadare JO, Ajayi AE, Adeoti AO, Desalu OO, Obimakinde AM, Agboola SM. Potential drug‑drug interactions among elderly patients on anti‑hypertensive medications in two tertiary healthcare facilities in Ekiti State, South‑West Nigeria. Sahel Med J 2016; 19: 32-37. DOI: https://doi.org/10.4103/1118-8561.181896
  • Reference11. Mistry M, Gor A, Ganguly B. Potential drug-drug interactions among prescribed drugs in paediatric outpatients department of a tertiary care teaching hospital. J. Young Pharm. 2017; 9 (3): 371-375. DOI: https://doi.org/10.5530/jyp.2017.9.74
  • Reference12. Dechanont S, Maphanta S, Butthum B, Kongkaew C. Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2014; 23(5): 489-497. DOI: https://doi.org/10.1002/pds.3592.
  • Reference13. Batta A, Madan N, Kalra BS, Arora S. Prescription audit, drug utilization pattern and adverse drug reaction monitoring in outpatients of orthopedics department of tertiary care teaching hospital: a pilot study. MAMC J Med Sci 2019; 5: 77-82. DOI: https://10.4103/mamcjms.mamcjms_33_19
  • Reference14. UpToDate, Inc. Lexi-Interact Online. https://www.uptodate.com/drug-interactions/#di-druglist, 2020
  • Reference15. Solanki N, Patel Y. Drug utilization pattern and drug interaction study of antibiotics prescribed to orthopaedic patients in private hospital. Arch Pharma Pract 2019; 10(4):114-117.
  • Reference16. Motgahre VM, Bajait CS, Turankar A, Pimpalkhute A, Dholpure M. Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indications at a tertiary care hospital. Indian Journal of Pharmacy and Pharmacology 2016; 3(4); 178-181. DOI: https://doi.org/10.18231/2393-9087.2016.0007
  • Reference17. Alonso Monteiro Bezerra, M, Hellwig, N, da Rocha Castelar Pinheiro G, Souza Lopes C. Prevalence of chronic musculoskeletal conditions and associated factors in Brazilian adults – National Health Survey. BMC Public Health 2018;18: 287. DOI: https://doi.org/10.1186/s12889-018-5192-4
  • Reference18. Wijnhoven HAH, de Vet HCW, Picavet HSJ. Prevalence of musculoskeletal disorders is systematically higher in women than in men. The Clinical Journal of Pain 2006; 22(8): 717-724. DOI: https://doi.org/10.1097/01.ajp.0000210912.95664.53.
  • Reference19. Kumar A, Dalai CK, Ghosh AK, Ray M. Drug utilization study of co-administration of nonsteroidal anti-inflammatory drugs and gastroprotective agents in an orthopaedics outpatients department of a tertiary care hospital in West Bengal. Int J Basic Clin Pharmacol. 2013; 2(2): 199-202. DOI:https://doi.org/10.5455/2319-2003.ijbcp20130315
  • Reference20. Karki N, Prasad P, Joshi RR, Shrestha BK. Drug utilization pattern by using who core prescribing indicators in orthopedics and obstetrics / gynecology departments of a tertiary care hospital. Journal of Lumbini Medical College 2019;7(1):6 pages. DOI: https://doi.org/ 10.22502/jlmc.v7i1.280.
  • Reference21. Singh A, Mahendra M, Ganguly A, Meena S. Drug utilization pattern in orthopaedics tertiary care teaching hospital of central U.P. International Journal of Orthopaedics Sciences 2019; 5(4): 443-446. DOI: https://doi.org/10.22271/ortho.2019.v5.i4h.1715
  • Reference22. Yadav DK, Alam K, Sah AK, Sarraf DP. Utilization pattern of antibiotics and drug related problems in the orthopedic department at a tertiary care hospital: a prospective study. Journal of Drug Delivery and Therapeutics 2020; 10(3): 24-30 DOI: http://dx.doi.org/10.22270/jddt.v10i3.4056
  • Reference23. Moura C, Acurcio F, Belo N. Drug-drug interactions associated with length of stay and cost of hospitalization. Pharm Pharmaceut Sci 2009;12(3): 266–272. DOI: https://doi.org/10.18433/j35c7z.
  • Reference24. Rabba AK, Abu Hussein AM, Abu Sbeih BK, Nasser SI. Assessing drug-drug interaction potential among patients admitted to surgery departments in three palestinian hospitals. BioMed Research International 2020; DOI: https://doi.org/10.1155/2020/9634934
  • Reference25. Sánchez-López VA, Brennan-Bourdon LM, Rincón-Sánchez AR, Islas-Carbajal MC, Navarro-Ruíz A, Huerta-Olvera SG. Prevalence of potential drug-drug interactions in hospitalized surgical patients. Journal of Pharmacy and Pharmacology 2016; 4: 658-666. DOI: https://doi.org/10.17265/2328-2150/2016.12.002
  • Reference26. Jabeen T, Khader MA, Babu AVK, Rao AS. Study of potential drug interactions among eight major departments-general medicine, orthopedics, gynecology, pulmonology, general surgery, psychiatry, otolaryngology and dermatology of a tertiary care teaching hospıtal in Southern Indıa. International Journal of Pharmacy and Pharmaceutical Sciences 2020; 12(6): 59-67, DOI: https://doi.org/10.22159/ijpps.2020v12i6.37704.
  • Reference27. İdrizoğlu MG, Küçükibrahimoğlu E, Karaalp A, Sarikaya O, Demirkapu M, Onat F, et al. Potential drug–drug interactions in a medical intensive care unit of a university hospital. Turk J Med Sci 2016; 46: 812-819. DOI: https://doi:10.3906/sag-1504-147
  • Reference28. Olsen RM, Sletvold H. Potential drug-to-drug interactions: A cross sectional study among older patients discharged from hospital to home care. Saf. Health 2018; 4 (1): 8. DOI: https://doi.org/10.1186/s40886-018-0075-z

Üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin değerlendirilmesi

Year 2021, Volume: 46 Issue: 2, 601 - 609, 30.06.2021
https://doi.org/10.17826/cumj.865824

Abstract

Amaç: Bu çalışmanın amacı, ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçetelerinde olası ilaç-ilaç etkileşimlerinin sıklığını ve şiddetini belirlemektir.
Gereç ve Yöntem: Bu kesitsel retrospektif çalışma, 1 Ocak 2020- 15 Şubat 2020 tarihleri arasında üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçete verilerini analiz etti. İlaç-ilaç etkileşimlerinin şiddeti, Lexi-comp® ilaç etkileşimi veri tabanı kullanılarak yorumlandı. İlaç-ilaç etkileşimi varlığı ile reçetelenmiş ilaç sayısı arasındaki ilişki değerlendirildi.
Bulgular: Değerlendirilen 753 hasta verisinde toplam 2248 ilaç reçete edildi. 669 polifarmasi hastasından, 293 (%43.8) hastanın bir veya daha fazla potansiyel ilaç- ilaç etkileşimi vardı. 300’ü (%68.6) D, 82’si (%18.8) X, 49’u (%11.2) C ve 6’sı (%1.4) B risk kategorisi etkileşimleri olmak üzere toplam 437 ilaç-ilaç etkileşimi tespit edildi. En sık ilaç- ilaç etkileşimleri sistemik diklofenak ve topical diklofenak arasındaydı (%14.4). Olası ilaç-ilaç etkileşimlerinin varlığı erişkin yaş ve kadın cinsiyet ile anlamlı olarak ilişkiliydi.
Sonuç: Ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin şiddeti genel olarak orta düzeyde ve yönetilebilir olsa da, ortopedi ve travmatoloji polikliniklerinde en sık reçete edilen ilaçlar arasındaki etkileşimlerden haberdar olmak ve ilaçların güvenli kullanımı için hastaları izlemek hekimler açısından önem taşımaktadır.

References

  • Reference1. Shah BM, Hajjar ER. Polypharmacy, adverse drug reactions, and geriatric syndromes. Clin Geriatr Med. 2012; 28(2):173-186. DOI: https://doi.org/10.1016/j.cger.2012.01.002.
  • Reference2. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatrics 2017; 17: 230. DOI: https://doi.org/10.1186/s12877-017-0621-2.
  • Reference3. Abdulraheem IS. Polypharmacy: A risk factor for geriatric syndrome, morbidity & mortality. Aging Sci 2013; 1(2): e103. DOI: https://doi.org/10.4172/2329-8847.1000e103
  • Reference4. Nusair MB, Al-Azzam SI, Arabyat RM, Amawi HA, Alzoubi KH, Rabah AA. The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan. Saudi Pharmaceutical Journal 2020; 28: 155–160. DOI: https://doi.org/10.1016/j.jsps.2019.11.009.
  • Reference5. Hanlon JT, Perera S, Newman AB, Thorpe JM, Donohue JM, Simonsick EM, et al. Potential drug-drug and drug-disease interactions in well functioning community dwelling older adults. J Clin Pharm Ther. 2017; 42(2): 228–233. DOI: https://doi.org/10.1111/jcpt.12502.
  • Reference6. De Palencia Espinosa MAF, Carrasco MSD, Soler JLF, Merino GR, De la Rubia Nieto MA, Miro AE. Pharmacoepidemiological study of drug–drug interactions in onco-hematological pediatric patients. Int J Clin Pharm 2014; 36:1160–1169. DOI: https://doi.org/10.1007/s11096-014-0011-1
  • Reference7. Al-Ramahi R, Raddad AR, Rashed AO, Bsharat A, Abu-Ghazaleh D, Yasin E, et al. Evaluation of potential drug-drug interactions among Palestinian hemodialysis patients. BMC Nephrology 2016; 17:96. DOI: https://doi.org/10.1186/s12882-016-0317-4
  • Reference8. Noor S, Ismail M, Ali Z. Potential drug-drug interactions among pneumonia patients: do these matter in clinical perspectives? BMC Pharmacology and Toxicology 2019; 20:45. DOI: https://doi.org/10.1186/s40360-019-0325-7
  • Reference9. Morales-Rios O, Jasso-Gutierrez L, Reyes-Lopez A, Garduño-Espinosa J, Muñoz-Hernandez O. Potential drug-drug interactions and their risk factors in pediatric patients admitted to the emergency department of a tertiary care hospital in Mexico. PLoS ONE 2018; 13(1): e0190882. DOI: https://doi.org/10.1371/journal.pone.0190882.
  • Reference10. Fadare JO, Ajayi AE, Adeoti AO, Desalu OO, Obimakinde AM, Agboola SM. Potential drug‑drug interactions among elderly patients on anti‑hypertensive medications in two tertiary healthcare facilities in Ekiti State, South‑West Nigeria. Sahel Med J 2016; 19: 32-37. DOI: https://doi.org/10.4103/1118-8561.181896
  • Reference11. Mistry M, Gor A, Ganguly B. Potential drug-drug interactions among prescribed drugs in paediatric outpatients department of a tertiary care teaching hospital. J. Young Pharm. 2017; 9 (3): 371-375. DOI: https://doi.org/10.5530/jyp.2017.9.74
  • Reference12. Dechanont S, Maphanta S, Butthum B, Kongkaew C. Hospital admissions/visits associated with drug-drug interactions: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf. 2014; 23(5): 489-497. DOI: https://doi.org/10.1002/pds.3592.
  • Reference13. Batta A, Madan N, Kalra BS, Arora S. Prescription audit, drug utilization pattern and adverse drug reaction monitoring in outpatients of orthopedics department of tertiary care teaching hospital: a pilot study. MAMC J Med Sci 2019; 5: 77-82. DOI: https://10.4103/mamcjms.mamcjms_33_19
  • Reference14. UpToDate, Inc. Lexi-Interact Online. https://www.uptodate.com/drug-interactions/#di-druglist, 2020
  • Reference15. Solanki N, Patel Y. Drug utilization pattern and drug interaction study of antibiotics prescribed to orthopaedic patients in private hospital. Arch Pharma Pract 2019; 10(4):114-117.
  • Reference16. Motgahre VM, Bajait CS, Turankar A, Pimpalkhute A, Dholpure M. Prescription pattern and adverse drug reaction profile of drugs prescribed with focus on NSAIDs for orthopedic indications at a tertiary care hospital. Indian Journal of Pharmacy and Pharmacology 2016; 3(4); 178-181. DOI: https://doi.org/10.18231/2393-9087.2016.0007
  • Reference17. Alonso Monteiro Bezerra, M, Hellwig, N, da Rocha Castelar Pinheiro G, Souza Lopes C. Prevalence of chronic musculoskeletal conditions and associated factors in Brazilian adults – National Health Survey. BMC Public Health 2018;18: 287. DOI: https://doi.org/10.1186/s12889-018-5192-4
  • Reference18. Wijnhoven HAH, de Vet HCW, Picavet HSJ. Prevalence of musculoskeletal disorders is systematically higher in women than in men. The Clinical Journal of Pain 2006; 22(8): 717-724. DOI: https://doi.org/10.1097/01.ajp.0000210912.95664.53.
  • Reference19. Kumar A, Dalai CK, Ghosh AK, Ray M. Drug utilization study of co-administration of nonsteroidal anti-inflammatory drugs and gastroprotective agents in an orthopaedics outpatients department of a tertiary care hospital in West Bengal. Int J Basic Clin Pharmacol. 2013; 2(2): 199-202. DOI:https://doi.org/10.5455/2319-2003.ijbcp20130315
  • Reference20. Karki N, Prasad P, Joshi RR, Shrestha BK. Drug utilization pattern by using who core prescribing indicators in orthopedics and obstetrics / gynecology departments of a tertiary care hospital. Journal of Lumbini Medical College 2019;7(1):6 pages. DOI: https://doi.org/ 10.22502/jlmc.v7i1.280.
  • Reference21. Singh A, Mahendra M, Ganguly A, Meena S. Drug utilization pattern in orthopaedics tertiary care teaching hospital of central U.P. International Journal of Orthopaedics Sciences 2019; 5(4): 443-446. DOI: https://doi.org/10.22271/ortho.2019.v5.i4h.1715
  • Reference22. Yadav DK, Alam K, Sah AK, Sarraf DP. Utilization pattern of antibiotics and drug related problems in the orthopedic department at a tertiary care hospital: a prospective study. Journal of Drug Delivery and Therapeutics 2020; 10(3): 24-30 DOI: http://dx.doi.org/10.22270/jddt.v10i3.4056
  • Reference23. Moura C, Acurcio F, Belo N. Drug-drug interactions associated with length of stay and cost of hospitalization. Pharm Pharmaceut Sci 2009;12(3): 266–272. DOI: https://doi.org/10.18433/j35c7z.
  • Reference24. Rabba AK, Abu Hussein AM, Abu Sbeih BK, Nasser SI. Assessing drug-drug interaction potential among patients admitted to surgery departments in three palestinian hospitals. BioMed Research International 2020; DOI: https://doi.org/10.1155/2020/9634934
  • Reference25. Sánchez-López VA, Brennan-Bourdon LM, Rincón-Sánchez AR, Islas-Carbajal MC, Navarro-Ruíz A, Huerta-Olvera SG. Prevalence of potential drug-drug interactions in hospitalized surgical patients. Journal of Pharmacy and Pharmacology 2016; 4: 658-666. DOI: https://doi.org/10.17265/2328-2150/2016.12.002
  • Reference26. Jabeen T, Khader MA, Babu AVK, Rao AS. Study of potential drug interactions among eight major departments-general medicine, orthopedics, gynecology, pulmonology, general surgery, psychiatry, otolaryngology and dermatology of a tertiary care teaching hospıtal in Southern Indıa. International Journal of Pharmacy and Pharmaceutical Sciences 2020; 12(6): 59-67, DOI: https://doi.org/10.22159/ijpps.2020v12i6.37704.
  • Reference27. İdrizoğlu MG, Küçükibrahimoğlu E, Karaalp A, Sarikaya O, Demirkapu M, Onat F, et al. Potential drug–drug interactions in a medical intensive care unit of a university hospital. Turk J Med Sci 2016; 46: 812-819. DOI: https://doi:10.3906/sag-1504-147
  • Reference28. Olsen RM, Sletvold H. Potential drug-to-drug interactions: A cross sectional study among older patients discharged from hospital to home care. Saf. Health 2018; 4 (1): 8. DOI: https://doi.org/10.1186/s40886-018-0075-z
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Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Emine Nur Özdamar 0000-0003-0612-9000

İhsan Özdamar This is me 0000-0002-0685-9284

Publication Date June 30, 2021
Acceptance Date March 16, 2021
Published in Issue Year 2021 Volume: 46 Issue: 2

Cite

MLA Özdamar, Emine Nur and İhsan Özdamar. “Evaluation of the Potential Drug-Drug Interactions at Orthopedics and Traumatology Outpatient Clinics of a Tertiary Care Hospital”. Cukurova Medical Journal, vol. 46, no. 2, 2021, pp. 601-9, doi:10.17826/cumj.865824.