Antidepresanların ilaç ilişkili hareket bozuklukları ve cinsel yan etkiler açısından karşılaştırılması

Year 2021, Volume: 46 Issue: 2, 610 - 620, 30.06.2021

Zeynep Namlı , Lut Tamam , Mehmet Emin Demirkol , Mahmut Onur Karaytuğ , Kerim Uğur , Özge Eriş

https://doi.org/10.17826/cumj.865933

Abstract

Amaç: Çalışmamızda farklı antidepresan gruplarının cinsel yan etkiler, daha az bilinen uyku bruksizmi ve nörolojik yan etkiler açısından karşılaştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışmanın örneklem grubunu 18-50 yaş aralığında, depresif bozukluklar ve/veya anksiyete bozuklukları tanısı ile ayaktan tedavi gören, 1 aydan uzun süredir antidepresan monoterapisi alan 406 hasta oluşturmaktadır. Tüm hastalara; sosyodemografik veri formu, Hamilton Depresyon Ölçeği (HAM-D), Hamilton Anksiyete Ölçeği (HAM-A), UKU Yan Etki Değerlendirme Ölçeği nörolojik yan etkiler bölümü, Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) ve Morisky İlaç Uyum Ölçeği uygulanmıştır. Kullanılan antidepresanlar; seçici serotonin geri alım inhibitörleri (SSGİ), serotonin norepinefrin geri alım inhibitörleri (SNGİ ve vortioksetin olmak üzere üç gruba ayrılarak karşılaştırılmıştır.
Bulgular: YAB tanılı hastalarda SNGİ kullananların UKU nörolojik yan etkiler ortalama puanı SSGİ kullananlardan anlamlı olarak yüksek belirlendi. Depresif bozukluk tanılı hastalarda; ilaç tedavisine yeterli uyum sırasıyla %91.3 oranında vortioksetin, % 73.8 oranında SSGİ ve %50 oranında SNGİ kullanan hastalarda belirlendi ve üç grup arasındaki fark istatistiksel olarak anlamlıydı.
Sonuç: Antidepresan ilaç grupları bazı yan etkiler ve tedavi uyumu açısından birbirinden farklılık gösterebilmektedir. Antidepresan kaynaklı uyku bruksizmi ve hareket bozuklukları gibi daha az bilinen yan etkilerin daha iyi anlaşılması için prospektif çalışmalara ihtiyaç bulunmaktadır.

Keywords

antidepresan, cinsel disfonksiyon, nörolojik yan etki, tedavi uyumu, uyku bruksizmi

Supporting Institution

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Project Number

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Thanks

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Comparison of antidepressant in terms of drug-related movement disorders and sexual side effects

Abstract

Purpose: The aim of this study was to compare different antidepressant groups regarding sexual side effects, sleep bruxism, and neurological side effects.
Materials and Methods: We included 406 patients between 18 and 50 years old, who were treated as an outpatient with a diagnosis of depressive disorders or anxiety disorders and had antidepressant monotherapy for more than one month. We applied sociodemographic data form, Hamilton Depression Scale (HDS), Hamilton Anxiety Scale (HAS), neurological side effects section of the UKU Side Effect Rating Scale, Arizona Sexual Experiences Scale (ASEX), and Morisky Medication Adherence Scale to all patients. We divided the antidepressants into three groups as selective serotonin reuptake inhibitors (SSRI), serotonin-norepinephrine reuptake inhibitors (SNRI) and vortioxetine.
Results: The mean score of the UKU neurological side effects of those using SNRI in patients with GAD was significantly higher than those using SSRI. Adequate adherence to drug treatment was 91.3% for vortioxetine users, 73.8% for SSRI users, and 50% for SNRI users in patients with depressive disorder, and the difference between the three groups was statistically significant.
Conclusion: Antidepressant drug groups may differ from each other regarding some side effects and treatment adherence. Prospective studies are needed to understand better lesser-known side effects such as antidepressant-induced sleep bruxism and movement disorders.

Keywords

antidepressant, sexual dysfunction, side effects, bruxism

Project Number

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