Research Article
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Comparison of topical acyclovir and penciclovir in recurrent herpes labialis treatment

Year 2021, Volume: 46 Issue: 3, 927 - 933, 30.09.2021
https://doi.org/10.17826/cumj.899262

Abstract

Purpose: The aim of this study is to compare the effects of acyclovir and penciclovir creams in the treatment of recurrent herpes labialis.
Materials and Methods: Seventy patients with pre-diagnosed recurrent herpes labialis lesions were enrolled in this study. Diagnosis was confirmed with HSV-1 IgM antibody test. Patients were separated under 2 treatment groups as acyclovir and penciclovir cream. Both agents were applied until complete healing of the lesions was seen. Burning, itching and bleeding scores; time of erythema, vesicles, ulceration, crusting and crust loss of the lesions were recorded. Pain values of the patients were recorded using a visual analog scale (VAS) and DASS-21 scale was used to measure emotional state related to depression, anxiety and stress.
Results: Pain level in the acyclovir group was significantly lower than the penciclovir group in the 3rd day, though with no difference in the following days. DASS-21 scores revealed signs of depression on 62.8% of the patients, anxiety on 34.2% of the patients, and stress on 41.4% of the patients in moderate or higher levels. While the pain level was higher in patients with high anxiety severity, it was observed that the pain level was low in patients with high stress intensity.
Conclusion: Although it is not possible to cure recurrent herpes labialis completely, any methods and drugs that shorten the healing time of the lesion and reduce pain and discomfort gains importance. Our study showed that acyclovir is superior in reducing pain.

Supporting Institution

This work was supported by the Gaziantep University Scientific Research Projects Coordination Unit

Project Number

DHF.UT.19.01

References

  • 1. Whitley RJ, Kimberlin DW, Roizman B. Herpes simplex viruses. Clin Infect Dis. 1998;26(3):541–53.
  • 2. Looker KJ, Magaret AS, May MT, Turner KME, Vickerman P, Gottlieb SL, et al. Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PLoS One. 2015;10(10):e0140765.
  • 3. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001;357(9267):1513–8.
  • 4. Andrews C, Camichael E. A Note on the Presence of Antibodies to Herpes Virus. In Post-Encephalitic and Other Human Sera. Lancet. 1930;215(5564):857–8.
  • 5. Honarmand M, Farhadmollashahi L, Vosoughirahbari E. Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis. J Clin Exp Dent. 2017;9(6):e729–32.
  • 6. Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y, et al. Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J Oral Pathol Med. 2017;46(8):561–8.
  • 7. Vere Hodge RA, Field HJ. Antiviral agents for herpes simplex virus. Adv Pharmacol. 2013;67:1–38.
  • 8. Emmert DH. Treatment of common cutaneous herpes simplex virus infections. Am Fam Physician. 2000;61(6):1697–704.
  • 9. Aronson JK, editor. Aciclovir. Meyler’s Side Effects of Drugs. Elsevier B.V.; 2016. 53–57 p.
  • 10. Femiano F, Gombos F, Scully C. Recurrent herpes labialis: Efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir). Oral Dis. 2001;7(1):31–3.
  • 11. Opstelten W, Neven A, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008;54(12):1683–7.
  • 12. Schmidt DD, Zyzanski S, Ellner J, Kumar ML, Arno J. Stress as a precipitating factor in subjects with recurrent herpes labialis. J Fam Pract. 1985;20(4):359–66.
  • 13. Schmidt DD, Schmidt PM, Crabtree BF, Hyun J, Anderson P, Smith C. The temporal relationship of psychosocial stress to cellular immunity and herpes labialis recurrences. Fam Med. 1991;23(8):594–9.
  • 14. Ortego G, Villafañe JH, Doménech-García V, Berjano P, Bertozzi L, Herrero P. Is there a relationship between psychological stress or anxiety and chronic nonspecific neck-arm pain in adults? A systematic review and meta-analysis. J Psychosom Res. 2016;90:70–81.
  • 15. Chiu TTW, Lam PKW. The prevalence of and risk factors for neck pain and upper limb pain among secondary school teachers in Hong Kong. J Occup Rehabil. 2007;17(1):19–32.
  • 16. Michaelides A, Zis P. Depression, anxiety and acute pain: links and management challenges. Postgrad Med. 2019;131(7):438–44.
  • 17. Tsuboi Y, Ueda Y, Naruse F, Ono R. The Association between Perceived Stress and Low Back Pain among Eldercare Workers in Japan. J Occup Environ Med. 2017;59(8):765–7.
  • 18. Bonzini M, Bertu’ L, Veronesi G, Conti M, Coggon D, Ferrario MM. Is musculoskeletal pain a consequence or a cause of occupational stress? A longitudinal study. Int Arch Occup Environ Health. 2015;88(5):607–12.
  • 19. Alperovitch-Najenson D, Katz-Leurer M, Santo Y, Golman D, Kalichman L. Upper body quadrant pain in bus drivers. Arch Environ Occup Heal. 2010;65(4):218–23.

Rekürrent herpes labialisin tedavisinde topikal asiklovir ve pensiklovir etkinliklerinin karşılaştırılması

Year 2021, Volume: 46 Issue: 3, 927 - 933, 30.09.2021
https://doi.org/10.17826/cumj.899262

Abstract

Giriş: Bu çalışmanın amacı, rekürrent herpes labialisin topikal tedavisinde asiklovir ve pensiklovir etken madde içeren kremlerin etkilerini karşılaştırmaktır.
Gereç ve Yöntem: Çalışmamıza rekürrent herpes labialis tanı konmuş lezyonu olan 70 hasta dahil edildi. Teşhis HSV-1 IgM antikor testi ile doğrulandı. Hastalar asiklovir ve pensiklovir etken maddesi içeren kremlerin kullanıldığı iki tedavi grubuna ayrıldı. Her iki ajan lezyonlarda tam iyileşme görülene kadar uygulandı. Yanma, kaşıntı ve kanama skorları; lezyonların kızarıklık, vezikül, ülserasyon, kabuklanma ve kabuk kaybı zamanları kaydedildi. Hastaların ağrı değerleri görsel analog skala (VAS) ile kaydedildi ve depresyon, anksiyete ve stres ile ilgili duygusal durumu ölçmek için DASS-21 skalası kullanıldı.
Bulgular: Asiklovir grubundaki ağrı düzeyi, sadece üçüncü günde pensiklovir grubuna göre anlamlı derecede düşüktü. DASS-21 skorları, hastaların %62,8'inde depresyon, %34,2'sinde anksiyete ve %41,4'ünde orta ve yüksek düzeyde stres belirtisi gösterdi. Anksiyete şiddeti yüksek hastalarda ağrı düzeyleri yüksek iken, stres yoğunluğu yüksek hastalarda ağrı düzeyinin düşük olduğu görüldü.
Sonuç: Rekürrent herpes labialisin tamamen tedavisi mümkün olmamakla birlikte lezyonun iyileşme süresini kısaltan, ağrı ve rahatsızlığı azaltan her türlü yöntem ve ilaç önem kazanmaktadır. Bu bağlamda çalışmamız, asiklovir etken madde içeren ajanın, ağrıyı azaltmada pensiklovir etken maddesi içeren ajana göre daha üstün olduğunu göstermiştir.

Project Number

DHF.UT.19.01

References

  • 1. Whitley RJ, Kimberlin DW, Roizman B. Herpes simplex viruses. Clin Infect Dis. 1998;26(3):541–53.
  • 2. Looker KJ, Magaret AS, May MT, Turner KME, Vickerman P, Gottlieb SL, et al. Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PLoS One. 2015;10(10):e0140765.
  • 3. Whitley RJ, Roizman B. Herpes simplex virus infections. Lancet. 2001;357(9267):1513–8.
  • 4. Andrews C, Camichael E. A Note on the Presence of Antibodies to Herpes Virus. In Post-Encephalitic and Other Human Sera. Lancet. 1930;215(5564):857–8.
  • 5. Honarmand M, Farhadmollashahi L, Vosoughirahbari E. Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis. J Clin Exp Dent. 2017;9(6):e729–32.
  • 6. Chen F, Xu H, Liu J, Cui Y, Luo X, Zhou Y, et al. Efficacy and safety of nucleoside antiviral drugs for treatment of recurrent herpes labialis: a systematic review and meta-analysis. J Oral Pathol Med. 2017;46(8):561–8.
  • 7. Vere Hodge RA, Field HJ. Antiviral agents for herpes simplex virus. Adv Pharmacol. 2013;67:1–38.
  • 8. Emmert DH. Treatment of common cutaneous herpes simplex virus infections. Am Fam Physician. 2000;61(6):1697–704.
  • 9. Aronson JK, editor. Aciclovir. Meyler’s Side Effects of Drugs. Elsevier B.V.; 2016. 53–57 p.
  • 10. Femiano F, Gombos F, Scully C. Recurrent herpes labialis: Efficacy of topical therapy with penciclovir compared with acyclovir (aciclovir). Oral Dis. 2001;7(1):31–3.
  • 11. Opstelten W, Neven A, Eekhof J. Treatment and prevention of herpes labialis. Can Fam Physician. 2008;54(12):1683–7.
  • 12. Schmidt DD, Zyzanski S, Ellner J, Kumar ML, Arno J. Stress as a precipitating factor in subjects with recurrent herpes labialis. J Fam Pract. 1985;20(4):359–66.
  • 13. Schmidt DD, Schmidt PM, Crabtree BF, Hyun J, Anderson P, Smith C. The temporal relationship of psychosocial stress to cellular immunity and herpes labialis recurrences. Fam Med. 1991;23(8):594–9.
  • 14. Ortego G, Villafañe JH, Doménech-García V, Berjano P, Bertozzi L, Herrero P. Is there a relationship between psychological stress or anxiety and chronic nonspecific neck-arm pain in adults? A systematic review and meta-analysis. J Psychosom Res. 2016;90:70–81.
  • 15. Chiu TTW, Lam PKW. The prevalence of and risk factors for neck pain and upper limb pain among secondary school teachers in Hong Kong. J Occup Rehabil. 2007;17(1):19–32.
  • 16. Michaelides A, Zis P. Depression, anxiety and acute pain: links and management challenges. Postgrad Med. 2019;131(7):438–44.
  • 17. Tsuboi Y, Ueda Y, Naruse F, Ono R. The Association between Perceived Stress and Low Back Pain among Eldercare Workers in Japan. J Occup Environ Med. 2017;59(8):765–7.
  • 18. Bonzini M, Bertu’ L, Veronesi G, Conti M, Coggon D, Ferrario MM. Is musculoskeletal pain a consequence or a cause of occupational stress? A longitudinal study. Int Arch Occup Environ Health. 2015;88(5):607–12.
  • 19. Alperovitch-Najenson D, Katz-Leurer M, Santo Y, Golman D, Kalichman L. Upper body quadrant pain in bus drivers. Arch Environ Occup Heal. 2010;65(4):218–23.
There are 19 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Mustafa Can Gürbüz This is me 0000-0001-5392-7238

Necmettin Kırtak This is me 0000-0002-3789-0612

Betül Taş Özyurtseven 0000-0002-8174-388X

Project Number DHF.UT.19.01
Publication Date September 30, 2021
Acceptance Date May 5, 2021
Published in Issue Year 2021 Volume: 46 Issue: 3

Cite

MLA Gürbüz, Mustafa Can et al. “Comparison of Topical Acyclovir and Penciclovir in Recurrent Herpes Labialis Treatment”. Cukurova Medical Journal, vol. 46, no. 3, 2021, pp. 927-33, doi:10.17826/cumj.899262.