Perilipin-5 as a potential new biomarker in patients with liver disease and impaired De Ritis ratio

Year 2021, Volume: 46 Issue: 4, 1321 - 1326, 30.12.2021

İbrahim Ethem Şahin Ceyhan Hacıoğlu Fatih Davran Merve Alpay

https://doi.org/10.17826/cumj.975899

Abstract

Purpose: Liver dysfunctions are one of the most prevalent and deadly diseases worldwide. The De Ritis ratio, which is obtained by proportioning serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT), has been suggested to be a precious marker to assess the prognosis of liver diseases. This study was to investigate the relationship between perilipin 5 (PLIN5) levels and De Ritis ratio in patients with liver disease.
Materials and Methods: There were 3 groups: control (Group1; n=20), hepatic patients with normal De Ritis ratio (Group2; n=35) and hepatic patients with impaired De Ritis ratio (Group3; n=35). De Ritis rates of all patients were determined according to the serum aspartate aminotransferase (AST)/serum alanine aminotransferase (ALT) results. Additionally, PLIN5 was spectrophotometrically analyzed from serum samples.
Results: There is no significant difference between the groups in terms of age and gender. PLIN5 levels increased by 2.6 and 3.8 times in Group2 and Group3, respectively. De Ritis ratio was significantly increased in the Group3 compared the control, and enhanced PLIN5 levels was correlated with De Ritis ratio in the Group3. There was a significant positive correlation between De Ritis ratio and PLIN5 levels.
Conclusion: PLIN5 levels together with De Ritis rate in liver patients may be used as a prognostic marker. Furthermore, this relationship could be a useful method in the follow-up of liver diseases.

Keywords

De Ritis ratio, Perilipin5, Liver damage, AST, ALT

Karaciğer hastalığı ve bozulmuş De Ritis oranı olan hastalarda potansiyel yeni bir biyobelirteç olarak perilipin-5

Abstract

Amaç: Karaciğer fonksiyon bozuklukları dünya çapında en yaygın ve ölümcül hastalıklardan biridir. Serum aspartat aminotransferaz (AST) ve serum alanin aminotransferazın (ALT) oranlanmasıyla elde edilen De Ritis oranının, karaciğer hastalıklarının prognozunu değerlendirmek için değerli bir belirteç olduğu öne sürülmüştür. Bu çalışma, karaciğer hastalığı olan hastalarda perilipin 5 (PLIN5) düzeyleri ile De Ritis oranı arasındaki ilişkiyi araştırmak amacıyla yapılmıştır.
Gereç ve Yöntem: Kontrol (Grup1; n=20), normal De Ritis oranı olan karaciğer hastaları (Grup2; n=35) ve De Ritis oranı bozulmuş karaciğer hastaları (Grup3; n=35) olmak üzere 3 grup vardı. Tüm hastaların De Ritis oranları serum aspartat aminotransferaz (AST) / serum alanin aminotransferaz (ALT) sonuçlarına göre belirlendi. Ek olarak, PLIN5, serum örneklerinden spektrofotometrik olarak analiz edildi.
Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı fark yoktu. PLIN5 seviyeleri Grup2 ve Grup3'te sırasıyla 2,6 ve 3,8 kat arttı. De Ritis oranı, kontrole kıyasla Grup3'te önemli ölçüde arttı ve artan PLIN5 seviyeleri, Grup3'teki De Ritis oranı ile korele idi. De Ritis oranı ile PLIN5 seviyeleri arasında anlamlı pozitif korelasyon vardı.
Sonuç: Karaciğer hastalarında De Ritis oranı ile birlikte PLIN5 düzeyleri, prognostik bir belirteç olarak kullanılabilir. Ayrıca bu ilişki karaciğer hastalıklarının takibinde faydalı bir yöntem olabilir.

Keywords

De Ritis oranı, Perilipin5, Karaciğer hasarı, AST, ALT

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