Uyku kalitesi ve geriatrik 8 (G8) skorunun multiple myelomlu yaşlı hastalarda kemoterapi ile değişimleri

Year 2021, Volume: 46 Issue: 4, 1574 - 1580, 30.12.2021

Mahmut Bakır Koyuncu , Çağatay Çavuşoğlu , Anıl Tombak , Mehmet Ali Uçar , Aydan Akdeniz , Eyüp Naci Tiftik

Abstract

Amaç: Bu çalışmada multipl miyelomlu yaşlı hastaların kemoterapi öncesi ve sonrası uyku kalitesini değerlendirmeyi ve uyku kalitesini etkileyen faktörleri araştırmayı amaçladık.
Gereç ve Yöntem: Yeni tanı konmuş Multipl miyelomlu toplam 108 hasta çalışmaya dahil edildi. Hastaların tanı anında Geriatrik 8 (G8) ve Pittsburgh Uyku Kalitesi İndeksi skorları hesaplandı ve bu skorlardaki değişiklikler üç kür kemoterapi sonrası değerlendirildi.
Bulgular: Hastaların 63'ünde (%58,3) tanı anında uyku bozukluğu vardı. Kemoterapiden sonra uyku bozukluğu oranının %41.7'ye düştüğü görüldü. Tedavi öncesi ve sonrası toplam G8 skorunda istatistiksel olarak anlamlı bir fark yoktu. Lojistik regresyon analizlerinde serum kalsiyum düzeyi, tedavi öncesi G8 skoru ve kemoterapiye yanıtın uyku kalitesinin belirleyicileri olduğu görüldü. Kemoterapiye iyi yanıt veren hastalarda uyku kalitesindeki artış anlamlı olarak daha yüksekti.
Sonuç: Uyku bozuklukları, multipl miyelomlu yaşlı hastalarda yaygın bir sorundur. Çalışmamız kemoterapi ile uyku kalitesinin arttığını ve uyku kalitesi düşük hastaların tedaviye yanıtlarının daha kötü olduğunu gösterdi. Bu nedenle bu hastaların uyku kalitesini artıracak önlemlere ve tedavilere ihtiyaç vardır.

Keywords

multiple myelom, uyku kalitesi, geriatrik değerlendirme

Changes in sleep quality and geriatric-8 (G8) score with chemotherapy in older patients with multiple myeloma

Abstract

Purpose: The aim of this study was to evaluate the sleep quality of older patients with multiple myeloma before and after chemotherapy and investigate factors affecting sleep quality.
Materials and Methods: A total of 108 patients with newly diagnosed multiple myeloma were included in the study. Geriatric 8 (G8) and Pittsburgh Sleep Quality Index scores were calculated for the patients at the time of diagnosis, and the changes in these scores were evaluated after three cycles of chemotherapy.
Results: At the time of diagnosis, 63 (58.3%) of the patients had sleep disturbances. The sleep disturbance rate decreased to 41.7% after chemotherapy. There was no statistically significant difference in the total G8 score before and after treatment. In logistic regression analyses, the serum calcium level, pre-treatment G8 score, and response to chemotherapy were predictors of sleep quality. Increases in sleep quality were significantly higher in patients with good responses to chemotherapy.
Conclusion: Sleep disturbances are a common problem in older patients with multiple myeloma. Our study demonstrated that sleep quality increased with chemotherapy, and patients with low sleep quality had worse responses to treatment. Therefore, there is a need for measures and treatments to increase the sleep quality of these patients.

Keywords

Multiple myeloma, sleep quality, geriatric scores

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