Hastanede yatan Covid-19 pnömoni hastalarında hipokaleminin klinik sonuçlara etkileri

Year 2021, Volume: 46 Issue: 4, 1650 - 1656, 30.12.2021

Bülent Kaya Saime Paydas Tolga Kuzu Omer Demiroglu Sevinç Püren Yücel Karakaya Mustafa Balal Yeşim Taşova

https://doi.org/10.17826/cumj.989230

Cited By: 1

Abstract

Amaç: Çalışmamızda hastanede yatan Covid-19 pnömonili hastalarda hipokaleminin klinik sonuçlar üzerindeki etkilerini araştırdık.
Gereç ve Yöntem: Tek merkezli retrospektif çalışmada, hastanede yatan covid-19 pnömonili hastaların demografik ve klinik özellikleri ile birlikte hastanenin ilk günündeki laboratuvar sonuçları kaydedildi. Hastaların hastanede yatış süreleri, mekanik ventilasyon dahil yoğun bakım gereksinimi ve sağ kalım süreleri belirlendi.
Bulgular: Çalışmamıza yaş ortalaması 64 ± 14.5 (23-90) olan 111 erkek (% 60) olmak üzere 185 hasta dahil edildi. Hastalar hipokalemik (%16.8) ve normokalemik (%83.2) olarak 2 gruba ayrıldı. Diyabetik hasta sayısı normokalemik grupta daha fazlaydı. Hipokalemik grupta serum total protein ve albümin düzeyleri daha düşük, alkalen fosfataz, gama-glutamil transpeptidaz, total bilirubin, direkt bilirubin, kan pH'sı ve bikarbonat düzeyi daha yüksekti. Çoklu lojistik regresyon analizinde alkaloz hipokalemi riskini 5.73 kat artırdı. Hastanede yatış süresi, yoğun bakım gereksinimi ve hastane mortalitesi hipokalemi ve normokalemi hastalarında benzerdi.
Sonuç: Covid-19 pnömoni hastalarında ilk başvuruda hipokalemi %16.8 gibi oldukça yüksek oranda bulunmuştur. Hipokalemi metabolik alkaloz ile ilişkiliydi ancak hastanede kalış süresi, mekanik ventilasyon dahil yoğun bakım gereksinimi ve hastane mortalitesi ile ilişkili değildi.

Keywords

COVİD-19, Hipokalemi, Mortalite

Supporting Institution

yok

Project Number

yok

Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia

Abstract

Purpose: We investigated the effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia.
Materials and Methods: In this single-center retrospective study, we recorded characteristics of hospitalized covid-19 pneumonia patients and laboratory test results on the first hospital day. Duration of hospitalization, requiring intensive care including mechanical ventilation and survival, were determined.
Results: Our study included 185 patients and of them 111 male (60% male) patients with mean age of 64 ± 14.5 (23-90). Patients were grouped as hypokalemic (16.8%) and normokalemic patients (83.2%). The number of diabetic patients was higher in the normokalemic group. Serum total protein and albumin levels were lower in hypokalemic group, while alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, blood pH and bicarbonate level were higher. In multiple logistic regression analyses, alkalosis increased risk of hypokalemia 5.73 times. Duration of hospitalization, requirement of intensive care and hospital mortality were similar in hypokalemia and normokalemia patients.
Conclusion: In patients with Covid-19 pneumonia, hypokalemia has been found to be quite common as high as 16.8% at the first presentation. Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.

Keywords

COVIP-19, Hypokalemia, Mortality

Project Number

yok

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