Quantitative assessment of visceral and subcutaneous fat with hepatosteatosis by computed tomography in metabolic syndrome

Year 2022, Volume: 47 Issue: 2, 481 - 488, 30.06.2022

Mehmet Maruf Aydın , Emine Dağıstan , Zeliha Coşgun

https://doi.org/10.17826/cumj.1037220

Abstract

Purpose: We aimed to evaluate visceral and subcutaneous fat tissue and its association with hepatosteatosis on computed tomography (CT) scans to determine cut-off criteria for metabolic syndrome, measure abdominal obesity directly based on the visceral fat tissue area (VFTA) rather than indirectly based on waist circumference and obtain supportive findings by density measurements in addition to the VFTA measurements.
Materials and Methods: The Hounsfield unit (HU) values, visceral, subcutaneous fat areas and HU values of 108 patients diagnosed with metabolic syndrome (MS) were determined according to the National Cholesterol Education Program Adult Treatment Panel III 2001 Criteria by retrospectively analyzing their abdominal CT images taken for various reasons. The relationships of the obtained values with each other and to MS were evaluated.
Results: The strongest predictor of MS was VFTA, and 156.47 cm² was the most significant value with 74.1% sensitivity and 58.6% specificity. An HU value of -102.99 for visceral fat tissue density (VFTD) was found as the second most significant finding with 75% sensitivity and 57.6% specificity. The VFTA values of the patients with hepatosteatosis were higher, and increased VFTA values were associated with lower VFTD values.
Conclusion: The most important supportive finding was the demonstration of the possibility of measuring abdominal obesity, which has an important place among criteria, directly by measuring VFTA, rather than indirectly based on waist circumference. 

Keywords

Metabolic syndrome, Computed tomography, Hepatosteatosis, Visceral fatty tissue, subcutaneous fatty tissue

Supporting Institution

YOK

Thanks

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Metabolik sendromda visseral ve subkutan yağ miktari ve hepatosteatozun bilgisayarli tomografi ile kantitatif değerlendirilmesi

Abstract

Amaç: Bu çalışmada, metabolik sendrom hastalarında bilgisayarlı tomografi ile visseral ve subkutan yağlı doku alanı, dansitesi ve karaciğer yağlanmasında eşik değerleri elde etmek, metabolik sendromla vücut yağ dağılımı ve hepatosteatoz ilişkisini değerlendirmek amaçlandı .
Gereç ve Yöntem: Çeşitli nedenlerle çekilmiş kontrastsız abdomen bilgisayarlı tomografi (BT) görüntüleri retrospektif olarak taranıp National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATPIII)-2001 kriterlerine göre Metabolik sendrom tanılı 108 hastanın karaciğere yönelik Hounsfield Unit (HU) değeri, visseral, subkutan yağ doku alanı ve HU değerleri, Osirix Dicom Viewer programı ile belirlendi. Elde edilen değerlerin birbiri ve metabolik sendromla ilişkisi değerlendirildi.
Bulgular: En güçlü prediktör visseral yağlı doku alanı (VYDA) bulunmuş olup 156.47 cm² değerinin %74.1 sensitivite ve %58.6 spesifiteye sahip en anlamlı değer olduğu saptanmıştır. Ayrıca visseral yağlı doku dansitesi (VYDD) için -102.99 HU değeri %75 sensitivite, %57.6 spesifite ile ikinci en önemli bulgu olarak saptanmıştır. Hepatosteatoz saptanan hastalarda VYDA’nın daha fazla olduğu ve VYDA artışı ile birlikte VYDD’nin de daha düşük dansitede ölçüldüğü saptanmıştır.
Sonuç: En önemli destekleyici bulgu: kriterler içinde en önemli yere sahip olan abdominal obezitenin indirek olarak bel çevresi ile değil direk olarak visseral yağlı doku alanının ölçülebilmesi ile gösterilmesi olmuştur. 

Keywords

Metabolik sendrom, bilgisayarlı tomografi, hepatosteatoz, visseral yağlı doku.

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