Meme kanserinde strain elastografi ile histopatolojik parametreler arasındaki ilişki

Year 2022, Volume: 47 Issue: 4, 1663 - 1669, 28.12.2022

Mahmut Çoraplı Hacı Taner Bulut Ayşe Gül Örmeci Hüseyin Alakuş

https://doi.org/10.17826/cumj.1131781

Cited By: 1

Abstract

Amaç: Bu çalışmanın amacı strain elastografinin invaziv meme kanserinde immünhistokimyasal, histolojik grade ve moleküler subtiplendirmeyle ilişkisini değerlendirmektir
Gereç ve Yöntem: Neadjuvan tedavi almamış meme koruyucu cerrahi geçirmiş 171 hastanın (yaş ortalaması 46.871 ± 11.949 yıl) elastosonografi indeksi değerleri ile progesteron reseptörü, östrojen reseptörü, insan epidermal büyüme faktörü reseptörü 2, Ki-67, histolojik grade ve moleküler subtipi arasındaki ilişki değerlendirildi. Elastografi indeksini değerlendirmek için strain elastosonografisi kullanıldı.
Bulgular: Hastaların yaş ortalaması 46.871 ± 11.949 yıldı. östrojen reseptörü-pozitif, progesteron reseptörü-pozitif ve insan epidermal büyüme faktörü (HER-2)reseptörü 2 pozitif hasta sayısı sırasıyla 135, 129 ve 90 olarak bulundu. 47 hastanın histolojik derecesi en kötüydü. Moleküler alt tiplendirmeye göre 25 (%14,5), 29 (%17,0), 109 (%63,7) ve 8 (%4,7) hasta sırayla HER-2-pozitif, luminal A, luminal B ve triple negatif olarak sınıflandırıldı. Bu meme rezeksiyonu vakaları arasında elastografi indeks değerleri ile östrojen reseptörü, progesteron reseptörü, insan epidermal büyüme faktörü reseptörü 2, Ki-67, histolojik derece veya moleküler alt tip arasında istatistiksel olarak anlamlı bir korelasyon yoktu.
Sonuç:. Elastografi indeksi değeri belirtilen histopatolojik parametreleri ön görmede yetersizdir.

Keywords

Sonoelastografi, meme, malignite, histopatoloji

Relationship between strain elastography and histopathological parameters in breast cancer

Abstract

Purpose: This study aimed to evaluate the relationship between strain elastography and immunohistochemical markers, the histologic grade, and molecular subtyping in invasive breast cancer.
Materials and Methods: The relationships between the elastography index values and progesterone receptor, estrogen receptor, human epidermal growth factor receptor 2, Ki-67, the histologic grade, and molecular subtype in 171 patients who had not received neoadjuvant treatment and underwent breast-conserving surgery were evaluated. Strain elastosonography were used to evaluate elastography index.
Results: The mean patient age was 46.871 ± 11.949 years. There were 135, 129, and 90 estrogen receptor-positive, progesterone receptor-positive, and human epidermal growth factor receptor 2-positive patients, respectively. Forty-seven patients had the worst histological grade. Based on molecular subtyping, human epidermal growth factor receptor 2-positive, luminal A, luminal B, and triple-negative classifications were made for 25 (14.5%), 29 (17.0%), 109 (63.7%), and 8 (4.7%) cases, respectively. There was no statistically significant correlation between the elastography index values and estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, histologic grade, or molecular subtype among these breast resection cases.
Conclusion: The elastography index value was insufficient to predict the specified histopathological parameters.

Keywords

Sonoelastography, breast, malignancy, histopathology

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