Preterm yenidoğanlarda gebelik yaşına göre küçük olmak ile tiroid fonksiyon testleri arasındaki ilişki

Year 2022, Volume: 47 Issue: 4, 1656 - 1662, 28.12.2022

Duran Yıldız , Ufuk Çakır , Ali Ulaş Tuğcu , Cüneyt Tayman

https://doi.org/10.17826/cumj.1171931

Abstract

Amaç: Bu çalışmada erken doğmuş, gebelik yaşına göre küçük (SGA) bebeklerde tiroid hormon düzeyleri ile klinik sonuçlar arasındaki ilişkiyi değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: Prematüre yenidoğanlar (gebelik yaşı ≤30 hafta) SGA olan ve olmayan olarak iki gruba ayrıldı. Gruplar arasında tiroid uyarıcı hormon (TSH) ve serbest tiroksin (sT4) düzeyleri, konjenital hipotiroidizm (KH) sıklığı, demografik ve klinik özellikler, morbidite ve mortalite oranları karşılaştırıldı.
Bulgular: SGA grubunda 72 ve SGA olmayan grupta 358 olmak üzere toplam 430 prematüre yenidoğan dahil edildi. KH sıklığı, morbidite, demografik ve klinik özellikler iki grup arasında benzerdi. Mortalite oranı SGA'da (%36,1) SGA olmayan gruptan (%13,6) daha yüksekti. Serum sT4 düzeyi SGA grubunda (1,04±0,30 ng/dl) SGA olmayan gruba göre (1,24±0,33 ng/dl) daha düşüktü. Serum TSH düzeyi SGA grubunda (9,91 ± 5,6 uIU/L), SGA olmayan gruptan (6,6 ± 5,2 uIU/L) daha yüksekti.
Sonuç: Tiroid disfonksiyonu sıklığı, geçici olarak yüksek TSH ve düşük fT4 konsantrasyonlarına bağlı olarak, preterm SGA bebeklerde SGA olmayanlara kıyasla daha yüksekti. Bu nedenle erken doğmuş ve SGA bebeklerde tiroid fonksiyon testleri periyodik olarak izlenmelidir.

Keywords

serbest tiroksin, bebek, prematüre, gebelik yaşına göre küçük bebek, tiroid uyarıcı hormone

Supporting Institution

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Thanks

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Relationship between thyroid function tests and small for gestational age in preterm newborns

Abstract

Purpose: The aim of this study was to evaluate the relationship between thyroid hormone levels and clinical outcomes in preterm, small for gestational age (SGA) infants.
Materials and Methods: The premature newborns (gestational age of ≤30 weeks) were divided into two groups as SGA and non-SGA. Thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels, the frequency of congenital hypothyroidism (CH), demographic and clinical characteristics, morbidity and mortality rate were compared between the groups.
Results: A total of 430 premature newborns, 72 in the SGA group and 358 in the non-SGA group were included. The frequency of CH, morbidity, demographic and clinical characteristics were similar between two groups. The mortality rate was higher in SGA (36.1%) than in non-SGA group (13.6%). Serum fT4 level was lower in SGA group (1.04±0.30 ng/dl) compared to the non-SGA group (1.24±0.33 ng/dl). The serum TSH level was higher in SGA group (9.91 ± 5.6 uIU/L) than in non-SGA group (6.6 ± 5.2 uIU/L).
Conclusion: The frequency of thyroid dysfunction was higher in preterm SGA infants compared to non-SGA, which was due to transiently high TSH and low fT4 concentrations. Therefore, thyroid function tests should be monitored periodically in preterm and SGA infants.

Keywords

free thyroxine, infant, premature, small for gestational age, thyroid stimulating hormone

Project Number

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