Akut koroner sendrom hastalarında C-reaktif protein/albümin oranı ile aort ark kalsifikasyonu arasındaki ilişki

Year 2024, Volume: 49 Issue: 2, 382 - 390, 30.06.2024

Uğur Köktürk Fahri Çakan

https://doi.org/10.17826/cumj.1438569

Abstract

Amaç: Akut koroner sendrom (AKS) hastalarında aortik ark kalsifikasyonunun ciddiyeti (AAC) ile C-reaktif protein/Albümin oranı (CAR) arasındaki ilişkiyi değerlendirdik.
Gereç ve Yöntem: AKS ile başvuran ve koroner anjiyografi yapılan 288 hasta analize dahil edildi. CAR serum CRP/albümin x 10 olarak hesaplandı. AAC dört gruba ayrıldı (0 ila 3): Grade 0-1 AAC, ciddi olmayan AAC grubu olarak; grade 2-3 AAC olanlar ise ciddi AAC grubu olarak tanımlandı.
Bulgular: CRP ve CAR, ciddi AAC grubunda, ciddi olmayan AAC grubuna göre anlamlı derecede yüksekti. Çok değişkenli analiz, AKS hastalarında ciddi AAC'nin bağımsız bir belirleyicisi olarak CAR ve yaşın pozitif ilişkili olduğunu belirledi. Eğri altındaki CAR alanı (AUC) ve CRP AUC, albümin seviyesine kıyasla paralel eğriler gösterdi ve bu da daha yüksek istatistiksel anlamlılığa işaret ettiğini gösterdi. Albüminin AUC'si 0,349'du (%95 GA: 0,286-0,413). CAR için AUC 0,695, %95 GA 0,625 ila 0,753, CRP için AUC 0,684 (%95 GA: 0,620-0,748) idi. CAR kesme değerine (1,664) göre 2 gruba ayrıldıktan sonra, ciddi AAC oranı, yüksek CAR hastalarında düşük CAR hastalarına kıyasla önemli ölçüde daha sık görüldü (%56,7 vs %23,7).
Sonuç: Kolayca hesaplanabilen, tekrarlanabilir ve geçerli bir inflamasyon belirteci olan CAR, AKS hastalarında ciddi AAC'yi öngörmek için güvenilir bir şekilde kullanılabilir.

Keywords

C-reaktif protein, aortik ark kalsifikasyonu, akut koroner sendrom

The association between C-reactive protein/albumin ratio and aortic arch calcification in acute coronary syndrome patients

Abstract

Purpose: We evaluated the association between the severity of aortic arch calcification (AAC) and C-reactive protein/albumin ratio (CAR) in acute coronary syndrome (ACS) patients.
Materials and Methods: 288 patients who presented with ACS and underwent coronary angiography were enrolled analysis. CAR was calculated as serum CRP/albumin x 10. The AAC was separated into four groups (0 to 3): Grade 0-1 AAC was defined as the non-severe AAC group, and those with grade 2-3 AAC were defined as the severe AAC group.
Results: CRP and CAR were significantly higher in the severe AAC group than in the non-severe AAC group. Multivariate analysis determined that CAR and age were positively associated in ACS patients as an independent predictor of severe AAC. CAR area under the curve (AUC) and CRP AUC demonstrated parallel curves compared to albumin levels, indicating higher statistical significance. The AUC for albumin was 0.349 (95% CI: 0.286-0.413). The AUC for CAR was 0.695, 95% CI 0.625 to 0.753, for CRP the AUC was 0.684 (95% CI: 0.620-0.748). After stratification into 2 groups according to the CAR cut-off value (1.664), the rate of severe AAC was importantly often in high CAR patients compared to in low CAR patients (56.7% vs 23.7%).
Conclusion: CAR, an easily calculable, repeatable, and valid surrogate marker of inflammation, can be used reliably to indicate severe AAC in ACS patients.

Keywords

C-Reactive protein, acute myocardial infarction, aortic arch calcification

Ethical Statement

The retrospective study was approved by the Karabuk University ethic committee (number: 2023/1276, day: 27.02.2023).

Supporting Institution

The authors declare that this study received no financial support

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