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Trigliserit-glukoz aterojenik prediktör indeksi ile santral retinal arter oklüzyonu arasındaki ilişki

Year 2024, Volume: 49 Issue: 3, 696 - 702, 30.09.2024
https://doi.org/10.17826/cumj.1492273

Abstract

Amaç: Santral retinal arter tıkanıklığı (CRAO), ciddi görme kaybına neden olan akut bir iskemik olaydır ve daha ileri serebrovasküler ve kardiyovasküler olayların habercisidir. Trigliserid-glikoz indeksi (TyG), sağlıklı bireylerde insülin direncini gösterir. Çok sayıda araştırma, TyG indeksini metabolik sendrom, hipertansiyon ve yeni başlayan diyabetle ilişkilendirir. Son araştırmalar ayrıca, kardiyovasküler hastalıklarda ateroskleroz belirtisi olarak rolünü ve vasküler hasarı değerlendirmede potansiyel klinik önemi olduğunu ileri sürmektedir. Bu çalışmada, CRAO ve TyG indeksi arasındaki ilişki değerlendirilmiştir.
Gereç ve Yöntem: Bu vaka kontrol çalışmasına Ocak 2018'den Mart 2023'e kadar hastanemizde 116 yetişkin (50 CRAO hastası ve kronik göz hastalığı olmayan 66 kontrol deneği) katılmıştır. TyG indeksi ln[açlık TG (mg/dL) × açlık plazma glikozu (mg/dL)/2] olarak formüle edilmiştir.
Bulgular: CRAO grubunun ortalama yaşı 65,0±14,7 yıldı ve 27 (%55,1 54) kadın vardı. Kontrol grubunun ortalama yaşı 61,2±12,1 yıldı ve 32 (%48,5) kadın vardı. Ortalama TyG indeksi CRAO grubunda 9,05±0,7 ve kontrollerde 8,7±0,7 idi ve istatistiksel olarak anlamlı bir farktı. Tek değişkenli regresyon analizi, TyG indeksi ve CRAO arasında bir ilişki olduğunu gösterdi (OR=2,04; CI: 1,11-3,73). Bu ilişki, çok değişkenli lojistik regresyon analizinde anlamlılığını korudu (OR=1,88; CI: 1,01-3,50).
Sonuç: Bu çalışma, aterojenik bir gösterge olan TyG indeksinin CRAO hastalarında kontrollerle karşılaştırıldığında anlamlı derecede daha yüksek olduğunu saptadık.

References

  • Lee KE, Tschoe C, Coffman SA, Kittel C, Brown PA, Vu Q et al. Management of acute central retinal artery occlusion, a "retinal stroke": an institutional series and literature review. J Stroke Cerebrovasc Dis. 2021;30:105531.
  • Liu W, Bai D, Kou L. Progress in central retinal artery occlusion: a narrative review. J Int Med Res. 2023;51:3000605231198388.
  • Tobalem S, Schutz JS, Chronopoulos A. Central retinal artery occlusion - rethinking retinal survival time. BMC Ophthalmol. 2018;18:101.
  • Dattilo M, Biousse V, Newman NJ. Update on the management of central retinal artery occlusion. Neurol Clin. 2017;35:83-100.
  • Farris W, Waymack JR. Central retinal artery occlusion. In. StatPearls. Treasure Island (FL) StatPearls, 2023.
  • da Silva A, Caldas APS, Hermsdorff HHM et al. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019;18:89.
  • Won KB, Park GM, Lee SE et al. Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. Lipids Health Dis. 2018;17:268.
  • Thai PV, Tien HA, Van Minh H, Valensi P. Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2020;19:137.
  • Tao LC, Xu JN, Wang TT, Hua F, Li JJ. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21:68.
  • Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008;61:1234-40.
  • Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613-9.
  • Naharci MI, Veizi BGY, Katipoglu B, Tasci I. Psychological burden among community-dwelling older adults with and without a history of a recent Covid-19 infection. Clin Gerontol. 2022;45:120-9.
  • Katipoglu B, Naharci MI. Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? Aging Clin Exp Res. 2022;34:1819-26.
  • Sanchez N, Draheim M. Evaluation of two competing methods for calculating Charlson's comorbidity index when analyzing short-term mortality using administrative data. J Clin Epidemiol. 1997;50:903-8.
  • Charlson ME, Carrozzino D, Guidi J, Patierno C. Charlson comorbidity index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91:8-35.
  • Poirrier JE, Meyers JL, Nagar SP, Patterson BJ, Glasser LI, Jabbour SA. Herpes zoster incidence and burden in adults with type 2 diabetes in the U.S.: a retrospective database analysis. Diabetes Care. 2022;45:2585-93.
  • Park K, Ahn CW, Lee SB, Kang S, Nam JS, Lee BK et al. Elevated TyG index predicts progression of coronary artery calcification. Diabetes Care. 2019;42:1569-73.
  • Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogates for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6:299-304.
  • Wang X, Xu W, Song Q, Zhao Z, Meng X, Xia C et al. Association between the triglyceride-glucose index and severity of coronary artery disease. Cardiovasc Diabetol. 2022;21:168.
  • Irace C, Carallo C, Scavelli F, De Franceschi MS, Esposito T, Tripolino C et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int J Clin Pract. 2013;67:665-72.
  • Lee EY, Yang HK, Lee J, Kang B, Yang Y, Lee SH et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 2016;15:155.
  • Özkalaycı F, Karagöz A, Karabay CY, Tanboga İH, Türkyılmaz E, Saygı M et al. Prognostic value of triglyceride/glucose index in patients with ST-segment elevation myocardial infarction. Biomark Med. 2022;16:613-22.
  • Tao LC, Xu JN, Wang TT, Hua F, Li JJ. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21:68.
  • Baydar O, Kilic A, Okcuoglu J, Apaydin Z, Can MM. The triglyceride-glucose index, a predictor of insulin resistance, is associated with subclinical atherosclerosis. Angiology. 2021;72:994-1000.
  • Tian X, Zuo Y, Chen S, Liu Q, Tao B, Wu S et al. Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort. Cardiovasc Diabetol. 2021;20:19.
  • Abay RN, Katipoğlu Z. The correlation between pseudoexfoliation syndrome and the Triglyceride-Glucose index. Graefe's Archive for Clinical and Experimental Ophthalmology. 2022;260:3903-8.
  • Dumitrascu OM, Newman NJ, Biousse V. Thrombolysis for central retinal artery occlusion in 2020: time is vision! J Neuroophthalmol. 2020;40:333-45.
  • Nickels TJ, Manlapaz MR, Farag E. Perioperative visual loss after spine surgery. World J Orthop. 2014;5:100-6.
  • Practice advisory for perioperative visual loss associated with spine surgery: an updated report by the American Society of Anesthesiologists Task Force on perioperative visual loss. Anesthesiology. 2012;116:274-85.
  • Dattilo M, Newman NJ, Biousse V. Acute retinal arterial ischemia. Ann Eye Sci. 2018;3:28.
  • Hayreh SS, Podhajsky PA, Zimmerman MB. Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology. 2009;116:1928-36.
  • Uppuluri A, Xia T, Zarbin MA, Bhagat N. Risk factors for central retinal artery occlusion in young patients. Can J Ophthalmol. 2021;56:270-2.
  • Lo WJ, Lin YC, Chang HY, Chen MJ. Risk factors for ocular neovascularization after central retinal artery occlusion. J Chin Med Assoc. 2022;85:880-5

The association between triglyceride-glucose atherogenic predictor index and central retinal artery occlusion

Year 2024, Volume: 49 Issue: 3, 696 - 702, 30.09.2024
https://doi.org/10.17826/cumj.1492273

Abstract

Purpose: Central retinal artery occlusion (CRAO) is an acute ischemic event causing severe visual loss and is a precursor to further cerebrovascular and cardiovascular events. The triglyceride-glucose index (TyG) indicates insulin resistance in healthy individuals. Numerous research links the TyG index to metabolic syndrome, hypertension, and new-onset diabetes. Recent research also suggests its role as a sign of atherosclerosis in cardiovascular diseases, with potential clinical significance in assessing vascular damage. In this study, the relationship between CRAO and TyG index was evaluated.
Materials and Methods: This case-control study involved 116 adults (50 CRAO patients and 66 control subjects without chronic eye diseases) at our hospital from January 2018 to March 2023. The TyG index was formulated as ln[fasting TG (mg/dL) × fasting plasma glucose (mg/dL)/2].
Results: The CRAO group had a mean age of 65.0±14.7 years, with 27 (55.1 % 54) females. The control group had a mean age of 61.2±12.1 years, with 32 (48.5) females. The mean TyG index was 9.05±0.7 in the CRAO group and 8.7±0.7 in controls, a statistically significant difference. Univariate regression analysis showed an association between the TyG index and CRAO (OR=2.04; CI: 1.11-3.73). This association remained significant in multivariate logistic regression analysis (OR=1.88; CI: 1.01-3.50).
Conclusion: This study found a significantly higher mean TyG index, an atherogenic indicator, in CRAO patients compared to controls.

References

  • Lee KE, Tschoe C, Coffman SA, Kittel C, Brown PA, Vu Q et al. Management of acute central retinal artery occlusion, a "retinal stroke": an institutional series and literature review. J Stroke Cerebrovasc Dis. 2021;30:105531.
  • Liu W, Bai D, Kou L. Progress in central retinal artery occlusion: a narrative review. J Int Med Res. 2023;51:3000605231198388.
  • Tobalem S, Schutz JS, Chronopoulos A. Central retinal artery occlusion - rethinking retinal survival time. BMC Ophthalmol. 2018;18:101.
  • Dattilo M, Biousse V, Newman NJ. Update on the management of central retinal artery occlusion. Neurol Clin. 2017;35:83-100.
  • Farris W, Waymack JR. Central retinal artery occlusion. In. StatPearls. Treasure Island (FL) StatPearls, 2023.
  • da Silva A, Caldas APS, Hermsdorff HHM et al. Triglyceride-glucose index is associated with symptomatic coronary artery disease in patients in secondary care. Cardiovasc Diabetol. 2019;18:89.
  • Won KB, Park GM, Lee SE et al. Relationship of insulin resistance estimated by triglyceride glucose index to arterial stiffness. Lipids Health Dis. 2018;17:268.
  • Thai PV, Tien HA, Van Minh H, Valensi P. Triglyceride glucose index for the detection of asymptomatic coronary artery stenosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2020;19:137.
  • Tao LC, Xu JN, Wang TT, Hua F, Li JJ. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21:68.
  • Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol. 2008;61:1234-40.
  • Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613-9.
  • Naharci MI, Veizi BGY, Katipoglu B, Tasci I. Psychological burden among community-dwelling older adults with and without a history of a recent Covid-19 infection. Clin Gerontol. 2022;45:120-9.
  • Katipoglu B, Naharci MI. Could neutrophil-to-lymphocyte ratio predict mortality in community-dwelling older people with delirium superimposed on dementia? Aging Clin Exp Res. 2022;34:1819-26.
  • Sanchez N, Draheim M. Evaluation of two competing methods for calculating Charlson's comorbidity index when analyzing short-term mortality using administrative data. J Clin Epidemiol. 1997;50:903-8.
  • Charlson ME, Carrozzino D, Guidi J, Patierno C. Charlson comorbidity index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91:8-35.
  • Poirrier JE, Meyers JL, Nagar SP, Patterson BJ, Glasser LI, Jabbour SA. Herpes zoster incidence and burden in adults with type 2 diabetes in the U.S.: a retrospective database analysis. Diabetes Care. 2022;45:2585-93.
  • Park K, Ahn CW, Lee SB, Kang S, Nam JS, Lee BK et al. Elevated TyG index predicts progression of coronary artery calcification. Diabetes Care. 2019;42:1569-73.
  • Simental-Mendía LE, Rodríguez-Morán M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogates for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008;6:299-304.
  • Wang X, Xu W, Song Q, Zhao Z, Meng X, Xia C et al. Association between the triglyceride-glucose index and severity of coronary artery disease. Cardiovasc Diabetol. 2022;21:168.
  • Irace C, Carallo C, Scavelli F, De Franceschi MS, Esposito T, Tripolino C et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int J Clin Pract. 2013;67:665-72.
  • Lee EY, Yang HK, Lee J, Kang B, Yang Y, Lee SH et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 2016;15:155.
  • Özkalaycı F, Karagöz A, Karabay CY, Tanboga İH, Türkyılmaz E, Saygı M et al. Prognostic value of triglyceride/glucose index in patients with ST-segment elevation myocardial infarction. Biomark Med. 2022;16:613-22.
  • Tao LC, Xu JN, Wang TT, Hua F, Li JJ. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21:68.
  • Baydar O, Kilic A, Okcuoglu J, Apaydin Z, Can MM. The triglyceride-glucose index, a predictor of insulin resistance, is associated with subclinical atherosclerosis. Angiology. 2021;72:994-1000.
  • Tian X, Zuo Y, Chen S, Liu Q, Tao B, Wu S et al. Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort. Cardiovasc Diabetol. 2021;20:19.
  • Abay RN, Katipoğlu Z. The correlation between pseudoexfoliation syndrome and the Triglyceride-Glucose index. Graefe's Archive for Clinical and Experimental Ophthalmology. 2022;260:3903-8.
  • Dumitrascu OM, Newman NJ, Biousse V. Thrombolysis for central retinal artery occlusion in 2020: time is vision! J Neuroophthalmol. 2020;40:333-45.
  • Nickels TJ, Manlapaz MR, Farag E. Perioperative visual loss after spine surgery. World J Orthop. 2014;5:100-6.
  • Practice advisory for perioperative visual loss associated with spine surgery: an updated report by the American Society of Anesthesiologists Task Force on perioperative visual loss. Anesthesiology. 2012;116:274-85.
  • Dattilo M, Newman NJ, Biousse V. Acute retinal arterial ischemia. Ann Eye Sci. 2018;3:28.
  • Hayreh SS, Podhajsky PA, Zimmerman MB. Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology. 2009;116:1928-36.
  • Uppuluri A, Xia T, Zarbin MA, Bhagat N. Risk factors for central retinal artery occlusion in young patients. Can J Ophthalmol. 2021;56:270-2.
  • Lo WJ, Lin YC, Chang HY, Chen MJ. Risk factors for ocular neovascularization after central retinal artery occlusion. J Chin Med Assoc. 2022;85:880-5
There are 33 citations in total.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Research
Authors

Zeynep Katipoğlu 0000-0002-6935-3221

Meydan Turan 0000-0001-6593-9025

Publication Date September 30, 2024
Submission Date May 31, 2024
Acceptance Date August 27, 2024
Published in Issue Year 2024 Volume: 49 Issue: 3

Cite

MLA Katipoğlu, Zeynep and Meydan Turan. “The Association Between Triglyceride-Glucose Atherogenic Predictor Index and Central Retinal Artery Occlusion”. Cukurova Medical Journal, vol. 49, no. 3, 2024, pp. 696-02, doi:10.17826/cumj.1492273.