Tip 1 diyabet mellitus hastalığının demir metabolizması ve hepsidin düzeyi üzerine etkileri

Year 2025, Volume: 50 Issue: 3, 654 - 660, 30.09.2025

Bekir Ay , Can Acıpayam , Nurten Seringeç Akkeçeci , Fatih Temiz , Fatma İnanç Tolun

https://doi.org/10.17826/cumj.1660974

Abstract

Amaç: Bu çalışmanın amacı daha iyi ve kötü metabolik kontrole sahip tip 1 diabetes mellitus (T1DM) hastalarında demir metabolizması, hepsidin ve hemoglobin A1c (HbA1c) arasındaki ilişkiyi ortaya koymaktır.
Gereç ve Yöntem: Çalışmaya kötü metabolik kontrole sahip 30 T1DM hastası (HbA1c değeri >%7,5), daha iyi metabolik kontrole sahip 30 T1DM hastası (HbA1c değeri ≤%7,5) ve benzer yaş ve cinsiyete sahip 30 sağlıklı kontrol dahil edildi. Rutin, hemogram, biyokimyasal testler, demir, transferin ve ferritin düzeyleri değerlendirildi.
Bulgular: Kötü metabolik hasta grubunun hepsidin seviyesi (519,52±114,58) kontrol grubundan (431,94±124,05) anlamlı olarak yüksekti. Kötü metabolik hasta grubunun ferritin seviyesi (52,10±36,53) daha iyi metabolik hasta grubundan (35,13±36,18) ve kontrol grubundan anlamlı olarak yüksekti (28,63±18,08). HbA1c ile hepsidin ve ferritin arasında pozitif ilişkiler bulundu. Alıcı çalışma karakteristiği (ROC) analizinde, hepsidin 445,20 eşik değerindeydi ve T1DM'yi teşhis etmede %61,7 duyarlılık ve %56,0 özgüllüğe sahipti.
Sonuç: Hepsidin ve ferritin düzeylerinin T1DM hastalarında arttığı ve her ikisinin de HbA1c ile pozitif korelasyon gösterdiği gösterilmiştir. Hepsidin T1DM hastalığının takibine ve teşhisine katkıda bulunan umut verici bir belirteç olabilir.

Keywords

Anahtar kelimeler: Tip 1 diabetes mellitus , hepsidin , demir metabolizması

Project Number

KSU Scientific Research Projects supported this work (2022/3-18 D).

Effects of Type 1 diabetes mellitus disease on iron metabolism and hepcidin level abstract

Abstract

Purpose: The aim of this study was to reveal the relationship between iron metabolism, hepcidin, and hemoglobin A1c (HbA1c) in type 1 diabetes mellitus (T1DM) patients with better and poor metabolic control.
Materials and Methods: The study included 30 T1DM patients with poor metabolic control (HbA1c value >7.5%), 30 T1DM patients with better metabolic control (HbA1c value ≤7.5%), and 30 healthy controls who were of similar age and gender. Routine, hemogram, biochemical tests, iron, transferrin, and ferritin levels were evaluated.
Results: The hepcidin level of the poor metabolic patient group (519.52±114.58) was significantly higher than the control group (431.94±124.05). The ferritin level of the poor metabolic patient group (52.10±36.53) was significantly higher than that of the better metabolic patient group (35.13±36.18) and the control group (28.63±18.08). Positive relationships were found between HbA1c and hepcidin and ferritin. In receiver operating characteristic (ROC) analysis, hepcidin was at the threshold value of 445.20 and had 61.7% sensitivity and 56.0% specificity in diagnosing T1DM.
Conclusion: Hepcidin and ferritin levels have been shown to increase in T1DM patients and both show a positive correlation with HbA1c. Hepcidin may be a promising marker contributing to the follow-up and diagnosis of T1DM.

Keywords

Type 1 diabetes mellitus , hepcidin , iron metabolism

Ethical Statement

The KSU Clinical Research Ethics Committee approved this work (2021/17-03).

Supporting Institution

KSU Scientific Research Projects supported this work (2022/3-18 D).

Project Number

KSU Scientific Research Projects supported this work (2022/3-18 D).

Thanks

KSU Scientific Research Projects supported this work (2022/3-18 D).

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