Sarcoptes scabiei paraziti üzerine sirkenin etkisi: in vitro öldürücü aktivitesi

Year 2025, Volume: 50 Issue: 3, 930 - 936, 30.09.2025

İlkay Can , Aslan Yürekli , Ayşenur Botsali , Ercan Çalışkan , Tuğba Tehci

https://doi.org/10.17826/cumj.1766908

Abstract

Amaç: Bu çalışmanın amacı, %100, %50 ve %25 konsantrasyonlarındaki sirkenin Sarcoptes scabiei’ye karşı in vitro skabisidal etkilerini araştırmak ve etkinliğini %5 permetrin ile karşılaştırarak alternatif bir tedavi seçeneği olma potansiyelini değerlendirmektir.
Gereç ve Yöntem: Toplam 50 sağlam ve hareketli Sarcoptes scabiei akarı çalışmaya dahil edildi. Akarlar, dermoskopi eşliğinde 22G iğne kullanılarak hastaların tünellerinden çıkarıldı ve yalnızca bütünlüğü bozulmamış ve aktif hareket eden bireyler seçildi. Beş grup değerlendirildi: Grup I (%100 sirke), Grup II (%50 sirke), Grup III (%25 sirke), Grup IV (%5 permetrin; pozitif kontrol) ve Grup V (yağ immersiyonu; negatif kontrol). Yaşam süresi, akarın çözeltiye maruz kalma anından hareketinin tamamen durmasına kadar geçen süre olarak tanımlandı ve bu süreç dijital mikroskopla gerçek zamanlı olarak izlendi. Her grupta 10 akar incelendi.
Bulgular: Grup I’de (%100 sirke; 0,6 ± 0,1 dk), Grup II’de (%50 sirke; 11,8 ± 1,4 dk) ve Grup IV’te (%5 permetrin; 336 ± 37,2 dk) maruziyetten sonraki ilk sekiz saat içinde tüm Sarcoptes scabiei akarlarının ölümü gerçekleşti. Buna karşılık, Grup III’te (%25 sirke; 1782 ± 87,9 dk) ve Grup V’te (yağ immersiyonu; 1836 ± 82,3 dk) akarlar sekizinci saatte canlılığını korudu. Hem seyretilmemiş hem de %50 oranında seyreltilmiş sirke, diğer gruplara kıyasla belirgin derecede daha yüksek skabisidal aktivite gösterdi.
Sonuç: Seyretilmemiş sirke irritan kontakt dermatit riski taşımaktadır. Bununla birlikte, %50 oranında seyreltilmiş üzüm sirkesi belirgin skabisidal etkinliğini korumakta, %5 permetrinden anlamlı derecede yüksek öldürücü etki göstermekte ve aynı zamanda cilt iritasyonu riskini azaltarak daha güvenli bir alternatif oluşturma potansiyeli taşımaktadır.

Keywords

Uyuz , Sarcoptes scabiei , Sirke , İrritan dermatit , İn vitro

The effect of vinegar on the Sarcoptes scabiei parasite: in vitro killing activity

Abstract

Purpose: The aim of this study was to evaluate the in vitro scabicidal activity of vinegar at concentrations of 100%, 50%, and 25%, and to compare its efficacy with 5% permethrin to determine its potential as an alternative therapeutic option
Materials and Methods: A total of 50 intact and motile Sarcoptes scabiei mites were included. The mites were extracted from patients’ burrows under dermoscopic guidance using a 22G needle, and only intact, actively moving specimens were selected. Five groups were tested: Group I (100% vinegar), Group II (50% vinegar), Group III (25% vinegar), Group IV (5% permethrin; positive control), and Group V (oil immersion; negative control). Survival time was defined as the interval from exposure to the test solution until the complete cessation of mite movement, and this was monitored in real time using a digital microscope. Ten mites were evaluated in each group.
Results: In Group I (100% vinegar; 0.6 ± 0.1 min), Group II (50% vinegar; 11.8 ± 1.4 min), and Group IV (5% permethrin; 336 ± 37.2 min), complete mortality of Sarcoptes scabiei was achieved within the first eight hours of exposure. In contrast, mites in Group III (25% vinegar; 1782 ± 87.9 min) and Group V (oil immersion; 1836 ± 82.3 min) remained viable at the 8-hour evaluation. Both undiluted and 50% vinegar exhibited markedly greater scabicidal activity compared with the other groups.
Conclusion: Although undiluted vinegar carries a risk of irritant contact dermatitis, 50% diluted grape vinegar retains substantial scabicidal efficacy. It exhibited a significantly greater killing effect compared with 5% permethrin while simultaneously reducing the risk of skin irritation, thereby representing a potentially safer alternative.

Keywords

Scabies , Sarcoptes scabiei , Vinegar , Irritant dermatitis , In vitro

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