Research Article
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EFFECT OF ALEXIDINE DIHYDROCHLORIDE ON THE BOND STRENGTH OF RESIN-BASED SEALER TO DENTIN

Year 2022, Volume: 32 Issue: 1, 53 - 57, 15.02.2022
https://doi.org/10.17567/ataunidfd.995849

Abstract

Abstract
Objective: To evaluate the bond strength of resin-based sealer to dentin after using different final irrigation solutions, one of which is alexidine dihydrochloride (ALX).
Methods: A total of 90 human maxillary central teeth were used. The groups were designed according to the final irrigation solution applied, as follows: Group 1: 17% ethylenediamine tetra-acetic acid (EDTA), Group 2: QMix, Group 3: 2% chlorhexidine gluconate (CHX), Group 4: 1% ALX, and Group 5: Distilled water (Control group). All canals were obturated with gutta-percha and AH Plus. For bonding strength measurement, three horizontal sections of 2 mm thickness were obtained from each sample towards the coronal to apical. Push-out force was applied until bond failure occurred. Modes of failure were classified by examining each sample using a stereomicroscope as follows: adhesive (sealer-dentin or sealer-gutta-percha interface), cohesive (failure within sealer or dentin), mixed (failure in both the sealer and dentin). The Kruskal-Wallis H test was used for comparison among the groups (P < .05).
Results: The mean highest values were obtained from the coronal, middle and apical regions, respectively
(P < .05). The highest significant values for bonding strength was obtained in the EDTA group and the lowest in the control group (P < .001). There are no statistical differences among QMix, CHX and ALX groups, except for the coronal third, where the bond strength for the QMix was higher compared to the other two groups
(P = .001). All samples showed the cohesive failure type in most.
Conclusion: Bonding strength is high when EDTA is used in any of the three parts of the root canal. ALX showed similar bond strengths to CHX.
Key Words: AH Plus, alexidine, bond strength, chlorhexidine, EDTA, Qmix
Aleksi̇di̇n di̇hi̇droklorürün rezi̇n esaslı kanal patının bağlanmasına etki̇si̇
ÖZ
Amaç: Bu çalışmanın amacı aralarında aleksidin dihidroklorürün (ALX) de bulunduğu farklı final irrigasyon solüsyonları kullanımı sonrası rezin esaslı kök kanal patının dentine bağlanma dayanımını değerlendirmektir.
Yöntemler: 90 adet insan üst birinci keser dişi kullanıldı. Uygulanan son yıkama solüsyonuna göre gruplar şu şekilde oluşturuldu: Grup 1: 17% EDTA, Grup 2: QMix, Grup 3: %2 CHX, Grup 4: %1 ALX, Grup 5: Distile su (kontrol grubu). Tüm kanallar güta-perka ve AH Plus ile dolduruldu. Bağlanma dayanımı ölçümü için her bir örnekten koronalden apikale doğru 2 mm kalınlıkta üç yatay kesit elde edildi. Bağlantıda kopma oluşana kadar push-out kuvveti uygulandı. Bağlantı başarısızlığı, her bir örnek stereomikroskop ile değerlendirilerek şu şekilde sınıflandı: Adeziv (pat-dentin ya da pat-güta-perka arayüzünde), koheziv (pat ya da dentin arayüzünde), karma (hem pat hem dentinde). Gruplar arası karşılaştırmalar Kruskal-Wallis H testi ile yapıldı (P < .05).
Bulgular: En yüksek ortalama bağlanma dayanımı değerleri sırasıyla koronal, orta ve apikal bölgede görüldü
(P < .05). En yüksek ortalama bağlanma dayanımı değeri etilendiamin tetra-asetik asit (EDTA), en düşük kontrol grubundaydı (P < .001). Qmix’in, CHX ve ALX’le kıyaslandığında daha yüksek değer gösterdiği koronal bölge dışında, bu üç grup arasında farklılık yoktu. Tüm örneklerde en fazla koheziv başarısızlık görüldü.
Sonuç: EDTA kullanıldığında kök kanalının her üç bölümünde de bağlanma dayanımı en yüksekti. ALX, CHX ile benzer bağlanma dayanımları gösterdi.
Anahtar Kelimeler: AH Plus, aleksidin, bağlanma dayanımı, klorheksidin, EDTA, Qmix

References

  • 1. Hülsmann M, Peters OA, Dummer PM. Mechanical preparation of root canals: shaping goals, techniques and means. Endod Topics. 2005;10(1):30-76.
  • 2. Torabinejad M, Handysides R, Khademi AA, Bakland LK. Clinical implications of the smear layer in endodontics: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):658-666.
  • 3. Kandaswamy D, Venkateshbabu N. Root canal irrigants. J Conservative Dent. 2010;13(4):256.
  • 4. Basrani BR, Manek S, Sodhi RN, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod. 2007;33(8):966-969.
  • 5. Chhabra R, Huff J, Haseman J, Elwell M, Peters A. Carcinogenicity of p-chloroaniline in rats and mice. Food Chemical Toxicol. 1991;29(2):119-124.
  • 6. Stojicic S, Shen Y, Qian W, Johnson B, Haapasalo M. Antibacterial and smear layer removal ability of a novel irrigant, QMiX. Int Endod J. 2012;45(4):363-371.
  • 7. Barrios R, Ferrer-Luque CM, Arias-Moliz MT, Ruiz-Linares M, Bravo M, Baca P. Antimicrobial substantivity of alexidine and chlorhexidine in dentin. J Endod. 2013;39(11):1413-145.
  • 8. Kasikci E, Aydemir E, Yogurtcu BM, Sahin F, Bayrak OF. Repurposing of Alexidine Dihydrochloride as an Apoptosis Initiator and Cell Cycle Inhibitor in Human Pancreatic Cancer. Anticancer Agents Med Chem. 2020;20(16):1956-1965.
  • 9. Wang C, Niederstrasser H, Douglas PM, et al. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun. 2017;8(1):2270.
  • 10. da Silva TM, Alves FR, Lutterbach MT, Paiva MM, Ferreira DC. Comparison of antibacterial activity of alexidine alone or as a final ir56rigant with sodium hypochlorite and chlorhexidine. BDJ Open. 2018;4:18003.
  • 11. Jain K, Agarwal P, Jain S, Seal M, Adlakha T. Alexidine versus chlorhexidine for endodontic irrigation with sodium hypochlorite. Eur J Dent. 2018;12(3):398-402.
  • 12. Akisue E, Tomita VS, Gavini G, Poli de Figueiredo JA. Effect of the combination of sodium hypochlorite and chlorhexidine on dentinal permeability and scanning electron microscopy precipitate observation. J Endod. 2010;36(5):847-850.
  • 13. Czopik B, Ciechomska M, Zarzecka J, Góra M, Woźniakiewicz M. Insight into the Reaction of Alexidine with Sodium Hypochlorite: A Potential Error in Endodontic Treatment. Molecules. 2021;26(6):1623.
  • 14. Varadan P, Ganesh A, Konindala R, Nagendrababu V, Ashok R, Deivanayagam K. Comparison of the Antibacterial Efficacy of Alexidine and Chlorhexidine Against Enterococcus Faecalis: An in Vitro Study. Cureus. 2017;9(10):e1805.
  • 15. Zorko M, Jerala R. Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. J Antimicrobial Chemotherapy. 2008;62(4):730-737.
  • 16. Jagtap P, Mishra R, Khanna S, et al. Mechanistic Evaluation of Lipopolysaccharide-Alexidine Interaction Using Spectroscopic and in Silico Approaches. ACS Infect Dis. 2018;4(11):1546-1552.
  • 17. Surender LR, Shikha A, Swathi A, Manaswini C, Habeeb A, Prabha SS. Alexidine: a Safer and an Effective Root Canal Irrigant than Chlorhexidine. J Clin Diagn Res. 2017;11(7):Zc18-zc21.
  • 18. Silveira LF, Baca P, Arias-Moliz MT, Rodríguez-Archilla A, Ferrer-Luque CM. Antimicrobial activity of alexidine alone and associated with N-acetylcysteine against Enterococcus faecalis biofilm. Int J Oral Sci. 2013;5(3):146-149.
  • 19. Kim HS, Zhu Q, Baek SH, et al. Chemical interaction of alexidine and sodium hypochlorite. J Endod. 2012;38(1):112-116.
  • 20. Thomas AR, Mani R, Reddy TV, Ravichandran A, Sivakumar M, Krishnakumar S. Evaluation of the Antibacterial Efficiency of a Combination of 1% Alexidine and Sodium Hypochlorite on Enterococcus faecalis Biofilm Models: An In Vitro Study. J Contemp Dent Pract. 2019;20(9):1090-1094.
  • 21. Mamouei Z, Alqarihi A, Singh S, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018;3(5):e00539.
  • 22. Sharp G, Green S, Rose M. Chlorhexidine-induced anaphylaxis in surgical patients: a review of the literature. ANZ J Surg. 2016;86(4):237-243.
  • 23. Alizadeh H, Neelam S, Cavanagh HD. Amoebicidal activities of alexidine against 3 pathogenic strains of acanthamoeba. Eye Contact Lens. 2009;35(1):1-5.
  • 24. Kermeoglu F, Aksoy U, Kalender A, Oztan MD, Oguz EI, Kıyan M. Determination of the Minimum Inhibitory Concentrations of Alexidine and Chlorhexidine Against Enterococcus faecalis and Candida albicans: An In Vitro Study. Cureus. 2018;10(2):e2221.
  • 25. Neelakantan P, Subbarao C, Subbarao CV, De-Deus G, Zehnder M. The impact of root dentine conditioning on sealing ability and push-out bond strength of an epoxy resin root canal sealer. Int Endod J. 2011;44(6):491-498.
  • 26. Vilanova WV, Carvalho-Junior JR, Alfredo E, Sousa-Neto MD, Silva-Sousa YT. Effect of intracanal irrigants on the bond strength of epoxy resin-based and methacrylate resin-based sealers to root canal walls. Int Endod J. 2012;45(1):42-48.
  • 27. Ballal NV, Tweeny A, Khechen K, Prabhu KN, Satyanarayan, Tay FR. Wettability of root canal sealers on intraradicular dentine treated with different irrigating solutions. J Dent. 2013;41(6):556-560.
  • 28. Hashem AA, Ghoneim AG, Lutfy RA, Fouda MY. The effect of different irrigating solutions on bond strength of two root canal-filling systems. J Endod. 2009;35(4):537-540.
  • 29. Aranda-Garcia AJ, Kuga MC, Vitorino KR, et al. Effect of the root canal final rinse protocols on the debris and smear layer removal and on the push-out strength of an epoxy-based sealer. Microsc Res Tech. 2013;76(5):533-537.
  • 30. Nagas E, Uyanik MO, Eymirli A, et al. Dentin moisture conditions affect the adhesion of root canal sealers. J Endod. 2012;38(2):240-244.
  • 31. Skidmore LJ, Berzins DW, Bahcall JK. An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha. J Endod. 2006;32(10):963-966.
  • 32. Orstavik D, Eriksen HM, Beyer-Olsen EM. Adhesive properties and leakage of root canal sealers in vitro. Int Endod J. 1983;16(2):59-63.
  • 33. Stewart GG. A comparative study of three root canal sealing agents. Oral Surg Oral Med Oral Pathol. 1958;11(9):1029-1041.
  • 34. Goracci C, Tavares AU, Fabianelli A, Monticelli F, Raffaelli O, Cardoso PC, et al. The adhesion between fiber posts and root canal walls: comparison between microtensile and push-out bond strength measurements. Eur J Oral Sci. 2004;112(4):353-361.
  • 35. Drummond JL, Sakaguchi RL, Racean DC, Wozny J, Steinberg AD. Testing mode and surface treatment effects on dentin bonding. J Biomed Mater Res. 1996;32(4):533-541.
  • 36. Erickson RL. Surface interactions of dentin adhesive materials. Oper Dent. 1992;(Suppl 5):81-94.
  • 37. Topçuoğlu HS, Tuncay Ö, Demirbuga S, Dinçer AN, Arslan H. The effect of different final irrigant activation techniques on the bond strength of an epoxy resin-based endodontic sealer: a preliminary study. J Endod. 2014;40(6):862-866.
  • 38. Fisher MA, Berzins DW, Bahcall JK. An in vitro comparison of bond strength of various obturation materials to root canal dentin using a push-out test design. J Endod. 2007;33(7):856-858.
  • 39. Patil SA, Dodwad PK, Patil AA. An in vitro comparison of bond strengths of Gutta-percha/AH Plus, Resilon/Epiphany self-etch and EndoREZ obturation system to intraradicular dentin using a push-out test design. J Conserv Dent. 2013;16(3):238-242.
  • 40. Uzunoğlu Özyürek E, Aktemur Türker S, Karahan S. Influence of Different final root canal irrigation regimens on the push-out bond strength of AH Plus. J Dent Fac Atatürk Uni. 2015;25(3):306-310.
  • 41. Saleh IM, Ruyter IE, Haapasalo M, Ørstavik D. The effects of dentine pretreatment on the adhesion of root-canal sealers. Int Endod J. 2002;35(10):859-866.
  • 42. Dogan Buzoglu H, Calt S, Gümüsderelioglu M. Evaluation of the surface free energy on root canal dentine walls treated with chelating agents and NaOCl. Int Endod J. 2007;40(1):18-24.
  • 43. Giardino L, Ambu E, Becce C, Rimondini L, Morra M. Surface tension comparison of four common root canal irrigants and two new irrigants containing antibiotic. J Endod. 2006;32(11):1091-1093.
  • 44. Cruz-Filho AM, Sousa-Neto MD, Saquy PC, Pécora JD. Evaluation of the effect of EDTAC, CDTA, and EGTA on radicular dentin microhardness. J Endod. 2001;27(3):183-184.
  • 45. Carrilho MR, Carvalho RM, de Goes MF, et al. Chlorhexidine preserves dentin bond in vitro. J Dent Res. 2007;86(1):90-94.
  • 46. Nassar M, Awawdeh L, Jamleh A, Sadr A, Tagami J. Adhesion of Epiphany self-etch sealer to dentin treated with intracanal irrigating solutions. J Endod. 2011;37(2):228-230.
  • 47. Yanai R, Ueda K, Nishida T, Toyohara M, Mori O. Effects of tonicity-adjusting and surfactant agents on the antimicrobial activity of alexidine. Eye Contact Lens. 2011;37(2):57-60.
  • 48. Weis MV, Parashos P, Messer HH. Effect of obturation technique on sealer cement thickness and dentinal tubule penetration. Int Endod J. 2004;37(10):653-663.
  • 49. Marending M, Luder HU, Brunner TJ, Knecht S, Stark WJ, Zehnder M. Effect of sodium hypochlorite on human root dentine--mechanical, chemical and structural evaluation. Int Endod J. 2007;40(10):786-793.
  • 50. Lee KW, Williams MC, Camps JJ, Pashley DH. Adhesion of endodontic sealers to dentin and gutta-percha. J Endod. 2002;28(10):684-688.
Year 2022, Volume: 32 Issue: 1, 53 - 57, 15.02.2022
https://doi.org/10.17567/ataunidfd.995849

Abstract

References

  • 1. Hülsmann M, Peters OA, Dummer PM. Mechanical preparation of root canals: shaping goals, techniques and means. Endod Topics. 2005;10(1):30-76.
  • 2. Torabinejad M, Handysides R, Khademi AA, Bakland LK. Clinical implications of the smear layer in endodontics: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):658-666.
  • 3. Kandaswamy D, Venkateshbabu N. Root canal irrigants. J Conservative Dent. 2010;13(4):256.
  • 4. Basrani BR, Manek S, Sodhi RN, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod. 2007;33(8):966-969.
  • 5. Chhabra R, Huff J, Haseman J, Elwell M, Peters A. Carcinogenicity of p-chloroaniline in rats and mice. Food Chemical Toxicol. 1991;29(2):119-124.
  • 6. Stojicic S, Shen Y, Qian W, Johnson B, Haapasalo M. Antibacterial and smear layer removal ability of a novel irrigant, QMiX. Int Endod J. 2012;45(4):363-371.
  • 7. Barrios R, Ferrer-Luque CM, Arias-Moliz MT, Ruiz-Linares M, Bravo M, Baca P. Antimicrobial substantivity of alexidine and chlorhexidine in dentin. J Endod. 2013;39(11):1413-145.
  • 8. Kasikci E, Aydemir E, Yogurtcu BM, Sahin F, Bayrak OF. Repurposing of Alexidine Dihydrochloride as an Apoptosis Initiator and Cell Cycle Inhibitor in Human Pancreatic Cancer. Anticancer Agents Med Chem. 2020;20(16):1956-1965.
  • 9. Wang C, Niederstrasser H, Douglas PM, et al. Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan. Nat Commun. 2017;8(1):2270.
  • 10. da Silva TM, Alves FR, Lutterbach MT, Paiva MM, Ferreira DC. Comparison of antibacterial activity of alexidine alone or as a final ir56rigant with sodium hypochlorite and chlorhexidine. BDJ Open. 2018;4:18003.
  • 11. Jain K, Agarwal P, Jain S, Seal M, Adlakha T. Alexidine versus chlorhexidine for endodontic irrigation with sodium hypochlorite. Eur J Dent. 2018;12(3):398-402.
  • 12. Akisue E, Tomita VS, Gavini G, Poli de Figueiredo JA. Effect of the combination of sodium hypochlorite and chlorhexidine on dentinal permeability and scanning electron microscopy precipitate observation. J Endod. 2010;36(5):847-850.
  • 13. Czopik B, Ciechomska M, Zarzecka J, Góra M, Woźniakiewicz M. Insight into the Reaction of Alexidine with Sodium Hypochlorite: A Potential Error in Endodontic Treatment. Molecules. 2021;26(6):1623.
  • 14. Varadan P, Ganesh A, Konindala R, Nagendrababu V, Ashok R, Deivanayagam K. Comparison of the Antibacterial Efficacy of Alexidine and Chlorhexidine Against Enterococcus Faecalis: An in Vitro Study. Cureus. 2017;9(10):e1805.
  • 15. Zorko M, Jerala R. Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics. J Antimicrobial Chemotherapy. 2008;62(4):730-737.
  • 16. Jagtap P, Mishra R, Khanna S, et al. Mechanistic Evaluation of Lipopolysaccharide-Alexidine Interaction Using Spectroscopic and in Silico Approaches. ACS Infect Dis. 2018;4(11):1546-1552.
  • 17. Surender LR, Shikha A, Swathi A, Manaswini C, Habeeb A, Prabha SS. Alexidine: a Safer and an Effective Root Canal Irrigant than Chlorhexidine. J Clin Diagn Res. 2017;11(7):Zc18-zc21.
  • 18. Silveira LF, Baca P, Arias-Moliz MT, Rodríguez-Archilla A, Ferrer-Luque CM. Antimicrobial activity of alexidine alone and associated with N-acetylcysteine against Enterococcus faecalis biofilm. Int J Oral Sci. 2013;5(3):146-149.
  • 19. Kim HS, Zhu Q, Baek SH, et al. Chemical interaction of alexidine and sodium hypochlorite. J Endod. 2012;38(1):112-116.
  • 20. Thomas AR, Mani R, Reddy TV, Ravichandran A, Sivakumar M, Krishnakumar S. Evaluation of the Antibacterial Efficiency of a Combination of 1% Alexidine and Sodium Hypochlorite on Enterococcus faecalis Biofilm Models: An In Vitro Study. J Contemp Dent Pract. 2019;20(9):1090-1094.
  • 21. Mamouei Z, Alqarihi A, Singh S, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018;3(5):e00539.
  • 22. Sharp G, Green S, Rose M. Chlorhexidine-induced anaphylaxis in surgical patients: a review of the literature. ANZ J Surg. 2016;86(4):237-243.
  • 23. Alizadeh H, Neelam S, Cavanagh HD. Amoebicidal activities of alexidine against 3 pathogenic strains of acanthamoeba. Eye Contact Lens. 2009;35(1):1-5.
  • 24. Kermeoglu F, Aksoy U, Kalender A, Oztan MD, Oguz EI, Kıyan M. Determination of the Minimum Inhibitory Concentrations of Alexidine and Chlorhexidine Against Enterococcus faecalis and Candida albicans: An In Vitro Study. Cureus. 2018;10(2):e2221.
  • 25. Neelakantan P, Subbarao C, Subbarao CV, De-Deus G, Zehnder M. The impact of root dentine conditioning on sealing ability and push-out bond strength of an epoxy resin root canal sealer. Int Endod J. 2011;44(6):491-498.
  • 26. Vilanova WV, Carvalho-Junior JR, Alfredo E, Sousa-Neto MD, Silva-Sousa YT. Effect of intracanal irrigants on the bond strength of epoxy resin-based and methacrylate resin-based sealers to root canal walls. Int Endod J. 2012;45(1):42-48.
  • 27. Ballal NV, Tweeny A, Khechen K, Prabhu KN, Satyanarayan, Tay FR. Wettability of root canal sealers on intraradicular dentine treated with different irrigating solutions. J Dent. 2013;41(6):556-560.
  • 28. Hashem AA, Ghoneim AG, Lutfy RA, Fouda MY. The effect of different irrigating solutions on bond strength of two root canal-filling systems. J Endod. 2009;35(4):537-540.
  • 29. Aranda-Garcia AJ, Kuga MC, Vitorino KR, et al. Effect of the root canal final rinse protocols on the debris and smear layer removal and on the push-out strength of an epoxy-based sealer. Microsc Res Tech. 2013;76(5):533-537.
  • 30. Nagas E, Uyanik MO, Eymirli A, et al. Dentin moisture conditions affect the adhesion of root canal sealers. J Endod. 2012;38(2):240-244.
  • 31. Skidmore LJ, Berzins DW, Bahcall JK. An in vitro comparison of the intraradicular dentin bond strength of Resilon and gutta-percha. J Endod. 2006;32(10):963-966.
  • 32. Orstavik D, Eriksen HM, Beyer-Olsen EM. Adhesive properties and leakage of root canal sealers in vitro. Int Endod J. 1983;16(2):59-63.
  • 33. Stewart GG. A comparative study of three root canal sealing agents. Oral Surg Oral Med Oral Pathol. 1958;11(9):1029-1041.
  • 34. Goracci C, Tavares AU, Fabianelli A, Monticelli F, Raffaelli O, Cardoso PC, et al. The adhesion between fiber posts and root canal walls: comparison between microtensile and push-out bond strength measurements. Eur J Oral Sci. 2004;112(4):353-361.
  • 35. Drummond JL, Sakaguchi RL, Racean DC, Wozny J, Steinberg AD. Testing mode and surface treatment effects on dentin bonding. J Biomed Mater Res. 1996;32(4):533-541.
  • 36. Erickson RL. Surface interactions of dentin adhesive materials. Oper Dent. 1992;(Suppl 5):81-94.
  • 37. Topçuoğlu HS, Tuncay Ö, Demirbuga S, Dinçer AN, Arslan H. The effect of different final irrigant activation techniques on the bond strength of an epoxy resin-based endodontic sealer: a preliminary study. J Endod. 2014;40(6):862-866.
  • 38. Fisher MA, Berzins DW, Bahcall JK. An in vitro comparison of bond strength of various obturation materials to root canal dentin using a push-out test design. J Endod. 2007;33(7):856-858.
  • 39. Patil SA, Dodwad PK, Patil AA. An in vitro comparison of bond strengths of Gutta-percha/AH Plus, Resilon/Epiphany self-etch and EndoREZ obturation system to intraradicular dentin using a push-out test design. J Conserv Dent. 2013;16(3):238-242.
  • 40. Uzunoğlu Özyürek E, Aktemur Türker S, Karahan S. Influence of Different final root canal irrigation regimens on the push-out bond strength of AH Plus. J Dent Fac Atatürk Uni. 2015;25(3):306-310.
  • 41. Saleh IM, Ruyter IE, Haapasalo M, Ørstavik D. The effects of dentine pretreatment on the adhesion of root-canal sealers. Int Endod J. 2002;35(10):859-866.
  • 42. Dogan Buzoglu H, Calt S, Gümüsderelioglu M. Evaluation of the surface free energy on root canal dentine walls treated with chelating agents and NaOCl. Int Endod J. 2007;40(1):18-24.
  • 43. Giardino L, Ambu E, Becce C, Rimondini L, Morra M. Surface tension comparison of four common root canal irrigants and two new irrigants containing antibiotic. J Endod. 2006;32(11):1091-1093.
  • 44. Cruz-Filho AM, Sousa-Neto MD, Saquy PC, Pécora JD. Evaluation of the effect of EDTAC, CDTA, and EGTA on radicular dentin microhardness. J Endod. 2001;27(3):183-184.
  • 45. Carrilho MR, Carvalho RM, de Goes MF, et al. Chlorhexidine preserves dentin bond in vitro. J Dent Res. 2007;86(1):90-94.
  • 46. Nassar M, Awawdeh L, Jamleh A, Sadr A, Tagami J. Adhesion of Epiphany self-etch sealer to dentin treated with intracanal irrigating solutions. J Endod. 2011;37(2):228-230.
  • 47. Yanai R, Ueda K, Nishida T, Toyohara M, Mori O. Effects of tonicity-adjusting and surfactant agents on the antimicrobial activity of alexidine. Eye Contact Lens. 2011;37(2):57-60.
  • 48. Weis MV, Parashos P, Messer HH. Effect of obturation technique on sealer cement thickness and dentinal tubule penetration. Int Endod J. 2004;37(10):653-663.
  • 49. Marending M, Luder HU, Brunner TJ, Knecht S, Stark WJ, Zehnder M. Effect of sodium hypochlorite on human root dentine--mechanical, chemical and structural evaluation. Int Endod J. 2007;40(10):786-793.
  • 50. Lee KW, Williams MC, Camps JJ, Pashley DH. Adhesion of endodontic sealers to dentin and gutta-percha. J Endod. 2002;28(10):684-688.
There are 50 citations in total.

Details

Primary Language English
Subjects Dentistry
Journal Section Research Articles
Authors

Emine Odabaşı Tezer This is me 0000-0003-3669-5062

Meltem Dartar Öztan This is me 0000-0002-1693-0355

Publication Date February 15, 2022
Submission Date March 2, 2021
Published in Issue Year 2022 Volume: 32 Issue: 1

Cite

AMA Odabaşı Tezer E, Dartar Öztan M. EFFECT OF ALEXIDINE DIHYDROCHLORIDE ON THE BOND STRENGTH OF RESIN-BASED SEALER TO DENTIN. Curr Res Dent Sci. February 2022;32(1):53-57. doi:10.17567/ataunidfd.995849

Current Research in Dental Sciences is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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