Tip 2 Diyabet Riski ve Hastalık Sürecinde Uykunun Rolü

Year 2015, Volume: 8 Issue: 3, 203 - 208, 01.08.2015

Deniz Talaz Sevgi Kızılcı

Abstract

Uyku bozuklukları, günümüzde çocuklarda ve erişkinlerde yaygın bir sorundur. Bu derlemede, uyku bozukluklarının metabolik sonuçlar ve beslenme davranışıyla ilişkisi ile diyabetin uykuya etkisi özetlenecektir. Uyku bozukluklarında büyüme hormonu salınımında azalma, sempatik aktivite ve kortizol düzeyinde artış nedeniyle metabolik sonuçlarda bozulma görülürken, leptin ve ghrelin salınımlarında değişim sonucu gıda alımında artma olmaktadır. Bu değişimler, kilo alma, obezite, bozulmuş glukoz toleransı, insülin direnci ve tip 2 diyabet riskini arttırmaktadır. Diyabetli bireylerde, diyabet komplikasyonları da uyku bozukluklarına yol açabilmektedir. Bu nedenle, diyabetli bireylerde kan glukozu kontrolü için dikkate alınan mevcut yaklaşımlarla birlikte uyku kalitesinin geliştirilmesi önemlidir.

Keywords

Uyku, Uyku bozuklukları, Diyabet, Glisemik Kontrol

Role of Sleep in The Risk and Severity of Type 2 Diabetes

Abstract

Nowadays, sleep disorders are common problems among the children and adults. In this article, the relationship between
metabolic consequences and eating behaviour and sleep disorders, and the effect of diabetes on sleep will be summarized. In
sleep disorders, while deterioration in the matabolic consequences are observed as a result of the increase of sympathetic
activity, cortisol levels, and the decrease of growth hormone, there is an increase in the food intake resulting from the change
in leptin and ghrelin secretions. These changes increase the risk of weight gain, obesity, impaired glucose tolerance, insulin
resistance and type 2 diabetes. In the other hand, the complications of diabetes may contribute to sleep disorders. In addition to
the current approach for controlling glucose level in blood, improving the sleep quality of individulas with diabetes is also
important.

Keywords

Sleep, Sleep disorders, Diabetes, Glycemic control.

References

• American Diabetes Association. (2014). Standards of medical care in diabetes-2014. Diabetes Care, 37(1), 14-80
• Ardic, S., Demir, A. U., Ucar, Z. Z., Fırat, H., Itıl, O., Karadeniz, D., et al. (2013). Prevalence and associated factors of sleep-disordered breathing in the Turkish adult population. Sleep and Biological Rhythms, 11, 29-39.
• Bendtson, I., Gade, J., Theilgaard, A., & Binder C. (1992). Cognitive function in type 1 (insulin dependent) diabetic patients after nocturnal hypoglycaemia. Diabetologia, 35, 898–903.
• Bendtson, I., Kverneland, A., Pramming, S., & Binder, C. (1988). Incidence of nocturnal hypoglycaemia in insulin- dependent diabetic patients on intensive therapy. Acta Med Scand, 223, 543–8.
• Bonnet, M. H., & Arand, D. L. (1995). We are chronically sleep deprived. Sleep, 18, 908-11.
• Bora, İ. H., & Bircan, A. (2007). Uyku fizyolojisi. Türkiye Klinikleri J Surg Med Sci, 3(23): 1-6.
• Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The pittsburgh sleep quality index: a new instrument for psychiatric practice and research. Psychiatry Res, 28(2): 193-21.
• Ceddia, R. B., William, W. N., & Curi, R. (1999). Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: Evidence for an effect of leptin on glucose uptake and decarboxylation. Int J Obes Relat Metab Disord, 23(1): 75-82.
• Chong, M. S., & Hester, J. (2007). Diabetic painful neuropathy: current and future treatment options. Drugs, 67(4), 569-85.
• Copinschi, G. (2005). Metabolic and endocrine effects of sleep deprivation. Essent Psychopharmacol, 6(6): 341-7.
• Copinschi, G., Leproult, R., & Spiegel, K. (2014). The important role of sleep in metabolism. Front Horm Res., 42: 59-72.
• Cummings, D. E., & Foster, K. E. (2003). Ghrelin–leptin tango in body-weight regulation. Gastroenterology, 124(5): 1532−5.
• Davies, S. K., Ang, J. E., Revell, V. L., Holmes, B., Mann, A., Robertson, F. P., et al. (2014).
• Effect of sleep deprivation on the human metabolome. Proc Natl Acad Sci U S A., 22; 111(29): 10761-6.
• Depner, C. M., Stothard, E.R., & Wright, K. P. Jr. (2014). Metabolic consequences of sleep and circadian disorders. Curr Diab Rep., 14(7): 507.
• Dzaja, A., Arber, S., Hislop, J., Kerkhofs, M., Kopp, C., Pollmächer, T., et al. (2005). Women’s sleep in health and disease. J Psychiatr Res, 39: 55–76.
• Ertuğrul, A., & Rezaki, M. (2004). Uyku nörolojisi ve bellek üzerine etkileri. Türk Psikiyatri Dergisi, 15: 300-308. Friess, E., Wiedemann, K., Steiger, A., & Holsboer, F. (1995). The hypothalamic–pituitary adrenocortical system and sleep in man. Adv Neuroimmunol, 5(2): 111−25.
• Gale, E. A. M., & Tatersall, R. B. (1979). Unrecognised nocturnal hypogly-caemia in insulin treated diabetics. Lancet. İ, 1049–52.
• Gale, S. M., Castracane, V. D., & Mantzoros, C. S. (2004). Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. Journal of Nutrition, 134: 295–8.
• Gangwisch, J. E. (2009). Epidemiological evidence for the links between sleep, circadian rhythms and metabolism. Obesity reviews, 10(2), 37–45.
• Henderson, V. (1966). The nature of nursing. New York: The Macmillan Company.
• Hernandez, A., Philippe, J., & Jornayvaz, F. R. (2012). Sleep and diabetes. Rev Med Suisse, 8(344): 1198-200, 1202-3.
• Hood, M. M., Reutrakul, S., & Crowley, S. J. (2014). Night eating in patients with type 2 diabetes. Associations with glycemic control, eating patterns, sleep, and mood. Appetite, 79, 91-96.
• International Diabetes Federation. (2013). IDF diabetes atlas, (6th edn). Brussels, Belgium: International Diabetes Federation. Erişim: 19.04.2015. http://www.idf.org/diabetesatlas.
• Irwin, M., Thompson, J., Miller, C., Gillin, J. C., & Ziegler, M. (1999). Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: Clinical implications. The Journal of Clinical Endocrinology and Metabolism, 84(6), 1979-85.
• Janeckova, R. (2001). The role of leptin in human physiology and pathophysiology. Physiol Res, 50: 443-459.
• Kessler, L., Nedeltcheva, A., Imperial, J., & Penev, P. D. (2010). Changes in serum tsh and free T4 during human sleep restriction. Sleep, 33(8), 1115-8. Kline, C. E., Irish, L. A., Krafty, R. T., Sternfeld, B., Kravitz, H. M., Buysse, D. J., et al. (2013).
• Consistently high sports/exercise activity is associated with better sleep quality, continuity and depth in mildlife women: the SWAN Sleep Study, 36(9), 1279-1288.
• Knutson, K. L. (2007). Impact of sleep and sleep loss on glucose homeostasis and appetite. Sleep Med Clin, 2(2), 187-97.
• Koban, M., & Swinson, K. L. (2005). Chronic rem-sleep deprivation of rats elevates metabolic rate and increases ucp1 gene expression in brown adipose tissue. Am J Physiol Endocrinol Metab, 289: 68-74. 3.
• Kurose, T., Hyo, T., Yabe, D., & Seino, Y. (2014). The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes. ChronoPhysiology and Therapy, 4, 41–49.
• Lane, T., & East, L. A. (2008). Sleep disruption experienced by surgical patients in an acute hospital. British Journal of Nursing, 17, 766–71.
• Lim, L.L. & Foldvary-Schaefer, N. (2010). Sleep disorders. In: Tavee J, (Ed.), Cleveland clinic: Current clinical medicine (2.th ed. pp. 914-915). Philadelphia: Elsevier Health Sciences.
• Miro, E., Cano, M. C., Espinozo-Fernandez, L., & BuelaCasal, G. (2003). Time estimation during prolonged sleep deprivation and its relation to activation measures. J Human Factors and Ergonomics Society, 45: 148-159.
• Moraes, D. A., Venancio, D. P., & Suchecki, D. (2014). Sleep deprivation alters energy homeostasis through non-compensatory alterations in hypothalamic insulin receptors in Wistar rats. Hormones and Behavior, 66:705–712.
• Morselli, L., Leproult, R., Balbo, M., & Spiegel, K. (2010). Role of sleep duration in the regulation of glucose metabolism and appetite. Best Pract Res Clin Endocrinol Metab, 24(5), 687–702.
• Nedeltcheva, A. V., & Scheer, F. A. J. L. (2014). Metabolic effects of sleep disruption, links to