Biyomedikal Uygulamalar için Wollastonit Partikül Takviyeli Hidroksiapatit Kompozit Granüllerin Üretilmesi ve Karakterizasyonu

Abstract

Hidroksiapatit (HA) kemik ve dişin temel inorganik bileşenidir ve yüksek biyoaktiviteye, biyouyumluluğa ve kemik bütünleşim kabiliyetine sahiptir. Son zamanlarda, biyouyumluluk ve mekanik mukavemetini ileriye taşıyabilmek için HA yapısına wollastonitin (WT) takviye edilmesi önerilmektedir. Bu çalışmanın odak noktası, püskürtme kurutma ile HA/WT kompozit granüllerin üretilmesi ve karakterize edilmesidir. Ticari WT partikülleri, laboratuvar ortamında hazırlanan HA nanopartiküllerine katılarak, püskürtme kurutma çamuru hazırlanmıştır. Püskürtme kurutulan HA/WT granüllerinin (SD-HA/WT) termo-fiziksel özellikleri SEM, FTIR, granül boyut ölçümü, TG-DTA ve XRD analizleriyle incelenmiştir. Analizler, kompozit granüllerin HA ve WT fazlarından oluştuğunu ortaya koymuştur. Granüller, matrisi oluşturan HA nanopartiküllerden ve HA matris içerisine ve yüzeye karışmış WT partiküllerden oluşmuştur. 750 °C’de yapılan ısıl işlem, sentezlenen HA nanopartiküllerin kalsinasyonuna neden olurken, 1000 °C ve 1250 °C’de yapılan ısıl işlemler sayesinde HA nanopartikülleri sinterlenmiştir, dolayısıyla granüllerin mekanik özellikleri artmıştır. Granüllerin faz yapıları ısıl işlemden sonra stabil kalmıştır (baskın olarak kristalin HA ve WT). Bununla birlikte, WT takviyesi HA’nın dehidroksilasyon sıcaklığının düşmesine neden olmuştur ve 1000 °C’de yapılan ısıl işlemden sonra diğer kalsiyum fosfat fazları oluşmuştur. Rietveld Refinement analizi, granüllerin sırasıyla %82,3 ve %15,6 HA ve WT fazına sahip olduğunu ortaya çıkarmıştır. 36 μm medyan boyutuna (d50) sahip olan küresel granüller termal sprey, 3b yazıcı ve sıcak presleme prosesinde kullanılabilir.

Keywords

• Biyoseramikler
• Püskürtme Kurutma
• Kompozit
• Hidroksiapatit
• Wollastonit

Production and Characterization of Wollastonite Particles Reinforced Hydroxyapatite Composite Granules for Biomedical Applications

Abstract

Hydroxyapatite (HA) is the main inorganic component of bone and teeth and having high bioactivity, biocompatibility and osteointegration capability. Recently, wollastonite (WT) has been offered to reinforce HA to further increase biocompatibility and also mechanical strength. The focus of this study was to produce and characterize HA/WT composite granules with spray drying. Commercial WT particles were introduced into the lab made HA nanoparticles in order to prepare a slurry for spray drying. Spray dried HA/WT granules (SD-HA/WT) were investigated in terms of thermo-physical properties by SEM, FTIR, granule size analyzer, TG-DTA and XRD. The investigations proved that composite granules were comprised both HA and WT phases. The granules contained HA nanoparticles (as a matrix) and WT particles that entangled in the HA matrix and on the surface of the granules. The heat treatment at 750 °C led to the calcination of synthesized HA nanoparticles, while, the nanoparticles were sintered together by the heat treatment at 1000 °C and 1250 °C, thus the mechanical integrity of the granules was developed. The phase structure of the granules was remained stable (dominantly crystalline HA and WT) after the heat treatments. However, WT reinforcement caused to decrease the dehydroxylation temperature of HA and other calcium phosphates were formed after the heat treatment at 1000 °C. Rietveld Refinement analysis revealed that composite granules had 82.3% and 15.6% HA and WT phases, respectively. Spherical shaped granules with 36 µm median size (d50) would be used in thermal spraying, 3d printing or hot-pressing processes.

Keywords

• Bioceramics
• Spray drying
• Composite
• Hydroxyapatite
• Wollastonite

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