Synthesis and Characterization of New Series Benzothiazole-Dithiocarbamate Derivatives As Potential Antifungal Agents

Abstract

Invasive fungal infections (IFIs) have been and will continue to be a great threat to human. Nowadays the aim of many medical research is to discover new safer and more effective antifungal agents. Benzothiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities. Furthermore, dithiocarbamate compounds have become important for many activities due to their chemical structure. In this study, it was aimed to determine being antifungal agents capacity of newly synthesized benzothiazole compounds including dithiocarbamate moiety. The structures of the obtained compounds were elucidated using by 1H-NMR, 13C-NMR and mass spectroscopy.

Keywords

• Benzothiazole
• Dithiocarbamate
• NMR
• Antifungal activity

Potansiyel Antifungal Ajanlar Olarak Yeni Benzotiyazol-Ditiyokarbamat Türevlerinin Sentezi ve Karakterizasyonu

Abstract

İnvaziv mantar enfeksiyonları (IFI'lar) insan için büyük bir tehdit olmuştur ve olmaya devam edecektir. Günümüzde birçok tıbbi araştırmanın amacı yeni daha güvenli ve daha etkili antifungal ajanlar bulmaktır. Benzotiyazol bileşikleri, çok çeşitli biyolojik aktiviteleri nedeniyle farmasötik kimyada önemli bir farmakofor yapıdır. Ayrıca, ditiyokarbamat bileşikleri kimyasal yapıları nedeniyle birçok aktivite için önemli hale gelmiştir. Bu çalışmada, yeni sentezlenen benzotiyazol-ditiyokarbamat bileşiklerinin antifungal etkinliklerinin belirlenmesi amaçlanmıştır. Elde edilen bileşiklerin yapıları, 1H-NMR, 13C-NMR ve kütle spektroskopisi kullanılarak aydınlatılmıştır.

Keywords

• Benzotiyazol
• Ditiyokarbamat
• NMR
• Antifungal aktivite

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