İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini

Year 2019, Volume: 21 Issue: 61, 185 - 194, 15.01.2019

Güzide Pekcan Ertokuş , Ayşe Merve Akkaya Ziya Mermertaş Reciye Kurşunlu

Abstract

Bu çalışmada,  tablet ilaç numunesinde bulunan parasetamol,
asetilsalisilik asit ve kafein etken maddelerinin ultraviyole
spektrofotometrisi yöntemi ile elde edilen sonuçlarının kemometrik metotlarla
birlikte değerlendirilmesi ile tayini gerçekleştirilmiştir. Deneysel çalışmada
maddelerin tek tek saf haldeki spektrumları elde edildikten sonra her bir ilaç
etken maddesinden alınarak sentetik karışım hazırlanmıştır. Bir sonraki aşamada
tablet numunesi analizi yapılmıştır. Kemometrik yöntemlerden, temel bileşen
regresyonu yöntemi (PCR) ve kısmi en küçük kareler yöntemi (PLS), sentetik
karışım ve tablet numunesindeki miktar tayininde başarı ile uygulanmıştır. Elde
edilen veriler, istatistik olarak incelendiklerinde hem hesaplanan geri kazanım
değerleri yüksek hem de standart sapmalar yeterince küçüktür. Ayrıca yöntemin
uygunluğu açısından F-testi uygulanmış ve sonuçlar uyumlu bulunmuştur.
Uygulanan kemometrik yöntemler yardımıyla elde edilen sonuçlar son derece
hızlı, basit ve güvenilir sonuçlardır.

Keywords

Asetilsalisilik asit, Parasetamol, Kafein, Kemometri

Determination of Acetylsalicylic Acid, Paracetamol and Caffeine in Drug Formulation with Chemometric Methods

Abstract

In this study, the results of
ultraviolet spectrophotometry of paracetamol, acetylsalicylic acid and caffeine
active substances in tablet drug sample were evaluated together with
chemometric methods. In the experimental study, the synthetic mixtures were
prepared by taking each drug from the active ingredient after obtaining the
individual pure spectra of the substances. At the next stage, a tablet sample
analysis was performed. From the chemometric methods, the principle component
regression method (PCR) and the partial least squares method (PLS) have been
successfully applied in the quantification of the synthetic mixtures and the
tablet sample. When the data obtained are statistically analyzed, both the
calculated recovery values ​​are high and the standard deviations are small
enough. In addition, F-test was applied in terms of the suitability of the
method and the results were found to be compatible. The results obtained with
the help of applied chemometric methods are very fast, simple and reliable
results.

Keywords

Acetylsalicylic acid, Paracetamol, Cafffeine, Chemometry

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