Adverse Reactions To Blue Dye Injections During Sentinel Lymph Node Biopsy

Öz

Objective: Sentinel lymph node biopsy for breast cancer surgical treatment has been used as an alternative of axillary dissection in most cases. The aim of our study is to report the rate of adverse reactions during sentinel lymph node biopsies in early stage (T1-T2, N0, M0) breast cancer patients.

Material and method: We retrospectively reviewed 1374 consecutive SLNBs patients for early stage breast cancer between May 1998 and April 2017 in our clinic.

Results: Blue dye was used in SLN biopsies in 315 patients. An allergic reaction occurred in 12 of these patients (0.4%). The patients' stay in the hospital did not change and they received adjuvant treatment without delay.

Conclusion: Sentinel lymph node biopsy can be performed using only radioactive colloid injection to protect against the allergic reactions caused by the blue dye. Deep parenchymal injections may be preferred instead of intradermal injections due to toxic effects on the tissue in cases where blue dye should be applied.

Anahtar Kelimeler

• Sentinel lymph node,blue dye,side effect

Sentinel lenf nodu örneklemesi esnasında uygulanan boya sonucunda görülen yan etkiler

Öz

Amaç: Sentinel lenf nodu biyopsisi pek çok meme kanserli hastanın cerrahi tedavisi için aksiller lenf nodu diseksiyonuna alternatif olarak uygulanabilir. Çalışmamızın amacı, erken evre (T1-T2, N0, M0 ) meme kanserli hastalarda radyokolloid enjeksiyonu ile kombine veya tek başına mavi boya kullanılarak yapılan sentinel lenf nodu biyopsilerinde karşılaştığımız yan etkileri bildirmektir.

Gereç ve yöntem: Kliniğimizde erken evre meme kanseri nedeni ile Mayıs 1998 - Nisan 2017 tarihleri arasında yapılmış 1374 adet sentinel lenf nodu biyopsisi sonuçları retrospektif olarak incelendi.

Bulgular: Sentinel lenf nodu biyopsisi yapılan hastalardan 315 tanesinde boya kullanıldı. Bu hastaların 12 tanesinde (%0,4) alerjik reaksiyon görüldü. Hastaların hastanede kalış sürelerinde değişiklik olmadı ve adjuvan tedavilerini gecikme olmaksızın aldılar.

Sonuç: Mavi boyanın yol açtığı alerjik reaksiyonlardan korunmak için sadece radyoizotop ile işlem yapılabilir. Mavi boya uygulanması gereken olgularda ise doku üzerindeki toksik etkilerinden ötürü intradermal enjeksiyonlar yerine derin parankimal enjeksiyonlar tercih edilebilir.

Anahtar Kelimeler

• Sentinel lenf nodu,mavi boya,yan etki

Kaynakça

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