Do uterine fibroids which are left to postmenopausa have any negative effects on the developing endometrial cancer?

Year 2018, Volume: 32 Issue: 1, 9 - 14, 18.05.2018

Hamdullah Pekkolay Önder Sakin Zehra Meltem Pirimoğlu Gülhan Bayraktar

https://doi.org/10.5505/deutfd.2018.88700

Abstract

Objective: Endometrial cancer and uterine
leiomyoma are the most common malignant and benign tumors in developed
countries. In women operated for endometrial cancer, accompanying uterine myome
is observed in high rates. The treatment of the premenopausal myomas is delayed
after the menopause conservatively.

Yet it is unclear whether this approach has any
negative effect on possible endometrial cancer. The goal of this study is to
investigate the relationship between premenopausal myomas and the prognostic
factors of endometrial cancer.

Material and Method: The files of 127 patients who were operated between
January 2005 and February 2011 in our hospital fulfilling the criteria were
investigated retrospectively. Sociodemographic characteristics, obstetric
traits, myoma presence, endometrial tumor presence, tumor grade, myometrial
invasion grade were evaluated and significance was investigated.

Results: Factors affecting the prognosis of endometrial
carcinoma; age, histological type, histological grade and myometrial invasion were
found to be not significantly related to myoma uteri.

Conclusion: Endometrial cancer, the most common gynecologic cancer
in women, and uterine myoma, the most common benign tumor, were investigated
together. The histopathological prognostic findings of endometrial cancer are
unchanged by the presence uterine myoma. Therefore we reached the conclusion
that there is no negative impact on prognosis.

Keywords

Endometrial neoplasms, myoma uteri, risk factors, postmenopause

Menopoz sonrasına bırakılan uterin myomların gelişen endometrium kanseri üzerine olumsuz etkileri var mıdır?

Abstract

Amaç: Endometrium
kanseri ve myoma uteri, gelişmiş ülkelerde en sık görülen malign ve benign
tümörlerdir. Endometrium kanseri nedeniyle opere olan kadınlarda myoma uterinin
de yüksek oranlarda eşlik ettiği görülmektedir. Premenopozal dönemde
konservatif bir yaklaşım ile, medikal tedavilerle menopoz sonrasına ertelenen
premenopozal myomların olası endometrium kanseri üzerine herhangi bir olumsuz
etkisinin bulunup bulunmadığı araştırıldı.

Gereç ve Yöntem:
Çalışmada Ocak 2005 - Şubat 2011 yılları arasında hastanemizde opere edilmiş ve
araştırma kriterlerine uyan 127 hasta dosyası retrospektif olarak incelendi.
Sosyodemografik özellikleri, obstetrik öyküleri, myom varlığı, endometrial
tümör varlığı, tümör derecesi, myometriuma invazyon derecesi değerlendirildi ve
anlamlılığı araştırıldı.

Bulgular: Endometrial
karsinom prognozuna etkili faktörlerden yaş, histolojik tip, histolojik derece
ve myometrial invazyon durumlarının myoma uteri ile ilişkisi bulunmadığı
belirlendi.

Sonuç: Kadınlarda en
sık görülen jinekolojik kanser olan endometrium kanseri ile en sık görülen
benign tümörü olan myoma uterinin beraberlikleri araştırılmış ve endometrium
kanserinin histopatolojik prognostik bulgularının myoma uteri varlığıyla
değişmediği, dolayısıyla prognoza olumsuz etkisinin olmadığı sonucuna
ulaşılmıştır.

Keywords

Endometrium kanseri, myoma uteri, risk faktörleri, postmenopoz

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