The Role of MicroRNAs and Their Importance as Novel Treatment Approaches in Cystic Fibrosis

Yıl 2019, Cilt: 33 Sayı: 2, 175 - 182, 27.09.2019

İlksen Berfin Ekinci Didem Dayangaç-erden

Öz

MicroRNAs (miRNA), which belong to non-coding RNA group, have been associated with clinical severity in autoimmune diseases, cancer, cardiovascular diseases and some respiratory diseases also many studies have been carried out on their use as therapeutic targets in recent years. In cystic fibrosis, one of the autosomal recessive inherited respiratory system diseases caused by mutations in the CFTR gene, many miRNAs associated with the pathogenesis of the disease have been identified. In this review research about the role of miRNAs in cystic fibrosis, their relationship with severity of disease, miRNA based treatment approaches and their use as prognostic and therapeutic biomarkers are summarized.

Kistik Fibrozis Hastalığında Mikro RNA’ların Rolü ve Yeni Tedavi Yaklaşımları Açısından Önemi

Öz

Kodlanmayan RNA grubunda yer alan mikroRNA’lar (miRNA) son yıllarda otoimmün hastalıklar, kanser, kardiyovasküler hastalıklar ve bazı solunum yolu hastalıklarında klinik ciddiyet ile ilişkilendirilmiştir ve tedavi hedefi olarak kullanılmalarına ilişkin birçok araştırma gerçekleştirilmiştir. CFTR genindeki mutasyonlar sonucu oluşan ve otozomal resesif kalıtılan solunum sistemi hastalıklarından birisi olan kistik fibroziste günümüze kadar hastalık patogenezi ile ilişkilendirilen çok sayıda miRNA tanımlanmıştır. Bu derlemede, kistik fibrozis hastalığında miRNA’ların rolü, hastalık ciddiyeti ile ilişkisi, miRNA temelli tedavi yaklaşımları ve ileride prognostik ve terapötik biyobelirteç olarak kullanılmalarına yönelik gerçekleştirilen araştırmalar özetlenmiştir.

Anahtar Kelimeler

Kistik fibrozis, CFTR geni, mikroRNA, biyobelirteç

Kaynakça

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