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The Relationship of Copper, Iron, Zinc Elements with Parkinson's Disease in Brain Homeostasis

Year 2022, Volume: 5 Issue: 2, 1 - 11, 31.12.2022
https://doi.org/10.57244/dfbd.1073262

Abstract

References

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  • Genoud, S., Roberts, B. R., Gunn, A. P., Halliday, G. M., Lewis, S. J. G., Ball, H. J., Hare, D. J., Double, K. L. (2017). Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain. Metallomics, 9(10), 1447-1455. doi: 10.1039/c7mt00244k.
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  • Hara, T., Takeda, T. A., Takagishi, T., Fukue, K., Kambe, T., Fukada, T. (2017). Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis. J Physiol Sci, 67(2), 283-301. doi: 10.1007/s12576-017-0521-4.
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Beyin Homeostazında Bakır, Demir, Çinko Elementlerinin Parkinson Hastalığı ile İlişkisi

Year 2022, Volume: 5 Issue: 2, 1 - 11, 31.12.2022
https://doi.org/10.57244/dfbd.1073262

Abstract

Elementler doğada farklı formlarda bulunmaktadırlar. Vücut ağırlığımızın yaklaşık %96’sını oksijen, karbon, hidrojen ve azot, %2,5’sını kalsiyum ve fosfor oluşturmaktadır. Geriye kalan yaklaşık %1,5’lik kısmı ise eser elementler (potasyum, sülfür, sodyum, magnezyum, flor, bakır, demir, çinko, manganez, kobalt, selenyum, iyot, klor, krom, molibden, lityum, stronsiyum, alüminyum, silisyum, kurşun, vanadyum, arsenik, brom) oluşturmaktadır. Eser elementler çeşitli biyolojik ve kimyasal reaksiyonlarda görev almakta ve sağlığın devamı için önem arz etmektedirler. Eser elementler hücresel fonksiyonların doğru yürütülmesi için gerekli olmalarının yanı sıra, emilim ve atılımlarında dengenin bozulması sonucu hücre için toksisite oluşturmaktadırlar. Özellikle metal eser elementlerde homeostazın bozulması canlı için yüksek toksisitede olmakta ve çeşitli hastalıklara sebebiyet vermektedir. Nörodejeneratif hastalıklardan biri olan Parkinson hastalığında, bakır ve demir elementlerinin beyin bölgelerindeki fazlalığı reaktif oksijen türleri (ROT) artışına ve beraberinde de oksidatif strese neden olmaktadır. Çinko elementi ve Parkinson hastalığı arasındaki ilişkinin anlaşılabilmesi için çalışmalar devam etmekle beraber, mevcut veriler kapsamında beyin omurilik sıvısında ve substantia nigrada çinko homeostazında bozulma olduğu bildirilmektedir. Bu sebeple henüz oluşum sebebi ve tedavisi bilinmeyen Parkinson hastalığında bu elementler ile yapılan çalışmaların aydınlatılmasının hastalığın oluşum yolaklarının aydınlatılmasına ve tedavisine katkı sağlayacağı düşünülmektedir.

References

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  • Hara, T., Takeda, T. A., Takagishi, T., Fukue, K., Kambe, T., Fukada, T. (2017). Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis. J Physiol Sci, 67(2), 283-301. doi: 10.1007/s12576-017-0521-4.
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There are 51 citations in total.

Details

Primary Language Turkish
Journal Section Makaleler
Authors

Gizem Yatkın 0000-0001-9706-3574

Seda Kuşoğlu Gültekin 0000-0003-0674-1582

İrem Gülfem Albayrak 0000-0003-3218-7060

Belkis Atasever Arslan

Publication Date December 31, 2022
Submission Date February 14, 2022
Published in Issue Year 2022 Volume: 5 Issue: 2

Cite

APA Yatkın, G., Kuşoğlu Gültekin, S., Albayrak, İ. G., Atasever Arslan, B. (2022). Beyin Homeostazında Bakır, Demir, Çinko Elementlerinin Parkinson Hastalığı ile İlişkisi. Doğu Fen Bilimleri Dergisi, 5(2), 1-11. https://doi.org/10.57244/dfbd.1073262