Evaluation of factors affecting morbidity, mortality, and graft survival in kidney transplant patients

Abstract

Objective: The aim of this study is to examine and evaluate the clinical findings and affecting factors related to graft and patient survival in kidney transplant patients at Dicle University Hospital. Method: 72 patients who underwent kidney transplantation at Dicle University Medical Faculty Hospital between January 2012 and September 2019 were included in the study. Demographic characteristics of patients, transplantation types, clinical and laboratory findings, pre-transplant dialysis types, renal failure etiologies, post-transplant complications, average patient and graft survival times and patient characteristics at the time of diagnosis, laboratory values, and treatment modalities were investigated. Results: In this study, the data collected from 72 patients who had kidney transplantation and 68 donors was analysed. The mean age of the patients was 32,7±13,8 years. 31 of patients were female, 41 were male. 56 of the transplants were performed living donors and 12 from cadavers. 9 patients died. The mean of patient survival was 94±3,4 months. Graft loss occured in 15 patients. The mean of graft survival was 86±4,3 months. Acute rejection occured in 10 patients. Chronic allograft nephropathy occured in 19 patients. Chronic allograft nephropathy was found more frequently in patients with acute rejection (p=0.017). In addition, graft loss was more common in patients with chronic allograft nephropathy (p=0.002). The dialysis duration was less than 12 months, and the BMI of the recipient was below 30 had a positive effect on patient survival. Conclusion: Recipient obesity and long-term dialysis programs reduce patient survival. In addition, prevention of rejection has a positive effect on patient and graft survival.

Keywords

• Kidney Transplantation
• Acute Rejection
• Graft Survival

References

1. 1.Kidney Disease: Improving Global Outcomes(KDIGO) CKD Work Group. KDIGO 2012 ClinicalPractice Guideline for the Evaluation andManagement of Chronic Kidney Disease. Kidneyinter., Suppl. 2013; 3: 1–150.
2. 2.Süleymanlar G, Utaş C, Arinsoy T, et al. Apopulation-based survey of Chronic Renal DiseaseIn Turkey--the CREDIT study. Nephrol DialTransplant. 2011 Jun; 26: 1862–71.
3. 3.Anderson J and Glynn LG: Definition of chronickidney disease and measurement of kidney functionin original research papers: A review of theliterature. Nephrol Dial Transplant 2011; 26: 2793-8.
4. 4.Saygılı ES, Seyahi N, Durak H, et al. Greftsağkalımını etkileyenfaktörlerin transplantböbrekbiyopsileriyledeğerlendirilmesi. Dicle Med J(2018) 45: 237-44.