The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results

Abstract

The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results

Abstract

Objectives: In this study, the relationship of cord blood Neutrophil Gelatinase-Associated Lipocalin (NGAL) with neonatal diseases was investigated. Methods: NGAL levels were measured in the cord blood of 180 babies born between 2015 and 2016. Patients were classified according to maternal diseases, neonatal diseases and demographic characteristics. Obtained data were compared with cord blood NGAL levels. Results: In our study, the mean NGAL levels were 1283.99 ng/mL in boys and 1306.52 ng/mL in girls. Umbilical cord blood NGAL levels of infants diagnosed with intrauterine growth retardation (1913.4±2833.5 ng/mL) and prolonged premature rupture of membranes (2594.2±2037.1 ng/mL) were found to be statistically high (p<0.05). There was no statistically significant difference between NGAL levels in infants of mothers with gestational diabetes mellitus, acyanotic congenital heart diseases, meconium aspiration syndrome, infants of mothers with preeclampsia, Apgar scores and infants of mothers with oligohydramnios (p>0.05). Conclusions: Neutrophil Gelatinase-Associated Lipocalin, may be useful as a diagnostic biomarker in the evaluation of maternal and neonatal diseases. However, studies on larger patient populations are needed.

Keywords

• Neutrophil Gelatinase Associated Lipocalin
• umbilical cord blood
• newborn

References

1. 1.American Society of Nephrology American Societyof Nephrology Renal Research Report. J Am SocNephrol 2005; 16: 1886–93.
2. 2.Bellos, I., Fitrou, G., Daskalakis, G. et al. Neutrophilgelatinase-associated lipocalin as predictor of acutekidney injury in neonates with perinatal asphyxia: asystematic review and meta-analysis. Eur J Pediatr.2018; 177: 1425-34.
3. 3.De Mul A, Parvex P, Wilhelm-Bals A. Neutrophilgelatinase-associated lipocalin distribution inpreterm newborns without acute kidney injury asdefined by a reference method. J Matern FetalNeonatal Med. 2021; 17; 1-5.
4. 4.Parravicini E, Nemerofsky SL, Michelson KA, et al.Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants.Pediatr Res. 2010; 67: 636-40.