The effect of Lymphocyte Monocyte Ratio (LMR) on 30-day mortality of non-HCC post-transplant liver patients admitted to the intensive care unit

Abstract

Aim: Our study aims to investigate the effect of the LMR value on the 30-day mortality and intensive care hospitalization days of post-transplant liver patients without hepatocellular cancer(HCC) admitted to the intensive care unit(ICU). Methods: Our retrospective study included post-liver transplant patients in the ICU of Dokuz Eylul University Hospital between 2010 and 2020. We recorded patients' age, gender, aetiology of liver disease, donor type (living or deceased), duration of cold ischemia, scores, hospitalization days in the ICU, and 30-day mortality. LMR was calculated by dividing the patient's lymphocyte count by the monocyte count. Statistical analyses were performed using SPSS software version 24.0. Results: 128 (92 male, 36 female) patients were included in our study. Twenty-four patients died within 30 days. The mean LMR was 1.498±2.134, and no significant difference existed between those with and without 30-day mortality (p=0.995). LMR value was not a predictor of mortality and ICU hospitalization days in these patients. Conclusion: Our study revealed that LMR does not predict mortality or hospitalization days in post-liver transplant patients without HCC. The results of our study and previous studies suggest that LMR alteration is associated with an immune state produced by the tumour microenvironment. Our findings suggest that LMR may not be a valuable biomarker for predicting patient outcomes in post-liver transplant patients without HCC. However, this study provides a starting point for further investigation into the role of LMR in cancer diseases.

Keywords

• Critical Care Medicine
• Hematological changes
• Liver failure
• Viral hepatitis

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