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A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome
Abstract
Objective: Valentino syndrome is a rare clinical entity that mimics acute appendicitis due to the retroperitoneal spread of a duodenal ulcer perforation. We present a case diagnosed preoperatively and treated laparoscopically.
Methods: A 51-year-old man presented with acute abdominal pain radiating from the epigastrium to the right lower quadrant. Physical examination revealed upper-quadrant tenderness and rebound. Laboratory testing showed a mild elevation in C-reactive protein (4.1 mg/L).
Results: Contrast-enhanced CT demonstrated intramural gas in the gastric antrum, inflammatory stranding within the periduodenal fat planes, free air anterior to the left hepatic lobe, and a reactively thickened appendix. A preoperative diagnosis of “Valentino appendicitis” was made. Laparoscopy confirmed a prepyloric perforation, which was repaired using a Graham patch. Appendectomy was not performed.
Conclusion: Valentino syndrome can be recognized preoperatively through careful clinical and radiologic assessment.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration, Medical Education, Health Services and Systems (Other)
Journal Section
Case Report
Publication Date
December 12, 2025
Submission Date
August 12, 2025
Acceptance Date
October 23, 2025
Published in Issue
Year 2025 Volume: 52 Number: 4
APA
Genç, Ö., & Altundal, Y. E. (2025). A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome. Dicle Medical Journal, 52(4), 899-902. https://doi.org/10.5798/dicletip.1841283
AMA
1.Genç Ö, Altundal YE. A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome. Dicle Medical Journal. 2025;52(4):899-902. doi:10.5798/dicletip.1841283
Chicago
Genç, Özgür, and Yusuf Emre Altundal. 2025. “A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome”. Dicle Medical Journal 52 (4): 899-902. https://doi.org/10.5798/dicletip.1841283.
EndNote
Genç Ö, Altundal YE (December 1, 2025) A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome. Dicle Medical Journal 52 4 899–902.
IEEE
[1]Ö. Genç and Y. E. Altundal, “A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome”, Dicle Medical Journal, vol. 52, no. 4, pp. 899–902, Dec. 2025, doi: 10.5798/dicletip.1841283.
ISNAD
Genç, Özgür - Altundal, Yusuf Emre. “A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome”. Dicle Medical Journal 52/4 (December 1, 2025): 899-902. https://doi.org/10.5798/dicletip.1841283.
JAMA
1.Genç Ö, Altundal YE. A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome. Dicle Medical Journal. 2025;52:899–902.
MLA
Genç, Özgür, and Yusuf Emre Altundal. “A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome”. Dicle Medical Journal, vol. 52, no. 4, Dec. 2025, pp. 899-02, doi:10.5798/dicletip.1841283.
Vancouver
1.Özgür Genç, Yusuf Emre Altundal. A Rare Clinical Condition Mimicking Acute Appendicitis: Valentino Syndrome. Dicle Medical Journal. 2025 Dec. 1;52(4):899-902. doi:10.5798/dicletip.1841283