Nilotinib İlişkili Akut Pankreatit Olgusu

Abstract

Kronik Myeloid Lösemi (KML), tedavisinde tirozin kinaz inhibitörlerinin (TKI) kullanılmasıyla önemli bir başarı elde edilen myeloproliferatif bir neoplazmdır. İlk nesil TKI olan imatinibten sonra geliştirilen ikinci nesil ajanlardan biri olan nilotinib, KML hastalarında daha erken ve derin moleküler yanıtlar sağlayabilmektedir. Bununla birlikte nilotinib, nadir de olsa ciddi yan etkilere yol açabilir. Pankreas enzimlerinde asemptomatik yükseklik sık görülse de, nadiren akut pankreatit gelişebilir. Bu klinik tablo genellikle tedavinin erken dönemlerinde ortaya çıkarken, gecikmiş başlangıçlı akut pankreatit daha seyrek bildirilmektedir. Biz, nilotinib tedavisi altında uzun süredir tam moleküler yanıtla izlenen bir KML hastasında gelişen gecikmiş başlangıçlı akut pankreatit olgusunu sunmayı amaçladık.

Keywords

• Kronik myeloid lösemi
• Nilotinib
• Pankreatit

A Case of Nilotinib Associated Acute Pancreatitis

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm in which the introduction of tyrosine kinase inhibitors (TKIs) has significantly improved clinical outcomes. Nilotinib, a second generation TKI developed after imatinib, is known to induce earlier and deeper molecular responses in patients with CML. However, despite its favorable efficacy profile, nilotinib may occasionally lead to serious adverse effects. Asymptomatic elevations in pancreatic enzymes are commonly observed, whereas the occurrence of acute pancreatitis is rare. This clinical manifestation typically arises during the early phase of treatment, while delayed-onset pancreatitis has only rarely been described. We aimed to present a case of delayed-onset acute pancreatitis in a CML patient who had achieved and maintained a deep molecular response under longterm nilotinib therapy.

Keywords

• Chronic myeloid leukemia
• Nilotinib
• Pancreatitis.

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