Letter to Editor

Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report

Volume: 53 Number: 3 September 11, 2026
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Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report

Abstract

This article presents a case demonstrating that valproic acid, which is widely used in the treatment of bipolar disorder, can lead to hyperammonemic encephalopathy, a rare but potentially serious adverse effect.

Keywords

References

  1. 1.Koroglu E. Mood stabilizers. Clinical Psychiatry,3rd ed. Esenkal Publishing, 2020: 808-10.
  2. 2.Ahmad S. Psychopharmacology. In: Sarikaya BB,Bozkurt A, eds. Kaplan & Sadock's Pocket Handbookof Clinical Psychiatry, 7th ed. Ankara: Gunes MedicalBookstores, 2023: 671-6.
  3. 3. Baddour E, Tewksbury A, Stauner N. Valproic acid-induced hyperammonemia: incidence, clinicalsignificance, and treatment management. MentHealth Clin. 2018; 8: 73-7.
  4. 4.Carr RB, Shrewsbury K. Hyperammonemia due tovalproic acid in a psychiatric setting. Am JPsychiatry. 2007; 164: 1020-7.
  5. 5.Wong YJ, Fan J, Wan A, et al. Valproic acid-associated hyperammonemia: a systematic review. JClin Psychopharmacol. 2023; 43: 283-94.
  6. 6.Wadzinski J, Franks R, Roane D, et al. Valproate-associated hyperammonemic encephalopathy. J AmBoard Fam Med. 2007; 20: 499-502.
  7. 7.Segura-Bruna N, Rodriguez-Campello A, Puente V,et al. Valproate-induced hyperammonemicencephalopathy. Acta Neurol Scand. 2006; 114: 1-7.
  8. 8.Yoo JY, Yang HS. Valproate-inducedhyperammonemic encephalopathy: a case report.Brain Neurorehabil. 2013; 6: 86-9.

Details

Primary Language

English

Subjects

Health Care Administration, Medical Education, Health Services and Systems (Other)

Journal Section

Letter to Editor

Authors

Rıdvan Toprak * This is me
Türkiye

Rukiye Ay
Türkiye

Publication Date

September 11, 2026

Submission Date

February 12, 2026

Acceptance Date

June 18, 2026

Published in Issue

Year 2026 Volume: 53 Number: 3

DOI

https://doi.org/10.5798/dicletip.2037497

IZ

https://izlik.org/JA27UU28KH

Cite

RIS / Bibtex
APA
Toprak, R., & Ay, R. (2026). Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Medical Journal, 53(3), 757-759. https://doi.org/10.5798/dicletip.2037497
AMA
1.Toprak R, Ay R. Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Medical Journal. 2026;53(3):757-759. doi:10.5798/dicletip.2037497
Chicago
Toprak, Rıdvan, and Rukiye Ay. 2026. “Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report”. Dicle Medical Journal 53 (3): 757-59. https://doi.org/10.5798/dicletip.2037497.
EndNote
Toprak R, Ay R (September 1, 2026) Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Medical Journal 53 3 757–759.
IEEE
[1]R. Toprak and R. Ay, “Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report”, Dicle Medical Journal, vol. 53, no. 3, pp. 757–759, Sept. 2026, doi: 10.5798/dicletip.2037497.
ISNAD
Toprak, Rıdvan - Ay, Rukiye. “Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report”. Dicle Medical Journal 53/3 (September 1, 2026): 757-759. https://doi.org/10.5798/dicletip.2037497.
JAMA
1.Toprak R, Ay R. Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Medical Journal. 2026;53:757–759.
MLA
Toprak, Rıdvan, and Rukiye Ay. “Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report”. Dicle Medical Journal, vol. 53, no. 3, Sept. 2026, pp. 757-9, doi:10.5798/dicletip.2037497.
Vancouver
1.Rıdvan Toprak, Rukiye Ay. Valproic Acid–Induced Hyperammonemic Encephalopathy: A Case Report. Dicle Medical Journal. 2026 Sep. 1;53(3):757-9. doi:10.5798/dicletip.2037497