The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism

Muammer Bilici; İbrahim Öz; Sevil İlikhan; Müzeyyen Arslaner; Elif Kahraman; Beyza Kılavuz; Zeynep Özdamar; Şehmus Ertop

doi:10.5798/diclemedj.0921.2015.04.0610

The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism

Abstract

Objective: In the present study, we aimed to consider the relation between the manifestations of venous thromboembolism (VTE) and gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T.

Methods: One hundred and forty four patients with idiopathic VTE were enrolled in this study. The data of patients were obtained from the medical records in hospital information system. The patients were grouped according to the location of VTE. In all subjects FVL, prothrombin G20210A, and MTHFR C677T were analyzed by specific polymerase chain reactions and restriction enzymes. Univariate and multivariate analysis were used to evaluate the relation between the groups and the gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T.

Results: The mean age of patients was 41.16 ± 13.23 years and the male / female ratio was 1.18. Among the patients with VTE, 44 (30.6%) had only DVT, 41 (28.5%) had only PE, 26 (18.1%) had both DVT and PE, 23 (16%) had cerebral veins thrombosis (CVT) and 10 (6.9%) had abdominal vein thrombosis The prevalence was found to be 46.5% for FVL, 13.2% for prothrombin G20210A and 45.1% for MTHFR C677T gene mutation among patients. There was no statistically difference between the manifestations of VTE regarding the gene mutations (p>0,05).

Conclusion: The findings of this study suggest that gene mutations including factor V Leiden (FVL), prothrombin G20210A and MTHFR C677T are not sufficient to determine the location of VTE.

Key words: Venous thromboembolism; factor V Leiden; prothrombin G20210A; MTHFR C677T

Keywords

Venöz tromboembolizm, faktör V Leiden, protrombin G20210A, MTHFR C677T

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Muammer Bilici

İbrahim Öz This is me

Sevil İlikhan This is me

Müzeyyen Arslaner This is me

Elif Kahraman This is me

Beyza Kılavuz This is me

Zeynep Özdamar This is me

Şehmus Ertop This is me

Publication Date

January 8, 2016

Submission Date

January 8, 2016

Acceptance Date

-

Published in Issue

Year 2015 Volume: 42 Number: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.04.0610

IZ

https://izlik.org/JA74GP66ZZ

Cite

RIS / Bibtex

APA

Bilici, M., Öz, İ., İlikhan, S., Arslaner, M., Kahraman, E., Kılavuz, B., Özdamar, Z., & Ertop, Ş. (2016). The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism. Dicle Medical Journal, 42(4), 467-471. https://doi.org/10.5798/diclemedj.0921.2015.04.0610

AMA

1.Bilici M, Öz İ, İlikhan S, et al. The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism. Dicle Medical Journal. 2016;42(4):467-471. doi:10.5798/diclemedj.0921.2015.04.0610

Chicago

Bilici, Muammer, İbrahim Öz, Sevil İlikhan, et al. 2016. “The Predictive Value of Factor V Leiden, Prothrombin G20210A and MTHFR C677T Gene Mutations on the Location of Venous Thromboembolism”. Dicle Medical Journal 42 (4): 467-71. https://doi.org/10.5798/diclemedj.0921.2015.04.0610.

EndNote

Bilici M, Öz İ, İlikhan S, Arslaner M, Kahraman E, Kılavuz B, Özdamar Z, Ertop Ş (January 1, 2016) The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism. Dicle Medical Journal 42 4 467–471.

IEEE

[1]M. Bilici et al., “The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism”, Dicle Medical Journal, vol. 42, no. 4, pp. 467–471, Jan. 2016, doi: 10.5798/diclemedj.0921.2015.04.0610.

ISNAD

Bilici, Muammer - Öz, İbrahim - İlikhan, Sevil - Arslaner, Müzeyyen - Kahraman, Elif - Kılavuz, Beyza - Özdamar, Zeynep - Ertop, Şehmus. “The Predictive Value of Factor V Leiden, Prothrombin G20210A and MTHFR C677T Gene Mutations on the Location of Venous Thromboembolism”. Dicle Medical Journal 42/4 (January 1, 2016): 467-471. https://doi.org/10.5798/diclemedj.0921.2015.04.0610.

JAMA

1.Bilici M, Öz İ, İlikhan S, Arslaner M, Kahraman E, Kılavuz B, Özdamar Z, Ertop Ş. The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism. Dicle Medical Journal. 2016;42:467–471.

MLA

Bilici, Muammer, et al. “The Predictive Value of Factor V Leiden, Prothrombin G20210A and MTHFR C677T Gene Mutations on the Location of Venous Thromboembolism”. Dicle Medical Journal, vol. 42, no. 4, Jan. 2016, pp. 467-71, doi:10.5798/diclemedj.0921.2015.04.0610.

Vancouver

1.Muammer Bilici, İbrahim Öz, Sevil İlikhan, Müzeyyen Arslaner, Elif Kahraman, Beyza Kılavuz, Zeynep Özdamar, Şehmus Ertop. The predictive value of factor V Leiden, prothrombin G20210A and MTHFR C677T Gene mutations on the location of venous thromboembolism. Dicle Medical Journal. 2016 Jan. 1;42(4):467-71. doi:10.5798/diclemedj.0921.2015.04.0610

Cited By

Güneydoğu Anadolu Bölgesi’ndeki Tekrarlayan Abortus Olgularında Protrombin, MTHFR, FV Leiden ve PAI-1 Polimorfizmlerinin Retrospektif Olarak İncelenmesi

Dicle Tıp Dergisi

https://doi.org/10.5798/dicletip.457243