Psoriasis Hastalarında Biyolojik Tedavinin Sistemik İnflamatuvar Belirteçler ve Plateletcrit Üzerine Etkisi

Abstract

Amaç: Psoriasis keratinositlerin anormal proliferasyonu ve inflamatuvar hücre infiltrasyonu ile karakterize kronik inflamatuvar bir deri hastalığıdır. İnflamatuvar hücre ve sitokinler hastaların dokuları ile birlikte periferal kanda da tespit edilmektedir. Bugüne kadar psoriasis vulgariste pek çok inflamatuvar belirteç bildirilmiştir. Çalışmamızın amacı psoriasisli hastalarda biyolojik tedavi öncesi ve sonrası nötrofil/lenfosit oranı (NLO), lenfosit/monosit (LMO), platelet/lenfosit oranı (PLO), RDW/platelet (RPO) gibi sistemik inflamatuvar belirteçler ile plateletcrit (PCT)’ nin değişimini araştırmaktır.

Yöntemler: Biyolojik ajanlar ile tedavi edilmiş 42 psoriasis vulgaris hastası geriye dönük olarak değerlendirilmiştir. Hastaların demografik bilgileri, klinik verileri ve tam kan sayımı biyolojik tedavinin başlangıcından önce ve tedavi sonrası 3. ayda değerlendirilmiştir.

Bulgular: Sedimentasyon, C-reaktif protein (CRP), nötrofil, trombosit, PCT, RDW, NLO ve PLO değerleri tedavi sonrası tedavi öncesi döneme göre istatistiksel anlamlı olarak azalmıştır (p<0.05). Ek olarak MPV, PDW, LMR ve RPR sonuçları değerlendirilmiş tedavi öncesi ve sonrası arasında istatistiksel anlamlı bir fark bulunamamıştır (p>0.05).

Sonuç: NLO, PLO ve PCT psoriasis vulgaris hastalarının biyolojik ajan ile tedavi etkinliğinin değerlendirilmesinde bir belirteç olarak kullanılabilirler.

Keywords

• biy olojik tedavi,biyolojik belirteçler

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