Alopesi areata’da IL - 6 Promotör Polimorfizmi

Abstract

Amaç: Alopesi areata (AA), T- hücre aracılı otoimmün bir hastalıktır ve sitokinler bu hastalığın gelişiminde önemli rol oynamaktadırlar. Önceki çalışmalar AA’lı hastaların serumlarında proinflamatuar bir sitokin olan IL–6’nın serum seviyesinin kontrol grubuna göre anlamlı düzeyde yüksek olduğunu göstermiştir. IL–6 geninin promotör bölgesinde bulunan -174 G/C polimorfizmi IL–6’nın serum seviyesini etkilemektedir. Sunulan bu çalışmanın amacı IL–6 -174 G/C promotör polimorfizmi ile AA’nın ilişkisinin olup olmadığını değerlendirmekti.

Yöntemler: Bu çalışmaya 146 AA’lı hasta ve 133 sağlıklı birey dahil edildi. IL–6 geni -174 G/C polimorfizminin genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.

Bulgular: Hasta ve kontrol grupları arasında IL–6 geni -174 G/C promotör polimorfizminin genotip ve allel frekanslarının dağılımı istatistiksel olarak anlamlı bulunmadı (sırasıyla, p=0.749 ve p=0.228).

Sonuç: Bu çalışma, IL–6 -174G/C polimorfizminin AA için bir yatkınlık faktörü olmadığını göstermektedir.

Keywords

• Alopesi areata,IL – 6,Otoimmünite

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