Prevalence of BRAF Mutation in Papillary Thyroid Cancer

Shatha Dmour; Ala’a Al - Maaitah; Tunc Eren; Ozgur Ekinci; Orhan Alimoglu

doi:10.5798/diclemedj.0921.2015.01.0521

Prevalence of BRAF Mutation in Papillary Thyroid Cancer

Abstract

Objectives: Papillary thyroid cancer (PTC) is the most common endocrine malignancy and the most common genetic anomaly with PTC is the BRAF V600E mutation. This mutation is linked to many clinical and pathological features and may have a diagnostic and therapeutic role especially in the era of targeted therapy. The aim of this study is to review the prevalence of BRAF V600E mutation in PTC, its distribution according to the histological subtype and geographic area and its association with the age of patients, gender, subtype and recurrence of tumors.

Methods: The Pubmed database was searched to look for articles about BRAF mutation in PTC. Outcomes of interest included prevalence, age, gender, country, subtype and recurrence.

Results: The prevalence of BRAF V600E mutation in PTC was 47%, with noticeably higher prevalence in the eastern countries. The prevalence of BRAF V600E was also higher in the tall and classic subtypes and could be associated with worse prognosis and higher risk of recurrence.

Conclusions: The BRAF mutation, which is more prevalent in the eastern countries, is determined to be an important molecular marker for PTC.

Keywords

Papillary thyroid cancer,BRAF mutation

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Details

Primary Language

English

Subjects

-

Journal Section

Review

Authors

Shatha Dmour This is me

Ala’a Al - Maaitah This is me

Tunc Eren This is me

Ozgur Ekinci This is me

Orhan Alimoglu

Publication Date

December 25, 2016

Submission Date

January 11, 2017

Acceptance Date

November 29, 2016

Published in Issue

Year 2016 Volume: 43 Number: 4

DOI

https://doi.org/10.5798/diclemedj.0921.2015.01.0521

IZ

https://izlik.org/JA96YP63UD

Cite

RIS / Bibtex

APA

Dmour, S., Maaitah, A. A.-, Eren, T., Ekinci, O., & Alimoglu, O. (2016). Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal, 43(4), 569-575. https://doi.org/10.5798/diclemedj.0921.2015.01.0521

AMA

1.Dmour S, Maaitah AA, Eren T, Ekinci O, Alimoglu O. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal. 2016;43(4):569-575. doi:10.5798/diclemedj.0921.2015.01.0521

Chicago

Dmour, Shatha, Ala’a Al - Maaitah, Tunc Eren, Ozgur Ekinci, and Orhan Alimoglu. 2016. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal 43 (4): 569-75. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

EndNote

Dmour S, Maaitah AA-, Eren T, Ekinci O, Alimoglu O (December 1, 2016) Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal 43 4 569–575.

IEEE

[1]S. Dmour, A. A.- Maaitah, T. Eren, O. Ekinci, and O. Alimoglu, “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”, Dicle Medical Journal, vol. 43, no. 4, pp. 569–575, Dec. 2016, doi: 10.5798/diclemedj.0921.2015.01.0521.

ISNAD

Dmour, Shatha - Maaitah, Ala’a Al - - Eren, Tunc - Ekinci, Ozgur - Alimoglu, Orhan. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal 43/4 (December 1, 2016): 569-575. https://doi.org/10.5798/diclemedj.0921.2015.01.0521.

JAMA

1.Dmour S, Maaitah AA-, Eren T, Ekinci O, Alimoglu O. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal. 2016;43:569–575.

MLA

Dmour, Shatha, et al. “Prevalence of BRAF Mutation in Papillary Thyroid Cancer”. Dicle Medical Journal, vol. 43, no. 4, Dec. 2016, pp. 569-75, doi:10.5798/diclemedj.0921.2015.01.0521.

Vancouver

1.Shatha Dmour, Ala’a Al - Maaitah, Tunc Eren, Ozgur Ekinci, Orhan Alimoglu. Prevalence of BRAF Mutation in Papillary Thyroid Cancer. Dicle Medical Journal. 2016 Dec. 1;43(4):569-75. doi:10.5798/diclemedj.0921.2015.01.0521