Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Ali Kemal Erenler; Derya Yapar; Özlem Terzi

doi:10.5798/dicletip.319750

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Abstract

Objective: Sepsis and severe sepsis (sepsis accompanied by acute organ dysfunction) are leading causes of death
worldwide. In this study, our aim was to investigate utility of biomarkers commonly used in diagnosis of sepsis in
discriminating these two entities.
Methods: Two-hundred and three patients involved were divided into 2 subgroups as sepsis and severe sepsis
according to Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock:
2012. Then groups were compared according to clinical and laboratory (including C-reactive protein (CRP) and
procalcitonin (PCT) levels) characteristics.
Results: Of 203 patients included into the study, 124 (61.1%) were male and 79 (38.9%) were female. The most
common reason for sepsis was urinary tract infection (n=64, 31.5%), followed by catheter infection (n=16, 7.9%) and
pneumonia (n=14, 6.9%). Escherichia coli was the most common agent in both blood and urinary cultures. Majority of
the patients were treated with ceftriaxone (n=33, 16.3%), followed by meronem/dapson (n=25, 12.3%). In both
groups, CRP and PCT levels were high, even higher in severe sepsis group. However, any statistical significance could
not be determined between groups. Mortality rate in sepsis patients was 6.4%.
Conclusion: Plasma levels of both markers elevate in sepsis and severe sepsis. It was determined that CRP and PCT is
higher in severe sepsis than in sepsis. However, the difference is not statistically significant. Plasma levels of CRP and
PCT are not useful in differential diagnosis of sepsis and severe sepsis.

Keywords

C-reactive protein,procalcitonin,sepsis,severe sepsis

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Ali Kemal Erenler
Türkiye

Derya Yapar This is me
Türkiye

Özlem Terzi This is me
Türkiye

Publication Date

June 7, 2017

Submission Date

June 7, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 44 Number: 2

DOI

https://doi.org/10.5798/dicletip.319750

IZ

https://izlik.org/JA44BM57PD

Cite

RIS / Bibtex

APA

Erenler, A. K., Yapar, D., & Terzi, Ö. (2017). Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department. Dicle Medical Journal, 44(2), 175-182. https://doi.org/10.5798/dicletip.319750

AMA

1.Erenler AK, Yapar D, Terzi Ö. Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department. Dicle Medical Journal. 2017;44(2):175-182. doi:10.5798/dicletip.319750

Chicago

Erenler, Ali Kemal, Derya Yapar, and Özlem Terzi. 2017. “Comparison of Procalcitonin and C-Reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department”. Dicle Medical Journal 44 (2): 175-82. https://doi.org/10.5798/dicletip.319750.

EndNote

Erenler AK, Yapar D, Terzi Ö (June 1, 2017) Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department. Dicle Medical Journal 44 2 175–182.

IEEE

[1]A. K. Erenler, D. Yapar, and Ö. Terzi, “Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department”, Dicle Medical Journal, vol. 44, no. 2, pp. 175–182, June 2017, doi: 10.5798/dicletip.319750.

ISNAD

Erenler, Ali Kemal - Yapar, Derya - Terzi, Özlem. “Comparison of Procalcitonin and C-Reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department”. Dicle Medical Journal 44/2 (June 1, 2017): 175-182. https://doi.org/10.5798/dicletip.319750.

JAMA

1.Erenler AK, Yapar D, Terzi Ö. Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department. Dicle Medical Journal. 2017;44:175–182.

MLA

Erenler, Ali Kemal, et al. “Comparison of Procalcitonin and C-Reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department”. Dicle Medical Journal, vol. 44, no. 2, June 2017, pp. 175-82, doi:10.5798/dicletip.319750.

Vancouver

1.Ali Kemal Erenler, Derya Yapar, Özlem Terzi. Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department. Dicle Medical Journal. 2017 Jun. 1;44(2):175-82. doi:10.5798/dicletip.319750

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Abstract

Keywords

References

Details

Primary Language

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Journal Section

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Publication Date

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Published in Issue

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