INH Direnç Mekanizmaları

Tanseli Gönlügür; Ugur Gönlügür

doi:10.5798/dicletip.339020

INH Direnç Mekanizmaları

Abstract

Her ne kadar izoniazid (INH) ‘ın Mycobacterium tuberculosis üzerindeki etki mekanizması tam anlaşılamamış olsa da öncü ilaç olan INH sitoplazmaya pasif difüzyon ile girmektedir. KatG geni tarafından kodlanan katalaz/peroksidaz enzimi ile aktiflenmektedir. INH ‘ın aktiflenmesi ile serbest metabolik radikaller oluşmakta, bunlar da mikolik asit sentezi gibi pek çok hücresel fonksiyonu bozmaktadırlar. KatG mutasyonları INH direncinin ana sebebidir. INH 'a dirençli klinik izolatların % 50 'den fazlasında katG 315. pozisyonda serin yerine treonin 'in değiştiği bir mutasyon vardır. İnhA, ndh ve pompa genleri gibi genler de INH direncine katkıda bulunabilirler. Bu derleme yazısı Mycobacterium tuberculosis 'de INH etki mekanizmasını ve ilaç direncinin moleküler temellerini özetlemektedir.

Keywords

İzoniazid,direnç,mekanizma,tüberküloz

References

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Details

Primary Language

English

Subjects

-

Journal Section

Review

Authors

Tanseli Gönlügür This is me
0000-0003-0751-6184
Türkiye

Ugur Gönlügür
0000-0001-8720-2788
Türkiye

Publication Date

September 20, 2017

Submission Date

September 20, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 44 Number: 3

DOI

https://doi.org/10.5798/dicletip.339020

IZ

https://izlik.org/JA82HA22GC

Cite

RIS / Bibtex

APA

Gönlügür, T., & Gönlügür, U. (2017). INH Direnç Mekanizmaları. Dicle Medical Journal, 44(3), 287-292. https://doi.org/10.5798/dicletip.339020

AMA

1.Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. Dicle Medical Journal. 2017;44(3):287-292. doi:10.5798/dicletip.339020

Chicago

Gönlügür, Tanseli, and Ugur Gönlügür. 2017. “INH Direnç Mekanizmaları”. Dicle Medical Journal 44 (3): 287-92. https://doi.org/10.5798/dicletip.339020.

EndNote

Gönlügür T, Gönlügür U (September 1, 2017) INH Direnç Mekanizmaları. Dicle Medical Journal 44 3 287–292.

IEEE

[1]T. Gönlügür and U. Gönlügür, “INH Direnç Mekanizmaları”, Dicle Medical Journal, vol. 44, no. 3, pp. 287–292, Sept. 2017, doi: 10.5798/dicletip.339020.

ISNAD

Gönlügür, Tanseli - Gönlügür, Ugur. “INH Direnç Mekanizmaları”. Dicle Medical Journal 44/3 (September 1, 2017): 287-292. https://doi.org/10.5798/dicletip.339020.

JAMA

1.Gönlügür T, Gönlügür U. INH Direnç Mekanizmaları. Dicle Medical Journal. 2017;44:287–292.

MLA

Gönlügür, Tanseli, and Ugur Gönlügür. “INH Direnç Mekanizmaları”. Dicle Medical Journal, vol. 44, no. 3, Sept. 2017, pp. 287-92, doi:10.5798/dicletip.339020.

Vancouver

1.Tanseli Gönlügür, Ugur Gönlügür. INH Direnç Mekanizmaları. Dicle Medical Journal. 2017 Sep. 1;44(3):287-92. doi:10.5798/dicletip.339020