A newborn with moderate hemophilia A with severe intracranial and extracranial hemorrhage: A case report
Abstract
Intracranial hemorrhage among term newborns is a rare clinical condition with high morbidity and mortality. Although major bleeding is relatively uncommon, the incidence of intracranial hemorrhage in hemophilic children is higher during the first few days of life than at any other stage in childhood, which relates to the trauma of delive ry.
Here, we reported a newborn case diagnosed with moderate hemophilia A, without the presence of a positive family
history of hemophilia and presenting with intracranial and extracranial hemorrhage and we aimed to emphasize that the early diagnosis and replacement therapy carries an essential importance.
Keywords
References
- 1. Lawn RM. The molecular genetics of hemophilia: blood clotting factors VIII and IX. Cell. 1985; 42:405-6.
- 2. Levene MI, Fawer CL, Lamont RF. Risk factors in the development of intraventricular haemorrhage in the preterm neonate. Arch Dis Child. 1982 ;57:410-7.
- 3. Eyster ME, Gill FM, Blatt PM, et al. Central nervous system bleeding in hemophiliacs. Blood. 1978; 51: 1179-88.
- 4. Kulkarni R, Lusher JM. Intracranial and extracranial hemorrhages in newborns with hemophilia: a review of the literature. J Pediatr Hematol Oncol.1999;21:289-95.
- 5. Green PM, Montandon AJ, Bentley DR, Giannelli F. Genetics and molecular biology of haemophilias A and B. Blood Coagul Fibrinolysis.1991;2:539-65.
- 6. Byams VR, Kouides PA, Kulkarni R, et al. Surveillance of female patients with inherited bleeding disorders in United States Haemophilia Treatment Centres. Haemophilia. 2011;17:6-13.
- 7. Walker I, Pai M, Akabutu J, et al. The Canadian Hemophilia Registry as the basis for a national system for monitoring the use of factor concentrates. Transfusion. 1995; 35:548-51.
- 8. Geraghty S, Dunkley T, Harrington C, et al. Practice patterns in haemophilia A therapy -global progress towards optimal care. Haemophilia. 2006; 12:75-81.
Details
Primary Language
English
Subjects
-
Journal Section
Case Report
Authors
Şebnem Kader
This is me
0000-0001-7585-4228
Türkiye
Pınar Gökçe Reis
This is me
0000-0001-9684-3595
Türkiye
Mehmet Mutlu
This is me
0000-0003-3666-3159
Türkiye
Yakup Aslan
This is me
0000-0001-9668-9559
Türkiye
Erol Erduran
This is me
Türkiye
Uğur Yazar
This is me
Türkiye
Publication Date
September 20, 2017
Submission Date
September 20, 2017
Acceptance Date
-
Published in Issue
Year 2017 Volume: 44 Number: 3
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Diagnostic radiology and radiotherapy
https://doi.org/10.22328/2079-5343-2018-9-3-23-27