p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Murat Yavuz; Pelin Köse Yaman; Nurdan Öztürk; Suna Timur; Elif Subaşı

doi:10.5798/dicletip.362482

p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity

Abstract

Objective: Thiosemicarbazone (TSC) containing three new mononuclear ruthenium(II)-arene complexes were synthesized so as to contribute to the development of ruthenium complexes with pharmacologically attracted properties.
Methods: Reactions of the ruthenium(II)-arene dimer [{RuCl(μ-Cl)(η6-p-cymene)}2] (1) with the respective TSC1-3 (1:2 molar ratio) in methanol resulted in p-cymene containing new conformationally rigid half-sandwich organometallic ruthenium(II)-arene complexes; [(η6-p-cymene)Ru(TSC1-κ3O,N,S)]Cl (I), [(η6-p-cymene)Ru(Cl)(TSC2-κ2N,S)]Cl (II), and [(η6-p-cymene)Ru(Cl)(TSC3-κ2N,S)]Cl (III). The molecular structures of complexes I, II and III were elucidated on the spectroscopic data obtained by the application of 1H NMR, Fourier transform infrared (FT-IR), UV-vis and elemental analysis techniques. In vitro antimicrobial activities of the synthesized three ruthenium(II)-arene complexes were evaluated using the disc diffusion method.
Results: The spectroscopic data indicated that TSC1 was bounded to the metal as a tridentate ligand with its thione sulfur atom, phenolic oxygen atom and azomethine nitrogen atom in the complex I, while TSC2 and TSC3 were bounded to metal center as bidentate manner through their thione sulfur atom and imine nitrogen (C=N) atom in the complexes II and III, respectively. The obtained antimicrobial activity results showed that these complexes efficiently inhibit the growth of Gram-positive bacterial strains.
Conclusion: The TSC1-3 containing ruthenium(II)-arene complexes were successfully synthesized and their molecular structures were also determined by the spectroscopic methods. All ruthenium(II)-arene complexes showed higher antibacterial activities against Gram-positive bacterial strains than the Gram-negative ones.
Keywords:

Keywords

Half-sandwich Ru(II)-arene complexes,benzaldehyde thiosemicarbazone,p-cymene,antimicrobial activity

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Murat Yavuz ^*
0000-0003-3452-8551

Pelin Köse Yaman This is me
0000-0003-0376-2177

Nurdan Öztürk This is me
0000-0002-9026-6376

Suna Timur This is me
0000-0002-1981-7577

Elif Subaşı This is me
0000-0002-4235-9391

Publication Date

December 5, 2017

Submission Date

December 5, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 44 Number: 4

DOI

https://doi.org/10.5798/dicletip.362482

IZ

https://izlik.org/JA54CN53MF

Cite

RIS / Bibtex

APA

Yavuz, M., Yaman, P. K., Öztürk, N., Timur, S., & Subaşı, E. (2017). p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity. Dicle Medical Journal, 44(4), 381-394. https://doi.org/10.5798/dicletip.362482

AMA

1.Yavuz M, Yaman PK, Öztürk N, Timur S, Subaşı E. p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity. Dicle Medical Journal. 2017;44(4):381-394. doi:10.5798/dicletip.362482

Chicago

Yavuz, Murat, Pelin Köse Yaman, Nurdan Öztürk, Suna Timur, and Elif Subaşı. 2017. “P-Cymene Based Organometallic Ruthenium(II)-Arene Complexes With Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity”. Dicle Medical Journal 44 (4): 381-94. https://doi.org/10.5798/dicletip.362482.

EndNote

Yavuz M, Yaman PK, Öztürk N, Timur S, Subaşı E (December 1, 2017) p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity. Dicle Medical Journal 44 4 381–394.

IEEE

[1]M. Yavuz, P. K. Yaman, N. Öztürk, S. Timur, and E. Subaşı, “p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity”, Dicle Medical Journal, vol. 44, no. 4, pp. 381–394, Dec. 2017, doi: 10.5798/dicletip.362482.

ISNAD

Yavuz, Murat - Yaman, Pelin Köse - Öztürk, Nurdan - Timur, Suna - Subaşı, Elif. “P-Cymene Based Organometallic Ruthenium(II)-Arene Complexes With Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity”. Dicle Medical Journal 44/4 (December 1, 2017): 381-394. https://doi.org/10.5798/dicletip.362482.

JAMA

1.Yavuz M, Yaman PK, Öztürk N, Timur S, Subaşı E. p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity. Dicle Medical Journal. 2017;44:381–394.

MLA

Yavuz, Murat, et al. “P-Cymene Based Organometallic Ruthenium(II)-Arene Complexes With Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity”. Dicle Medical Journal, vol. 44, no. 4, Dec. 2017, pp. 381-94, doi:10.5798/dicletip.362482.

Vancouver

1.Murat Yavuz, Pelin Köse Yaman, Nurdan Öztürk, Suna Timur, Elif Subaşı. p-Cymene Based Organometallic Ruthenium(II)-Arene Complexes with Benzaldehyde Derived Thiosemicarbazones: Synthesis, Characterization and Antimicrobial Activity. Dicle Medical Journal. 2017 Dec. 1;44(4):381-94. doi:10.5798/dicletip.362482

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