Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması

Bülent Koca; Bekir Kuru

doi:10.5798/dicletip.497892

Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması

Abstract

Amaç: Amacımız aksiller lenf nodu pozitif meme kanserinde nonsentinel lenf nodu (NSLN) pozitifliğine etki eden faktörleri araştırmak ve hasta grubumuzda Memorial Sloan-Kettering Cancer Center (MSKCC) ve Stanford nomogramlarının etkinliğini karşılaştırmaktır.

Yöntemler: 01.01.2008 - 31.08.2011 tarihleri arasında Ondokuz Mayıs Üniversitesi Tıp Fakültesi Genel Cerrahi Kliniği’nde sentinel lenf nodu biyopsisi (SLNB) sonucunda sentinel lenf nodunda metastaz saptanan invaziv meme kanseri olan 112 hasta çalışmaya alındı. Karşılaştırılacak değişkenler SPSS 15.0 versiyonu programından yararlanılarak kaydedildi. Lojistik regresyon analizi ile NSLN pozitifliğine etki eden risk faktörleri araştırıldı. P< 0.05 anlamlılık düzeyi olarak kabul edildi. Her iki nomogram icin “Receiver Operating Characteristics (ROC)” eğrileri oluşturuldu ve eğriler altındaki alanlar(AUC) hesaplandı. AUC değeri 0.70 ve üzerinde hesaplanan yöntem etkin olarak kabul edildi.

Bulgular: Tek değişkenli analizde tümör boyutu, multifokalite, lenfovasküler invazyon varlığı, SLN’daki metastazın makrometastaz oluşu, SLN’da kapsül dışı invazyon varlığı ve metastatik SLN sayısının toplam SLN sayısına oranı anlamlı bulundu. Çok değişkenli analizde lenfovasküler invazyon, SLN’da kapsül dışı invazyon ve metastatik SLN sayısının toplam SLN sayısına oranı NSLN metastazı ile ilgili bağımsız prediktif faktörler olarak saptandı. MSKCC ve Stanford nomogramlarının ikisinin de hasta grubumuzda etkin olmakla birlikte MSKCC nomogramının daha etkin olduğu sonucuna vardık.

Sonuç: Nomogramlar aksillada NSLN’unda metastataz olasılığı hakkında yol gösterici yöntemlerdir. Ancak henüz aksiller lenf nodu diseksiyonunun (ALND) yerini alacak kapasitede değildirler. NSLN pozitifliğine etki eden yeni prediktif faktörlerin ortaya konulması ile etkinlikleri artırılabilir. Her klinik kendisine en uygun nomogramı belirlemeli ve kullanmalı veya kendi nomogramını oluşturmalıdır.

Keywords

Meme kanseri,Non-sentinel lenf nodu pozitifliği

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Research Article

Authors

Bülent Koca ^*
0000-0001-7614-122X
Türkiye

Bekir Kuru This is me
0000-0001-7774-6431
Türkiye

Publication Date

December 13, 2018

Submission Date

December 15, 2018

Acceptance Date

July 23, 2018

Published in Issue

Year 2018 Volume: 45 Number: 4

DOI

https://doi.org/10.5798/dicletip.497892

IZ

https://izlik.org/JA47UC89LW

Cite

RIS / Bibtex

APA

Koca, B., & Kuru, B. (2018). Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması. Dicle Medical Journal, 45(4), 397-406. https://doi.org/10.5798/dicletip.497892

AMA

1.Koca B, Kuru B. Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması. Dicle Medical Journal. 2018;45(4):397-406. doi:10.5798/dicletip.497892

Chicago

Koca, Bülent, and Bekir Kuru. 2018. “Axiller Lenf Nodu Pozitif Meme Kanserinde Non-Sentinel Lenf Nodu Pozitifliğine Etki Eden Faktörler Ve Nomogramların Etkinliğinin Karşılaştırılması”. Dicle Medical Journal 45 (4): 397-406. https://doi.org/10.5798/dicletip.497892.

EndNote

Koca B, Kuru B (December 1, 2018) Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması. Dicle Medical Journal 45 4 397–406.

IEEE

[1]B. Koca and B. Kuru, “Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması”, Dicle Medical Journal, vol. 45, no. 4, pp. 397–406, Dec. 2018, doi: 10.5798/dicletip.497892.

ISNAD

Koca, Bülent - Kuru, Bekir. “Axiller Lenf Nodu Pozitif Meme Kanserinde Non-Sentinel Lenf Nodu Pozitifliğine Etki Eden Faktörler Ve Nomogramların Etkinliğinin Karşılaştırılması”. Dicle Medical Journal 45/4 (December 1, 2018): 397-406. https://doi.org/10.5798/dicletip.497892.

JAMA

1.Koca B, Kuru B. Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması. Dicle Medical Journal. 2018;45:397–406.

MLA

Koca, Bülent, and Bekir Kuru. “Axiller Lenf Nodu Pozitif Meme Kanserinde Non-Sentinel Lenf Nodu Pozitifliğine Etki Eden Faktörler Ve Nomogramların Etkinliğinin Karşılaştırılması”. Dicle Medical Journal, vol. 45, no. 4, Dec. 2018, pp. 397-06, doi:10.5798/dicletip.497892.

Vancouver

1.Bülent Koca, Bekir Kuru. Axiller lenf nodu pozitif meme kanserinde non-sentinel lenf nodu pozitifliğine etki eden faktörler ve nomogramların etkinliğinin karşılaştırılması. Dicle Medical Journal. 2018 Dec. 1;45(4):397-406. doi:10.5798/dicletip.497892