Graves’ Hastalığına Sahip Olgularda Tiroid Maligniteleri

Abstract

Amaç: Graves’ hastalığı otoimmün bir tiroid hastalığıdır. Eş zamanlı primer tiroid maligniteleri ile Graves’ hastalığı birlikteliği, giderek artan bir sıklıkta bildirilmektedir. Çalışmanın amacı laboratuarımızda incelenen Graves’ hastalığına sahip olguların tiroidektomi materyallerinde tiroid malignitesi sıklığını araştırmaktır. Yöntemler: 2010-2016 yılları arasında Recep Tayyip Erdoğan Üniversitesi Eğitim ve Araştırma Hastanesi Patoloji Laboratuarı’na Graves’ hastalığı nedeni ile gönderilen kırk (40) adet tiroidektomi materyaline ait preparat örnekleri yeniden incelendi. Bulgular: Kırk adet tiroidektomi materyalinin 11 (%27,5) tanesinde malignite saptandı. Malignitelerin tümü papiller karsinomdu. Makroskopik ya da mikroskopik olarak nodüle sahip Graves hastalıklı olgularda malignite sıklığı, nodülü olmayan gruba göre daha yüksek bulundu (p<0.05). Sonuç: Literatür ile uyumlu olarak, bu çalışmada da, Graves’ hastalığında nodül varlığının malignite riskini artırdığı gösterilmiştir. Nodüle sahip Graves’ hastaları klinik, radyolojik ve patolojik olarak dikkatli araştırılmalıdır

Keywords

• Graves’ hastalığı, tiroid karsinomu, insidental

Thyroid Malignancies In Patients With Graves Disease

Abstract

Objective: Graves’ disease is an autoimmune thyroid disorder. Concurrent Graves’ disease with primary thyroid malignancies has been reported at an increasing frequen­cy. The aim of this study is to investigate the prevalence of primary thyroid malignancies among thyroidectomy specimens with Graves’ disease examined in our depart­ment. Methods: The slides of forty patients, which underwent thyroidectomy due to Graves’ disease, were reevaluated in between 2010 to 2016. Results: 11 of 40 thyroidectomy specimens (27.5%) had primary thyroid malignancy. All malignancies were papil­lary carcinoma. The prevalence of malignancy was sig­nificantly higher in cases of Graves’ disease with mac­roscopic or microscopic nodule than in Graves’ patients without nodule (p<0.05). Conclusion: This study also showed that the Graves’ disease with nodule had more risk of thyroid malignancy. The patients with concurrent Graves’ disease and thyroid nodule should be carefully examined clinically, radiologi­cal, and pathologically for thyroid cancer.

Keywords

• Graves’ disease, thyroid carcinoma, incidental

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