Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Sara Erol; Banu Aydın; Hasibe Gokce Cinar; Tamer Yoldas; Aysegul Zenciroglu

doi:10.5798/dicletip.534847

Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates

Abstract

Objective: Cardiac catheterization is one of the basic procedures applied in the diagnosis and treatment of cardiovascular diseases. Development of thrombosis is a serious complication of catheterization. In this study, the frequency and the factors affecting the development of arterial thrombosis were prospectively evaluated in neonates who were subjected to diagnostic or interventional cardiac catheterization.

Methods: Twenty newborns that received femoral artery catheterization within 6-month period were enrolled in this study. Blood samples were taken for complete blood count, prothrombin, activated partial thromboplastin time, INR ratio and mutations of factorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 before the procedure. 100 U/kg bolus of heparin was infused during catheterization. 28 U/kg/hour infusion of heparin was given to the patients with clinically suspected thrombosis during first few hours after catheterization. Doppler ultrasonography was performed in all patients within 6 hours after catheterization.

Results: The gestational age of patients ranged from 31 to 40 weeks (median 39). Mean birth weight was 2996 ± 589 (1880-4000 gr). Arterial thrombosis was detected in 10 patients by Doppler USG. On development of arterial thrombosis, patient age, gender, diagnosis, treatments, platelet count, hemoglobin, prothrombin and activated partial thromboplastin time values, FactorV Leiden, prothrombin 20210A, methylenetetrahydrofolate reductase C667T and A1298 mutations were found as not impacting (p>0.05). Those who were found to have thrombosis in Doppler ultrasonography had lower INR levels compared to others (p= 0.023).

Conclusions: The rate of femoral arterial thrombosis in newborns after catheterization detected by Doppler ultrasonography was 50% in this study. Our data suggest that early clinical assessment for the diagnosis of thrombosis may be misleading but Doppler ultrasonography may be helpful early detection. Further studies are needed to prediction appropriate drugs and/or doses for prevention of thrombosis after arterial catheterization in newborns.

Keywords

newborn,thrombosis

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sara Erol ^*
0000-0002-8758-7662

Banu Aydın This is me
0000-0002-8677-6090

Hasibe Gokce Cinar This is me
0000-0003-2687-1544

Tamer Yoldas This is me
0000-0002-5086-6625

Aysegul Zenciroglu This is me
0000-0002-3488-4962

Publication Date

March 3, 2019

Submission Date

October 5, 2018

Acceptance Date

January 29, 2019

Published in Issue

Year 2019 Volume: 46 Number: 1

DOI

https://doi.org/10.5798/dicletip.534847

IZ

https://izlik.org/JA49LL54TY

Cite

RIS / Bibtex

APA

Erol, S., Aydın, B., Cinar, H. G., Yoldas, T., & Zenciroglu, A. (2019). Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates. Dicle Medical Journal, 46(1), 109-118. https://doi.org/10.5798/dicletip.534847

AMA

1.Erol S, Aydın B, Cinar HG, Yoldas T, Zenciroglu A. Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates. Dicle Medical Journal. 2019;46(1):109-118. doi:10.5798/dicletip.534847

Chicago

Erol, Sara, Banu Aydın, Hasibe Gokce Cinar, Tamer Yoldas, and Aysegul Zenciroglu. 2019. “Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates”. Dicle Medical Journal 46 (1): 109-18. https://doi.org/10.5798/dicletip.534847.

EndNote

Erol S, Aydın B, Cinar HG, Yoldas T, Zenciroglu A (March 1, 2019) Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates. Dicle Medical Journal 46 1 109–118.

IEEE

[1]S. Erol, B. Aydın, H. G. Cinar, T. Yoldas, and A. Zenciroglu, “Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates”, Dicle Medical Journal, vol. 46, no. 1, pp. 109–118, Mar. 2019, doi: 10.5798/dicletip.534847.

ISNAD

Erol, Sara - Aydın, Banu - Cinar, Hasibe Gokce - Yoldas, Tamer - Zenciroglu, Aysegul. “Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates”. Dicle Medical Journal 46/1 (March 1, 2019): 109-118. https://doi.org/10.5798/dicletip.534847.

JAMA

1.Erol S, Aydın B, Cinar HG, Yoldas T, Zenciroglu A. Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates. Dicle Medical Journal. 2019;46:109–118.

MLA

Erol, Sara, et al. “Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates”. Dicle Medical Journal, vol. 46, no. 1, Mar. 2019, pp. 109-18, doi:10.5798/dicletip.534847.

Vancouver

1.Sara Erol, Banu Aydın, Hasibe Gokce Cinar, Tamer Yoldas, Aysegul Zenciroglu. Arterial Thrombosis Secondary to Cardiac Catheterization in Neonates. Dicle Medical Journal. 2019 Mar. 1;46(1):109-18. doi:10.5798/dicletip.534847