Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism

Fatma Çolakoğlu; Hasan Hüseyin Dönmez; Fatma Kılıç

doi:10.5798/dicletip.574829

Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism

Abstract

Objective: Pregnancy is a stress factor for thyroid functions. The most commonly observed thyroid disorder is hypothyroidism. The immune system is affected both by pregnancy and hypothyroidism. This disorder causes a decrease in humoral and cell-mediated immune responses. This study was aimed at the comparison of alpha-naphthyl acetate esterase- and acid phosphatase-positive T lymphocyte distribution between healthy and hypothyroid pregnant women.

Methods: Blood samples were taken from healthy and hypothyroid pregnant women between June-December 2016. The sampled subjects included 10 healthy non-pregnant women (HC), 10 healthy pregnant women (HP), and 30 hypothyroid pregnant women in different trimesters of pregnancy (HpPTRI, HpPTRII and HpPTRIII). From each of these groups, six smears were prepared and histologically stained for ANAE and AcP-ase activity and with May Grünwald-Giemsa.

Results: The lowest ANAE- and AcP-ase-positive T lymphocyte percentages were detected in Group HP, and these percentages were higher in the hypothyroid pregnant groups, compared to Group HC (P<0.05). Based on PBL counts, the lowest lymphocyte and highest neutrophil leukocyte rates were detected in the pregnant groups. Hypothyroid pregnant women were determined to have monocytic leukocyte rates lower than those of Group HC and Group HP (P<0.05).

Conclusions: In this study, it was concluded that significant alterations had occurred in the PBL and ANAE- and AcP-ase-positive T lymphocyte counts of Group HP and the hypothyroid pregnant groups. These findings provide important data about the immunity of hypothyroid pregnant women.

Keywords

ANAE,AcP-ase,Hypothyroidism,Lymphocyte

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Fatma Çolakoğlu ^*
0000-0003-0410-5523

Hasan Hüseyin Dönmez This is me
0000-0003-4664-8489

Fatma Kılıç This is me
0000-0002-9735-3552

Publication Date

June 11, 2019

Submission Date

December 14, 2018

Acceptance Date

May 3, 2019

Published in Issue

Year 2019 Volume: 46 Number: 2

DOI

https://doi.org/10.5798/dicletip.574829

IZ

https://izlik.org/JA37UZ42EH

Cite

RIS / Bibtex

APA

Çolakoğlu, F., Dönmez, H. H., & Kılıç, F. (2019). Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism. Dicle Medical Journal, 46(2), 307-313. https://doi.org/10.5798/dicletip.574829

AMA

1.Çolakoğlu F, Dönmez HH, Kılıç F. Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism. Dicle Medical Journal. 2019;46(2):307-313. doi:10.5798/dicletip.574829

Chicago

Çolakoğlu, Fatma, Hasan Hüseyin Dönmez, and Fatma Kılıç. 2019. “Determination of ANAE and AcP-Ase Positivity in the Peripheral Blood of Pregnant Women With Hypothyroidism”. Dicle Medical Journal 46 (2): 307-13. https://doi.org/10.5798/dicletip.574829.

EndNote

Çolakoğlu F, Dönmez HH, Kılıç F (June 1, 2019) Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism. Dicle Medical Journal 46 2 307–313.

IEEE

[1]F. Çolakoğlu, H. H. Dönmez, and F. Kılıç, “Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism”, Dicle Medical Journal, vol. 46, no. 2, pp. 307–313, June 2019, doi: 10.5798/dicletip.574829.

ISNAD

Çolakoğlu, Fatma - Dönmez, Hasan Hüseyin - Kılıç, Fatma. “Determination of ANAE and AcP-Ase Positivity in the Peripheral Blood of Pregnant Women With Hypothyroidism”. Dicle Medical Journal 46/2 (June 1, 2019): 307-313. https://doi.org/10.5798/dicletip.574829.

JAMA

1.Çolakoğlu F, Dönmez HH, Kılıç F. Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism. Dicle Medical Journal. 2019;46:307–313.

MLA

Çolakoğlu, Fatma, et al. “Determination of ANAE and AcP-Ase Positivity in the Peripheral Blood of Pregnant Women With Hypothyroidism”. Dicle Medical Journal, vol. 46, no. 2, June 2019, pp. 307-13, doi:10.5798/dicletip.574829.

Vancouver

1.Fatma Çolakoğlu, Hasan Hüseyin Dönmez, Fatma Kılıç. Determination of ANAE and AcP-ase Positivity in the Peripheral Blood of Pregnant Women with Hypothyroidism. Dicle Medical Journal. 2019 Jun. 1;46(2):307-13. doi:10.5798/dicletip.574829

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https://doi.org/10.52973/rcfcv-e361815